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Luis Barreiro

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Genetic Medicine
AddressChicago IL 60637
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    Collapse Overview 
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    Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
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    Collapse Biography 
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    Lusófona University, LisbonMaster03/2003Biotechnological Engineering
    University of Paris VII, ParisPhD03/2008Population Genetics
    University of Chicago, ChicagoPost-doc02/2011Functional Genomics

    Collapse Research 
    Collapse research activities and funding
    R01AI175554     (HE, XIN)Dec 11, 2023 - Oct 31, 2028
    NIH
    Genetic variation of N6-methyladenosine (m6A) RNA modification in immune cells and its contribution to human diseases
    Role: Co-Principal Investigator
    RC2DK133947     (JABRI, BANA)Sep 15, 2022 - Jul 31, 2027
    NIH
    Tissue destruction and healing in Celiac Disease
    Role: Co-Principal Investigator
    R01GM134376     (BARREIRO, LUIS BRUNO)Sep 1, 2019 - May 31, 2024
    NIH
    Characterizing the impact of Yersinia Pestis to the phenotypic evolution of the human immune system
    Role: Principal Investigator
    R01AG057235     (TUNG, JENNY)Sep 15, 2017 - May 31, 2022
    NIH
    Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
    Role: Co-Principal Investigator
    R01GM102562     (TUNG, JENNY)Sep 1, 2012 - Sep 14, 2017
    NIH
    Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Campbell CR, Manser M, Shiratori M, Williams K, Barreiro L, Clutton-Brock T, Tung J. A female-biased gene expression signature of dominance in cooperatively breeding meerkats. Mol Ecol. 2024 Jul 17; e17467. PMID: 39021304.
      Citations:    
    2. Knight HR, Ketter E, Ung T, Weiss A, Ajit J, Chen Q, Shen J, Ip KM, Chiang CY, Barreiro L, Esser-Kahn A. High-throughput screen identifies non inflammatory small molecule inducers of trained immunity. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2400413121. PMID: 38976741.
      Citations:    Fields:    Translation:Animals
    3. Brunet-Ratnasingham E, Morin S, Randolph HE, Labrecque M, Bélair J, Lima-Barbosa R, Pagliuzza A, Marchitto L, Hultström M, Niessl J, Cloutier R, Sreng Flores AM, Brassard N, Benlarbi M, Prévost J, Ding S, Anand SP, Sannier G, Marks A, Wågsäter D, Bareke E, Zeberg H, Lipcsey M, Frithiof R, Larsson A, Zhou S, Nakanishi T, Morrison D, Vezina D, Bourassa C, Gendron-Lepage G, Medjahed H, Point F, Richard J, Larochelle C, Prat A, Cunningham JL, Arbour N, Durand M, Richards JB, Moon K, Chomont N, Finzi A, Tétreault M, Barreiro L, Wolf G, Kaufmann DE. Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity. Nat Commun. 2024 May 16; 15(1):4177. PMID: 38755196.
      Citations:    Fields:    Translation:HumansCells
    4. Maure A, Lawarée E, Fiorentino F, Pawlik A, Gona S, Giraud-Gatineau A, Eldridge MJG, Danckaert A, Hardy D, Frigui W, Keck C, Gutierrez C, Neyrolles O, Aulner N, Mai A, Hamon M, Barreiro LB, Brodin P, Brosch R, Rotili D, Tailleux L. A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection. PLoS Biol. 2024 Apr; 22(4):e3002259. PMID: 38683873; PMCID: PMC11081512.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Randolph HE, Aracena KA, Lin YL, Mu Z, Barreiro LB. Shaping immunity: The influence of natural selection on population immune diversity. Immunol Rev. 2024 May; 323(1):227-240. PMID: 38577999.
      Citations:    Fields:    Translation:HumansAnimals
    6. Bulut O, Kilic G, Debisarun PA, Röring RJ, Sun S, Kolkman M, van Rijssen E, Ten Oever J, Koenen H, Barreiro L, Domínguez-Andrés J, Netea MG. Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination. Immunol Lett. 2024 Jun; 267:106851. PMID: 38479480.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    7. Lougheed DR, Liu H, Aracena KA, Grégoire R, Pacis A, Pastinen T, Barreiro LB, Joly Y, Bujold D, Bourque G. EpiVar Browser: advanced exploration of epigenomics data under controlled access. Bioinformatics. 2024 Mar 04; 40(3). PMID: 38449289; PMCID: PMC10963074.
      Citations:    Fields:    Translation:HumansCells
    8. Aracena KA, Lin YL, Luo K, Pacis A, Gona S, Mu Z, Yotova V, Sindeaux R, Pramatarova A, Simon MM, Chen X, Groza C, Lougheed D, Gregoire R, Brownlee D, Boye C, Pique-Regi R, Li Y, He X, Bujold D, Pastinen T, Bourque G, Barreiro LB. Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Nat Genet. 2024 Mar; 56(3):408-419. PMID: 38424460.
      Citations: 4     Fields:    Translation:Humans
    9. Johnston RA, Aracena KA, Barreiro LB, Lea AJ, Tung J. DNA methylation-environment interactions in the human genome. Elife. 2024 Feb 26; 12. PMID: 38407202; PMCID: PMC10942648.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    10. Sarkar A, McInroy CJA, Harty S, Raulo A, Ibata NGO, Valles-Colomer M, Johnson KV, Brito IL, Henrich J, Archie EA, Barreiro LB, Gazzaniga FS, Finlay BB, Koonin EV, Carmody RN, Moeller AH. Microbial transmission in the social microbiome and host health and disease. Cell. 2024 01 04; 187(1):17-43. PMID: 38181740; PMCID: PMC10958648.
      Citations: 4     Fields:    Translation:HumansAnimals
    11. Barreiro LB. The evolutionary tale of lactase persistence in humans. Nat Rev Genet. 2024 Jan; 25(1):7. PMID: 37749209.
      Citations:    Fields:    Translation:Humans
    12. Song AT, Sindeaux RHM, Li Y, Affia H, Agnihotri T, Leclerc S, van Vliet PP, Colas M, Guimond JV, Patey N, Feulner L, Joyal JS, Haddad E, Barreiro L, Andelfinger G. Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue. Cell Rep. 2024 01 23; 43(1):113616. PMID: 38150367.
      Citations:    Fields:    Translation:HumansCells
    13. Johnston RA, Aracena KA, Barreiro LB, Lea AJ, Tung J. DNA methylation-environment interactions in the human genome. bioRxiv. 2023 Dec 15. PMID: 37293015; PMCID: PMC10245841.
      Citations:    
    14. Gregory DJ, Han F, Li P, Gritsenko M, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HS. Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species. medRxiv. 2023 Nov 30. PMID: 38076828; PMCID: PMC10705660.
      Citations:    
    15. Sun SJ, Aguirre-Gamboa R, de Bree LCJ, Sanz J, Dumaine A, Joosten LAB, Divangahi M, Netea MG, Barreiro LB. BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow. bioRxiv. 2023 Nov 28. PMID: 38077046; PMCID: PMC10705418.
      Citations:    
    16. Bobba S, Howard NC, Das S, Ahmed M, Khan N, Marchante I, Barreiro LB, Sanz J, Divangahi M, Khader SA. Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells. Infect Immun. 2023 10 17; 91(10):e0020123. PMID: 37754680; PMCID: PMC10580947.
      Citations:    Fields:    Translation:HumansCells
    17. Lougheed DR, Liu H, Aracena KA, Grégoire R, Pacis A, Pastinen T, Barreiro LB, Joly Y, Bujold D, Bourque G. EpiVar Browser: advanced exploration of epigenomics data under controlled access. bioRxiv. 2023 Aug 05. PMID: 37577719; PMCID: PMC10418203.
      Citations:    
    18. Shaw DG, Aguirre-Gamboa R, Vieira MC, Gona S, DiNardi N, Wang A, Dumaine A, Gelderloos-Arends J, Earley ZM, Meckel KR, Ciszewski C, Castillo A, Monroe K, Torres J, Shah SC, Colombel JF, Itzkowitz S, Newberry R, Cohen RD, Rubin DT, Quince C, Cobey S, Jonkers IH, Weber CR, Pekow J, Wilson PC, Barreiro LB, Jabri B. Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis. Nat Med. 2023 Jun; 29(6):1520-1529. PMID: 37322120; PMCID: PMC10287559.
      Citations: 3     Fields:    Translation:Humans
    19. Roche KE, Gesquiere LR, Barreiro LB, Alberts SC, Tung J, Mukherjee S, Archie EA, Bjork JR, Dasari MR, Grieneisen L, Jansen D, Gould TJ, Blekhman R, Gilbert JA. Universal gut microbial relationships in the gut microbiome of wild baboons. Elife. 2023 05 09; 12. PMID: 37158607; PMCID: PMC10292843.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    20. Demeure CE, Poinar H, Barreiro L, Pizarro-Cerdá J. [The Black Death, natural selection and susceptibility to auto-immune disorders]. Med Sci (Paris). 2023 04; 39(4):331-333. PMID: 37094265.
      Citations:    Fields:    Translation:Humans
    21. Groza C, Chen X, Pacis A, Simon MM, Pramatarova A, Aracena KA, Pastinen T, Barreiro LB, Bourque G. Genome graphs detect human polymorphisms in active epigenomic state during influenza infection. Cell Genom. 2023 May 10; 3(5):100294. PMID: 37228750; PMCID: PMC10203048.
      Citations: 1     Fields:    
    22. Chen X, Pacis A, Aracena KA, Gona S, Kwan T, Groza C, Lin YL, Sindeaux R, Yotova V, Pramatarova A, Simon MM, Pastinen T, Barreiro LB, Bourque G. Transposable elements are associated with the variable response to influenza infection. Cell Genom. 2023 May 10; 3(5):100292. PMID: 37228757; PMCID: PMC10203045.
      Citations: 3     Fields:    
    23. Vilgalys TP, Klunk J, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LB. Reply to Barton et al: signatures of natural selection during the Black Death. bioRxiv. 2023 Apr 07. PMID: 37066254; PMCID: PMC10104142.
      Citations:    
    24. Sun S, Barreiro LB, Aguirre-Gamboa R. Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity. Front Immunol. 2023; 14:1129577. PMID: 36999024; PMCID: PMC10043173.
      Citations: 2     Fields:    
    25. Mendonca LE, Pernet E, Khan N, Sanz J, Kaufmann E, Downey J, Grant A, Orlova M, Schurr E, Krawczyk C, Jones RG, Barreiro LB, Divangahi M. Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Front Immunol. 2022; 13:1044592. PMID: 36776396; PMCID: PMC9910175.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    26. Earley ZM, Lisicka W, Sifakis JJ, Kowalczyk A, Barlow JT, Shaw DG, Discepolo V, Tan IL, Gona S, Ernest JD, Matzinger P, Barreiro LB, Morgun A, Bendelac A, Ismagilov RF, Shulzhenko N, Riesenfeld SJ, Jabri B, Aguirre-Gamboa R. GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 01 10; 56(1):43-57.e10. PMID: 36630917; PMCID: PMC10262782.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    27. Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi M. Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Nature. 2023 02; 614(7948):530-538. PMID: 36599368; PMCID: PMC9945843.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Klunk J, Vilgalys TP, Demeure CE, Cheng X, Shiratori M, Madej J, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Eaton K, Golding GB, Devault A, Rouillard JM, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Poinar HN, Barreiro LB, Beau R, Varlik N, Grenier JC, Yotova V, Sindeaux R, Rouleau GA, Steinrücken M, Pizarro-Cerdá J. Evolution of immune genes is associated with the Black Death. Nature. 2022 Nov; 611(7935):312-319. PMID: 36261521; PMCID: PMC9580435.
      Citations: 43     Fields:    Translation:HumansCells
    29. Labrosse R, Boufaied I, Gona S, Randolph HE, Logan BR, Bourbonnais S, Chan W, Buckley RH, Parrott RE, Cuvelier GDE, Kapoor N, Chandra S, Eissa H, Goldman FD, Heimall J, O'Reilly R, Chaudhury S, Kolb EA, Shenoy S, Griffith LM, Pulsipher M, Kohn DB, Notarangelo LD, Pai SY, Cowan MJ, Dvorak CC, Puck JM, Barreiro LB, Bourdin B, Berthe C, Dávila Saldaña BJ, Haddad É, Decaluwe H. Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation. J Allergy Clin Immunol. 2023 01; 151(1):260-271. PMID: 35987350; PMCID: PMC9924130.
      Citations:    Fields:    Translation:HumansCells
    30. Downey J, Randolph HE, Pernet E, Tran KA, Khader SA, King IL, Barreiro LB, Divangahi M. Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus. Cell Rep. 2022 06 21; 39(12):110974. PMID: 35732121.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    31. Dasari MR, Roche K, Grieneisen L, Gould TJ, Gottel N, Jansen D, Gesquiere LR, Gordon JB, Learn NH, Wango TL, Mututua RS, Kinyua Warutere J, Siodi L, Mukherjee S, Barreiro LB, Alberts SC, Gilbert JA, Tung J, Blekhman R, Archie EA, Björk JR, Grenier JC, Yotova V. Synchrony and idiosyncrasy in the gut microbiome of wild baboons. Nat Ecol Evol. 2022 07; 6(7):955-964. PMID: 35654895; PMCID: PMC9271586.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    32. Trigodet F, Lolans K, Fogarty E, Shaiber A, Morrison HG, Barreiro L, Jabri B, Eren AM. High molecular weight DNA extraction strategies for long-read sequencing of complex metagenomes. Mol Ecol Resour. 2022 Jul; 22(5):1786-1802. PMID: 35068060; PMCID: PMC9177515.
      Citations: 18     Fields:    Translation:Humans
    33. Kaufmann E, Landekic M, Downey J, Chronopoulos J, Teimouri Nezhad S, Tran K, Vinh DC, Barreiro LB, Divangahi M. Lack of evidence for intergenerational inheritance of immune resistance to infections. Nat Immunol. 2022 02; 23(2):203-207. PMID: 35058614.
      Citations: 10     Fields:    
    34. Simons ND, Michopoulos V, Wilson M, Barreiro LB, Tung J. Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques. Philos Trans R Soc Lond B Biol Sci. 2022 02 28; 377(1845):20210132. PMID: 35000435; PMCID: PMC8743879.
      Citations: 6     Fields:    Translation:Animals
    35. Rogers D, Wang H, van Beek JJP, Rademaker TJ, Artusa P, Schneider C, Shen C, Wong DC, Bhagrath A, Condotta SA, Richer MJ, Martins AJ, Tsang JS, Barreiro LB, Langlais D, Textor J, Mandl JN, Sood A, Lebel MÈ, François P, Melichar HJ. Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential. Cell Rep. 2021 11 30; 37(9):110064. PMID: 34852223.
      Citations: 11     Fields:    Translation:AnimalsCells
    36. Randolph HE, Fiege JK, Thielen BK, Mickelson CK, Shiratori M, Langlois RA, Barreiro LB, Barroso-Batista J. Genetic ancestry effects on the response to viral infection are pervasive but cell type specific. Science. 2021 Nov 26; 374(6571):1127-1133. PMID: 34822289; PMCID: PMC8957271.
      Citations: 36     Fields:    Translation:HumansCells
    37. Correa-Macedo W, Olivenstein R, Dumaine A, Kalsdorf B, Lange C, Barreiro LB, Schurr E, Fava VM, Orlova M, Cassart P, Sanz J, Xu YZ, Sindeaux RH, Yotova V, Pacis A, Girouard J, Routy JP. Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis. J Clin Invest. 2021 11 15; 131(22). PMID: 34473646; PMCID: PMC8592547.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    38. Findley AS, Zhang X, Boye C, Lin YL, Kalita CA, Barreiro L, Lohmueller KE, Pique-Regi R, Luca F. A signature of Neanderthal introgression on molecular mechanisms of environmental responses. PLoS Genet. 2021 09; 17(9):e1009493. PMID: 34570765; PMCID: PMC8509894.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Mayassi T, Barreiro LB, Rossjohn J, Jabri B. A multilayered immune system through the lens of unconventional T cells. Nature. 2021 07; 595(7868):501-510. PMID: 34290426; PMCID: PMC8514118.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    40. Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M, Artyomov MN, Kaushal D, Khader SA. Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control. mBio. 2021 08 31; 12(4):e0146821. PMID: 34253059; PMCID: PMC8406195.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Grieneisen L, Dasari M, Gould TJ, Jansen D, Gottel N, Gordon JB, Learn NH, Gesquiere LR, Wango TL, Mututua RS, Warutere JK, Siodi L, Gilbert JA, Alberts SC, Tung J, Archie EA, Blekhman R, Björk JR, Grenier JC, Yotova V, Barreiro LB. Gut microbiome heritability is nearly universal but environmentally contingent. Science. 2021 07 09; 373(6551):181-186. PMID: 34244407; PMCID: PMC8377764.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    42. Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG, Chavakis T, Matarese G. Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jul; 22(7):928. PMID: 34017127.
      Citations: 2     Fields:    
    43. Grenier JC, Kohn J, Johnson Z, Lanford RE, Brinkworth JF, Hawash MBF, Sanz-Remón J, Yotova V, Barreiro LB. Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity. Proc Natl Acad Sci U S A. 2021 03 30; 118(13). PMID: 33771921; PMCID: PMC8020666.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    44. Barreiro LB, Chervonsky A. My Old World chap, this a-gal is not for you. Cell Host Microbe. 2021 03 10; 29(3):315-317. PMID: 33705699.
      Citations:    Fields:    Translation:Animals
    45. Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG, Chavakis T, Matarese G. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 01; 22(1):2-6. PMID: 33293712; PMCID: PMC8020292.
      Citations: 175     Fields:    Translation:HumansAnimalsPHPublic Health
    46. Khan N, Downey J, Sanz J, Kaufmann E, Blankenhaus B, Pacis A, Pernet E, Ahmed E, Cardoso S, Nijnik A, Mazer B, Sassetti C, Behr MA, Soares MP, Barreiro LB, Divangahi M. M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity. Cell. 2020 10 29; 183(3):752-770.e22. PMID: 33125891; PMCID: PMC7599081.
      Citations: 88     Fields:    Translation:AnimalsCells
    47. Randolph HE, Barreiro LB. Herd Immunity: Understanding COVID-19. Immunity. 2020 05 19; 52(5):737-741. PMID: 32433946; PMCID: PMC7236739.
      Citations: 467     Fields:    Translation:HumansCellsPHPublic Health
    48. Kim SM, DeFazio JR, Hyoju SK, Sangani K, Keskey R, Krezalek MA, Khodarev NN, Sangwan N, Christley S, Harris KG, Malik A, Zaborin A, Bouziat R, Ranoa DR, Wiegerinck M, Ernest JD, Shakhsheer BA, Fleming ID, Weichselbaum RR, Antonopoulos DA, Gilbert JA, Barreiro LB, Zaborina O, Jabri B, Alverdy JC. Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. Nat Commun. 2020 05 11; 11(1):2354. PMID: 32393794; PMCID: PMC7214422.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    49. Barreiro LB, Quintana-Murci L. Evolutionary and population (epi)genetics of immunity to infection. Hum Genet. 2020 Jun; 139(6-7):723-732. PMID: 32285198; PMCID: PMC7285878.
      Citations: 14     Fields:    Translation:HumansAnimals
    50. Sun S, Barreiro LB. The epigenetically-encoded memory of the innate immune system. Curr Opin Immunol. 2020 08; 65:7-13. PMID: 32220702; PMCID: PMC7529637.
      Citations: 14     Fields:    Translation:HumansAnimals
    51. Netea MG, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E, Domínguez-Andrés J. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020 06; 20(6):375-388. PMID: 32132681; PMCID: PMC7186935.
      Citations: 830     Fields:    Translation:HumansAnimals
    52. Kim SM, Lejeune T, Palanski BA, Ernest JD, Tastet O, Voisine J, Discepolo V, Marietta EV, Hawash MBF, Ciszewski C, Bouziat R, Panigrahi K, Horwath I, Zurenski MA, Lawrence I, Dumaine A, Yotova V, Grenier JC, Murray JA, Khosla C, Barreiro LB, Jabri B, Abadie V. IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. 2020 02; 578(7796):600-604. PMID: 32051586; PMCID: PMC7047598.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    53. Bogdan L, Barreiro L, Bourque G. Transposable elements have contributed human regulatory regions that are activated upon bacterial infection. Philos Trans R Soc Lond B Biol Sci. 2020 03 30; 375(1795):20190332. PMID: 32075553; PMCID: PMC7061985.
      Citations: 9     Fields:    Translation:HumansCells
    54. Chakravarti N, Lee DA, Colamartino ABL, Lemieux W, Bifsha P, Nicoletti S, Sanz J, Roméro H, Selleri S, Béland K, Guiot M, Tremblay-Laganière C, Dicaire R, Barreiro L, Verhoeyen E, Haddad E. Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector. Front Immunol. 2019; 10:2873. PMID: 31921138; PMCID: PMC6927467.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    55. Maurizio PL, Snyder-Mackler N, Simons ND, Voyles T, Kohn J, Michopoulos V, Wilson M, Tung J, Barreiro LB, Sanz J. Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23317-23322. PMID: 31611381; PMCID: PMC7519294.
      Citations: 20     Fields:    Translation:Animals
    56. Ciszewski C, Discepolo V, Pacis A, Doerr N, Tastet O, Mayassi T, Basheer A, Al-Mawsawi LQ, Green PHR, Waldmann TA, Azimi N, Tagaya Y, Barreiro LB, Jabri B, Maglio M, Auricchio R, Troncone R. Identification of a ?c Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21. Gastroenterology. 2020 02; 158(3):625-637.e13. PMID: 31622625; PMCID: PMC7861144.
      Citations: 11     Fields:    Translation:HumansCells
    57. Choin J, Sikora M, Siddle K, Harmant C, Costa HA, Perry GH, Barreiro LB, Bustamante CD, Patin E, Lopez M, Silvert M, Mouguiama-Daouda P, Hombert JM, Froment A, Le Bomin S, Verdu P, Quintana-Murci L. Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest. Curr Biol. 2019 09 09; 29(17):2926-2935.e4. PMID: 31402299.
      Citations: 13     Fields:    Translation:HumansCells
    58. Harrison GF, Sanz J, Boulais J, Mina MJ, Grenier JC, Leng Y, Dumaine A, Yotova V, Bergey CM, Nsobya SL, Elledge SJ, Schurr E, Quintana-Murci L, Perry GH, Barreiro LB. Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists. Nat Ecol Evol. 2019 08; 3(8):1253-1264. PMID: 31358949; PMCID: PMC6684323.
      Citations: 18     Fields:    Translation:HumansCells
    59. Andrich DE, Melbouci L, Ou Y, Auclair N, Mercier J, Grenier JC, Lira FS, Barreiro LB, Danialou G, Comtois AS, Lavoie JC, St-Pierre DH. A Short-Term High-Fat Diet Alters Glutathione Levels and IL-6 Gene Expression in Oxidative Skeletal Muscles of Young Rats. Front Physiol. 2019; 10:372. PMID: 31024337; PMCID: PMC6468044.
      Citations: 12     
    60. Pacis A, Tailleux L, Randolph HE, Yotova V, Dumaine A, Grenier JC, Barreiro LB, Mailhot-Léonard F. Gene activation precedes DNA demethylation in response to infection in human dendritic cells. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6938-6943. PMID: 30886108; PMCID: PMC6452747.
      Citations: 66     Fields:    Translation:HumansCells
    61. Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell. 2019 02 21; 176(5):967-981.e19. PMID: 30739797; PMCID: PMC6667191.
      Citations: 69     Fields:    Translation:HumansCells
    62. Debray R, Snyder-Mackler N, Kohn JN, Wilson ME, Tung J, Barreiro LB. Social affiliation predicts mitochondrial DNA copy number in female rhesus macaques. Biol Lett. 2019 01 31; 15(1):20180643. PMID: 30958211; PMCID: PMC6371908.
      Citations: 3     Fields:    Translation:AnimalsCells
    63. Lea AJ, Vockley CM, Johnston RA, Del Carpio CA, Barreiro LB, Reddy TE, Tung J. Genome-wide quantification of the effects of DNA methylation on human gene regulation. Elife. 2018 12 21; 7. PMID: 30575519; PMCID: PMC6303109.
      Citations: 55     Fields:    Translation:HumansCells
    64. Snyder-Mackler N, Kohn JN, Voyles T, Pique-Regi R, Wilson ME, Barreiro LB, Tung J, Sanz J. Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1219-1228. PMID: 30538209; PMCID: PMC6347725.
      Citations: 40     Fields:    Translation:AnimalsCells
    65. Bergey CM, Lopez M, Patin E, Cohen JA, Perry GH, Harrison GF, Quintana-Murci L, Barreiro LB. Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11256-E11263. PMID: 30413626; PMCID: PMC6275523.
      Citations: 19     Fields:    Translation:Humans
    66. CoHEART Consortium, Piché J, Gosset N, Legault LM, Pacis A, Oneglia A, Caron M, Chetaille P, Barreiro L, Liu D, Qi X, Nattel S, Leclerc S, Breton-Larrivée M, McGraw S, Andelfinger G. Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-ß Signaling and Epigenomics. Cell Mol Gastroenterol Hepatol. 2019; 7(2):411-431. PMID: 30739867; PMCID: PMC6369230.
      Citations: 7     Fields:    Translation:HumansCells
    67. Sanz J, Randolph HE, Barreiro LB. Genetic and evolutionary determinants of human population variation in immune responses. Curr Opin Genet Dev. 2018 12; 53:28-35. PMID: 29960896.
      Citations: 11     Fields:    Translation:Humans
    68. Randolph HE, Barreiro LB. Holy Immune Tolerance, Batman! Immunity. 2018 06 19; 48(6):1074-1076. PMID: 29924972; PMCID: PMC7110998.
      Citations: 11     Fields:    Translation:HumansAnimals
    69. Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Godley LA, Barreiro LB, Jabri B, Buscarlet M, Busque L, Verdú EF. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584. PMID: 29769727; PMCID: PMC6238954.
      Citations: 185     Fields:    Translation:AnimalsCells
    70. Lopez M, Kousathanas A, Harmant C, Perry GH, Patin E, Quach H, Mouguiama-Daouda P, Hombert JM, Froment A, Barreiro LB, Verdu P, Quintana-Murci L. The demographic history and mutational load of African hunter-gatherers and farmers. Nat Ecol Evol. 2018 04; 2(4):721-730. PMID: 29531345.
      Citations: 19     Fields:    Translation:Humans
    71. Kaufmann E, Dunn JL, Khan N, Tzelepis F, Pernet E, Dumaine A, Grenier JC, Ahmed E, Belle J, Besla R, Mazer B, King IL, Nijnik A, Robbins CS, Divangahi M, Sanz J, Mendonça LE, Pacis A, Mailhot-Léonard F, Barreiro LB. BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell. 2018 01 11; 172(1-2):176-190.e19. PMID: 29328912.
      Citations: 469     Fields:    Translation:AnimalsCells
    72. Tung J, Barreiro LB. The contribution of admixture to primate evolution. Curr Opin Genet Dev. 2017 Dec; 47:61-68. PMID: 28923540.
      Citations: 19     Fields:    Translation:HumansAnimals
    73. Cao M, Liu HL, Durosier LD, Frasch MG, Cortes M, Moore CS, Burns P, Fecteau G, Desrochers A, Barreiro LB, Antel JP. a7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis. Sci Rep. 2017 09 06; 7(1):10645. PMID: 28878260; PMCID: PMC5587535.
      Citations: 16     Fields:    Translation:AnimalsCells
    74. Kim-Hellmuth S, Bechheim M, Mohammadi P, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Barreiro LB, Pickrell JK, Lappalainen T, Schumacher J, Hornung V, Pütz B, Nédélec Y, Nöthen MM, Müller-Myhsok B. Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations. Nat Commun. 2017 08 16; 8(1):266. PMID: 28814792; PMCID: PMC5559603.
      Citations: 84     Fields:    Translation:HumansCells
    75. Fava VM, Orlova M, Thuc NV, Thai VH, Laval G, Barreiro LB, Schurr E, Manry J, Nédélec Y, Cobat A. Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation. PLoS Genet. 2017 Aug; 13(8):e1006952. PMID: 28793313; PMCID: PMC5565194.
      Citations: 21     Fields:    Translation:HumansCells
    76. Blischak JD, Tailleux L, Myrthil M, Morizot G, Platen CV, Brosch R, Gilad Y, Charlois C, Bergot E, Dinh A, Chény O, Herrmann JL, Barreiro LB. Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells. Sci Rep. 2017 07 18; 7(1):5702. PMID: 28720766; PMCID: PMC5516010.
      Citations: 6     Fields:    Translation:HumansCells
    77. Patin E, Lopez M, Grollemund R, Harmant C, Laval G, Perry GH, Bustamante CD, Verdu P, Quach H, Barreiro LB, Froment A, Heyer E, Massougbodji A, Fortes-Lima C, Migot-Nabias F, Bellis G, Dugoujon JM, Pereira JB, Fernandes V, Pereira L, Van der Veen L, Mouguiama-Daouda P, Hombert JM, Quintana-Murci L. Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America. Science. 2017 05 05; 356(6337):543-546. PMID: 28473590.
      Citations: 101     Fields:    Translation:Humans
    78. Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B, Costes LM, Abadie V. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 04 07; 356(6333):44-50. PMID: 28386004; PMCID: PMC5506690.
      Citations: 183     Fields:    Translation:HumansAnimalsCells
    79. Sams AJ, Dumaine A, Yotova V, Alfieri C, Tanner JE, Messer PW, Barreiro LB, Nédélec Y. Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans. Genome Biol. 2016 11 29; 17(1):246. PMID: 27899133; PMCID: PMC5129249.
      Citations: 67     Fields:    Translation:HumansAnimals
    80. Snyder-Mackler N, Kohn JN, Morrow S, Shaver AO, Pique-Regi R, Johnson ZP, Wilson ME, Tung J, Sanz J, Brinkworth JF, Grenier JC, Barreiro LB. Social status alters immune regulation and response to infection in macaques. Science. 2016 11 25; 354(6315):1041-1045. PMID: 27885030; PMCID: PMC5498102.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    81. Cortes M, Cao M, Liu HL, Burns P, Moore C, Fecteau G, Desrochers A, Barreiro LB, Antel JP, Frasch MG. RNAseq profiling of primary microglia and astrocyte cultures in near-term ovine fetus: A glial in vivo-in vitro multi-hit paradigm in large mammalian brain. J Neurosci Methods. 2017 01 30; 276:23-32. PMID: 27856275; PMCID: PMC5359012.
      Citations: 6     Fields:    Translation:AnimalsCells
    82. Szpiech ZA, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Nédélec Y, Sanz J, Baharian G, Pacis A, Pagé Sabourin A, Barreiro LB. Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. Cell. 2016 Oct 20; 167(3):657-669.e21. PMID: 27768889.
      Citations: 250     Fields:    
    83. Pai AA, Brinkworth JF, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB, Baharian G, Pagé Sabourin A, Nédélec Y. Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection. PLoS Genet. 2016 Sep; 12(9):e1006338. PMID: 27690314; PMCID: PMC5045211.
      Citations: 51     Fields:    
    84. Kohn JN, Snyder-Mackler N, Barreiro LB, Johnson ZP, Tung J, Wilson ME. Dominance rank causally affects personality and glucocorticoid regulation in female rhesus macaques. Psychoneuroendocrinology. 2016 12; 74:179-188. PMID: 27639059; PMCID: PMC5494262.
      Citations: 16     Fields:    Translation:Animals
    85. Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JH. Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection. Nucleic Acids Res. 2016 12 15; 44(22):10571-10587. PMID: 27604870; PMCID: PMC5159539.
      Citations: 24     Fields:    Translation:HumansCells
    86. Richards AL, Burns MB, Alazizi A, Barreiro LB, Pique-Regi R, Blekhman R, Luca F. Genetic and transcriptional analysis of human host response to healthy gut microbiota. mSystems. 2016 Jul-Aug; 1(4). PMID: 27709125; PMCID: PMC5047527.
      Citations: 19     Fields:    
    87. Blekhman R, Tang K, Archie EA, Barreiro LB, Johnson ZP, Wilson ME, Kohn J, Yuan ML, Gesquiere L, Grieneisen LE, Tung J. Common methods for fecal sample storage in field studies yield consistent signatures of individual identity in microbiome sequencing data. Sci Rep. 2016 08 16; 6:31519. PMID: 27528013; PMCID: PMC4985740.
      Citations: 31     Fields:    Translation:Animals
    88. Langlais D, Barreiro LB, Gros P. The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med. 2016 Apr 04; 213(4):585-603. PMID: 27001747; PMCID: PMC4821649.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    89. Snyder-Mackler N, Kohn JN, Barreiro LB, Johnson ZP, Wilson ME, Tung J. Social status drives social relationships in groups of unrelated female rhesus macaques. Anim Behav. 2016 Jan 01; 111:307-317. PMID: 26769983; PMCID: PMC4707678.
      Citations: 20     Fields:    
    90. Fagny M, Patin E, MacIsaac JL, Rotival M, Jones MJ, Siddle KJ, Harmant C, McEwen LM, Perry GH, Kobor MS, Quintana-Murci L, Flutre T, Quach H, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Barreiro LB. The epigenomic landscape of African rainforest hunter-gatherers and farmers. Nat Commun. 2015 Nov 30; 6:10047. PMID: 26616214; PMCID: PMC4674682.
      Citations: 35     Fields:    Translation:HumansCells
    91. Blischak JD, Tailleux L, Mitrano A, Gilad Y, Barreiro LB. Mycobacterial infection induces a specific human innate immune response. Sci Rep. 2015 Nov 20; 5:16882. PMID: 26586179; PMCID: PMC4653619.
      Citations: 36     Fields:    Translation:HumansCells
    92. Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad Y. Genome-Wide Association Studies of the Human Gut Microbiota. PLoS One. 2015; 10(11):e0140301. PMID: 26528553; PMCID: PMC4631601.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    93. Pacis A, Tailleux L, Morin AM, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Kobor MS, Pique-Regi R, Gilad Y, Barreiro LB, Lambourne J, Pastinen T. Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. 2015 Dec; 25(12):1801-11. PMID: 26392366; PMCID: PMC4665002.
      Citations: 109     Fields:    Translation:HumansCells
    94. Gross JA, Chen GG, Ernst C, Turecki G, Pacis A, Barreiro LB. Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution. BMC Genomics. 2015 Sep 03; 16:672. PMID: 26334641; PMCID: PMC4559220.
      Citations: 21     Fields:    Translation:HumansCells
    95. Cao M, Cortes M, Moore CS, Leong SY, Durosier LD, Burns P, Fecteau G, Desrochers A, Auer RN, Barreiro LB, Antel JP, Frasch MG. Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation. Front Cell Neurosci. 2015; 9:294. PMID: 26300730; PMCID: PMC4524165.
      Citations: 24     
    96. Siddle KJ, Tailleux L, Loh YH, Gicquel B, Farinelli L, Deschamps M, Deluen C, Antoniewski C, Barreiro LB, Quintana-Murci L. bacterial infection drives the expression dynamics of microRNAs and their isomiRs. PLoS Genet. 2015 Mar; 11(3):e1005064. PMID: 25793259; PMCID: PMC4368565.
      Citations: 37     Fields:    Translation:HumansCells
    97. Tung J, Barreiro LB, Burns MB, Grenier JC, Lynch J, Grieneisen LE, Altmann J, Alberts SC, Blekhman R, Archie EA. Social networks predict gut microbiome composition in wild baboons. Elife. 2015 Mar 16; 4. PMID: 25774601; PMCID: PMC4379495.
      Citations: 195     Fields:    Translation:HumansAnimalsCells
    98. Tzelepis F, Verway M, Daoud J, Gillard J, Hassani-Ardakani K, Dunn J, Downey J, Gentile ME, Jaworska J, Sanchez AM, Vali H, Tabrizian M, Kristof AS, King IL, Barreiro LB, Divangahi M, Nédélec Y. Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest. 2015 Feb; 125(2):752-68. PMID: 25562320; PMCID: PMC4319406.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    99. Mandl JN, Ahmed R, Barreiro LB, Daszak P, Epstein JH, Virgin HW, Feinberg MB. Reservoir host immune responses to emerging zoonotic viruses. Cell. 2015 Jan 15; 160(1-2):20-35. PMID: 25533784; PMCID: PMC4390999.
      Citations: 70     Fields:    Translation:HumansAnimals
    100. Brinkworth JF, Barreiro LB. The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease. Curr Opin Immunol. 2014 Dec; 31:66-78. PMID: 25458997; PMCID: PMC4344185.
      Citations: 39     Fields:    Translation:HumansAnimals
    101. Barreiro LB, Quintana-Murci L. Editorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology. Curr Opin Immunol. 2014 Oct; 30:v-vii. PMID: 25240536.
      Citations:    Fields:    Translation:HumansAnimals
    102. Perry GH, Grenier JC, Patin E, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB, Foll M, Nédélec Y. Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers. Proc Natl Acad Sci U S A. 2014 09 02; 111(35):E3596-603. PMID: 25136101; PMCID: PMC4156716.
      Citations: 45     Fields:    Translation:Humans
    103. Pacis A, Nédélec Y, Barreiro LB. When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection. Curr Opin Immunol. 2014 Aug; 29:119-26. PMID: 24981784.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    104. Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B. Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12. J Immunol. 2014 Jul 15; 193(2):610-6. PMID: 24935923; PMCID: PMC4091631.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    105. Knowler SP, Platt S, Freeman C, Child G, Rouleau GA, Rusbridge C, Lemay P, Bouasker S, Nédélec Y, Barreiro LB, Kibar Z. Quantitative trait loci (QTL) study identifies novel genomic regions associated to Chiari-like malformation in Griffon Bruxellois dogs. PLoS One. 2014; 9(4):e89816. PMID: 24740420; PMCID: PMC3989173.
      Citations: 12     Fields:    Translation:Animals
    106. Patin E, Enard D, Barreiro LB, Quintana-Murci L, Laval G, Fagny M. Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets. Mol Biol Evol. 2014 Jul; 31(7):1850-68. PMID: 24694833.
      Citations: 41     Fields:    Translation:Humans
    107. Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y. Seasonal variation in human gut microbiome composition. PLoS One. 2014; 9(3):e90731. PMID: 24618913; PMCID: PMC3949691.
      Citations: 130     Fields:    Translation:Humans
    108. Barreiro LB, Dubois-Colas N, Petit-Jentreau L, Durand S, Soubigou G, Lecointe C, Klibi J, Rezaï K, Lokiec F, Coppée JY, Gicquel B, Tailleux L. Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis. J Infect Dis. 2014 Sep 01; 210(5):824-33. PMID: 24604822.
      Citations: 9     Fields:    Translation:HumansCells
    109. Siddle KJ, Deschamps M, Tailleux L, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Nédélec Y, Quintana-Murci L. A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection. Genome Res. 2014 May; 24(5):850-9. PMID: 24482540; PMCID: PMC4009614.
      Citations: 37     Fields:    Translation:HumansCells
    110. Patin E, Siddle KJ, Laval G, Harmant C, Froment A, Dominy NJ, Perry GH, Quach H, Becker N, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L. The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists. Nat Commun. 2014; 5:3163. PMID: 24495941.
      Citations: 43     Fields:    
    111. Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci L, Quach H. Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. Hum Mol Genet. 2013 Dec 01; 22(23):4829-40. PMID: 23851028; PMCID: PMC3820138.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    112. Orlova M, Huong NT, Ba NN, Van Thuc N, Spencer J, Barreiro L, Thai VH, Abel L, Schurr E, Cobat A, Nédélec Y, Alcaïs A. Gene set signature of reversal reaction type I in leprosy patients. PLoS Genet. 2013; 9(7):e1003624. PMID: 23874223; PMCID: PMC3708838.
      Citations: 22     Fields:    Translation:HumansCells
    113. El Baghdadi J, Sabri A, El Azbaoui S, Alaoui-Tahiri K, Abderrahmani Rhorfi I, Gharbaoui Y, Abid A, Benkirane M, Raharimanga V, Richard V, Orlova M, Boland A, Okada S, Nolan DK, Bustamante J, Barreiro LB, Schurr E, Boisson-Dupuis S, Rasolofo V, Casanova JL, Abel L, Grant AV, Migaud M. Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region. Am J Hum Genet. 2013 Mar 07; 92(3):407-14. PMID: 23415668; PMCID: PMC3591857.
      Citations: 30     Fields:    Translation:HumansCells
    114. Boulais J, Carruthers NJ, Landry CR, Jutras I, Duclos S, Michnick SW, Lajoie G, Barreiro L, Thibault P, Desjardins M, Goyette G, Dermine JF, LaBoissière S. Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution. Mol Cell Proteomics. 2012 Nov; 11(11):1365-77. PMID: 22915823; PMCID: PMC3494184.
      Citations: 9     Fields:    Translation:AnimalsCells
    115. Barreiro LB, Tung J. Getting under—and through—the skin: ecological genomics of chytridiomycosis infection in frogs. Mol Ecol. 2012 Jul; 21(13):3095-7. PMID: 22916344.
      Citations:    Fields:    Translation:Animals
    116. Tung J, Barreiro LB, Johnson ZP, Hansen KD, Michopoulos V, Toufexis D, Michelini K, Wilson ME, Gilad Y. Social environment is associated with gene regulatory variation in the rhesus macaque immune system. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6490-5. PMID: 22493251; PMCID: PMC3340061.
      Citations: 131     Fields:    Translation:AnimalsCells
    117. Barreiro LB, Tailleux L, Pai AA, Gicquel B, Marioni JC, Gilad Y. Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1204-9. PMID: 22233810; PMCID: PMC3268270.
      Citations: 145     Fields:    Translation:HumansCells
    118. Laval G, Patin E, Fornarino S, Itan Y, Fumagalli M, Sironi M, Tichit M, Bouchier C, Casanova JL, Barreiro LB, Quintana-Murci L, Manry J. Evolutionary genetic dissection of human interferons. J Exp Med. 2011 Dec 19; 208(13):2747-59. PMID: 22162829; PMCID: PMC3244034.
      Citations: 95     Fields:    Translation:HumansCTClinical Trials
    119. Jabri B, Barreiro LB. Don't move: LRRK2 arrests NFAT in the cytoplasm. Nat Immunol. 2011 Oct 19; 12(11):1029-30. PMID: 22012435.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    120. Fornarino S, Laval G, Barreiro LB, Manry J, Vasseur E, Quintana-Murci L. Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation. Mol Biol Evol. 2011 Nov; 28(11):3087-97. PMID: 21659570.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    121. Ben-Ali M, Corre B, Barreiro LB, Boniotto M, Pellegrini S, Manry J, Quach H, Quintana-Murci L. Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. Hum Mutat. 2011 Jun; 32(6):643-52. PMID: 21618349.
      Citations: 14     Fields:    Translation:HumansCells
    122. Laval G, Patin E, Fornarino S, Tichit M, Bouchier C, Barreiro LB, Quintana-Murci L, Manry J. Evolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity. Hum Mutat. 2011 Jun; 32(6):633-42. PMID: 21448974.
      Citations: 11     Fields:    Translation:HumansCells
    123. Sollid LM, Barreiro LB, Jabri B, Abadie V. Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol. 2011; 29:493-525. PMID: 21219178.
      Citations: 189     Fields:    Translation:HumansAnimals
    124. Barreiro LB, Marioni JC, Blekhman R, Stephens M, Gilad Y. Functional comparison of innate immune signaling pathways in primates. PLoS Genet. 2010 Dec 16; 6(12):e1001249. PMID: 21187902; PMCID: PMC3002988.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    125. Quintana-Murci L, Barreiro LB. The role played by natural selection on Mendelian traits in humans. Ann N Y Acad Sci. 2010 Dec; 1214:1-17. PMID: 21175682.
      Citations: 14     Fields:    Translation:Humans
    126. Laval G, Patin E, Barreiro LB, Quintana-Murci L. Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions. PLoS One. 2010 Apr 22; 5(4):e10284. PMID: 20421973; PMCID: PMC2858654.
      Citations: 38     Fields:    Translation:Humans
    127. Barreiro LB, Quintana-Murci L. From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet. 2010 Jan; 11(1):17-30. PMID: 19953080.
      Citations: 250     Fields:    Translation:HumansAnimals
    128. Ravel C, Chantot-Bastaraud S, Chalmey C, Barreiro L, Aknin-Seifer I, Pfeffer J, Berthaut I, Mathieu EE, Mandelbaum J, Siffroi JP, McElreavey K, Bashamboo A. Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts. PLoS One. 2009 Aug 06; 4(8):e6540. PMID: 19657388; PMCID: PMC2717325.
      Citations: 26     Fields:    Translation:HumansCells
    129. Barreiro LB, Ben-Ali M, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Ragimbeau J, Pellegrini S, Abel L, Casanova JL, Quach H, Alcaïs A, Quintana-Murci L. Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet. 2009 Jul; 5(7):e1000562. PMID: 19609346; PMCID: PMC2702086.
      Citations: 183     Fields:    Translation:Humans
    130. Patin E, Laval G, Barreiro LB, Salas A, Semino O, Santachiara-Benerecetti S, Kidd KK, Kidd JR, Van der Veen L, Hombert JM, Gessain A, Froment A, Bahuchet S, Heyer E, Quintana-Murci L. Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set. PLoS Genet. 2009 Apr; 5(4):e1000448. PMID: 19360089; PMCID: PMC2661362.
      Citations: 61     Fields:    Translation:Humans
    131. Barreiro LB, Laval G, Zidane N, Patin E, Kidd KK, Kidd JR, Bouchier C, Veuille M, Antoniewski C, Quach H, Quintana-Murci L. Signatures of purifying and local positive selection in human miRNAs. Am J Hum Genet. 2009 Mar; 84(3):316-27. PMID: 19232555; PMCID: PMC2667980.
      Citations: 46     Fields:    Translation:HumansCells
    132. Barreiro LB, Henriques R, Mhlanga MM. High-throughput SNP genotyping: combining tag SNPs and molecular beacons. Methods Mol Biol. 2009; 578:255-76. PMID: 19768600; PMCID: PMC7121513.
      Citations: 6     Fields:    Translation:Humans
    133. Zhang J, Zhang X, Fu J, Bi Z, Arheart KL, Barreiro LB, Quintana-Murci L, Pahwa S, Liu H. Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission. J Infect Dis. 2008 Jul 01; 198(1):68-71. PMID: 18510454.
      Citations: 5     Fields:    Translation:HumansCells
    134. Morilla A, Arias M, Barreiro L, Hidalgo F, Boga JA, de Oña M, Fernández-Verdugo A, González D, Melón S. Molecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain. J Clin Virol. 2008 Aug; 42(4):425-8. PMID: 18440271.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    135. Solloso A, Barreiro L, Seoane R, Nogueira E, Alvarez CV, Zalvide J, Pombo CM, Cañibano C, Diéguez C. GHRH proliferative action on somatotrophs is cell-type specific and dependent on Pit-1/GHF-1 expression. J Cell Physiol. 2008 Apr; 215(1):140-50. PMID: 17941086.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    136. Laval G, Patin E, Barreiro LB, Quach H, Quintana-Murci L. Natural selection has driven population differentiation in modern humans. Nat Genet. 2008 Mar; 40(3):340-5. PMID: 18246066.
      Citations: 276     Fields:    Translation:Humans
    137. Barreiro LB, Chabbou A, Haltiti R, Braham E, Neyrolles O, Dellagi K, Gicquel B, Quintana-Murci L, Barbouche MR, Ben-Ali M. Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. Hum Immunol. 2007 Nov; 68(11):908-12. PMID: 18082570.
      Citations: 15     Fields:    Translation:HumansCells
    138. Jouanguy E, Ugolini S, Smahi A, Romero P, Segal D, Sancho-Shimizu V, Lorenzo L, Puel A, Picard C, Chapgier A, Plancoulaine S, Titeux M, von Bernuth H, Ku CL, Casrouge A, Zhang XX, Barreiro L, Leonard J, Hamilton C, Lebon P, Quintana-Murci L, Hovnanian A, Rozenberg F, Vivier E, Tardieu M, Abel L, Casanova JL, Zhang SY, Elain G, Cognet C, Héron B, Vallée L, Geissmann F. TLR3 deficiency in patients with herpes simplex encephalitis. Science. 2007 Sep 14; 317(5844):1522-7. PMID: 17872438.
      Citations: 510     Fields:    Translation:HumansCells
    139. Barreiro LB, Neyrolles O, Babb CL, van Helden PD, Gicquel B, Hoal EG, Quintana-Murci L. Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility. Hum Immunol. 2007 Feb; 68(2):106-12. PMID: 17321900; PMCID: PMC7132702.
      Citations: 13     Fields:    Translation:HumansCells
    140. Barreiro LB, Quintana-Murci L. DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype. J Infect Dis. 2006 Oct 15; 194(8):1184-5; author reply 1185-7. PMID: 16991095.
      Citations: 7     Fields:    Translation:HumansCells
    141. Rosas-Magallanes V, Stadthagen-Gomez G, Rauzier J, Barreiro LB, Tailleux L, Griffin R, Jackson M, Gicquel B, Neyrolles O, Boudou F, Nigou J. Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infect Immun. 2007 Jan; 75(1):504-7. PMID: 17030567; PMCID: PMC1828433.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    142. Verdu P, Barreiro LB, Patin E, Gessain A, Cassar O, Kidd JR, Kidd KK, Behar DM, Froment A, Heyer E, Sica L, Casanova JL, Abel L, Quintana-Murci L. Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles. Hum Mol Genet. 2006 Sep 01; 15(17):2650-8. PMID: 16885193.
      Citations: 48     Fields:    Translation:Humans
    143. Barreiro LB, Krahenbuhl J, Khaliq S, Mohyuddin A, Mehdi SQ, Gicquel B, Neyrolles O, Quach H, Quintana-Murci L. DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population. Hum Immunol. 2006 Jan-Feb; 67(1-2):102-7. PMID: 16698431; PMCID: PMC7115659.
      Citations: 14     Fields:    Translation:HumansCells
    144. Patin E, Barreiro LB, Sabeti PC, Luca F, Sajantila A, Behar DM, Semino O, Sakuntabhai A, Guiso N, Gicquel B, McElreavey K, Harding RM, Heyer E, Quintana-Murci L, Austerlitz F. Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes. Am J Hum Genet. 2006 Mar; 78(3):423-36. PMID: 16416399; PMCID: PMC1380286.
      Citations: 42     Fields:    Translation:HumansCells
    145. Barreiro LB, Neyrolles O, Babb CL, Tailleux L, McElreavey K, Helden PD, Hoal EG, Gicquel B, Quintana-Murci L, Quach H. Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med. 2006 Feb; 3(2):e20. PMID: 16379498; PMCID: PMC1324949.
      Citations: 76     Fields:    Translation:HumansCells
    146. Barreiro LB, Patin E, Neyrolles O, Cann HM, Gicquel B, Quintana-Murci L. The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region. Am J Hum Genet. 2005 Nov; 77(5):869-86. PMID: 16252244; PMCID: PMC1271393.
      Citations: 46     Fields:    Translation:HumansCells
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