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Christos Lazaridis

AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    A neurointensivist, Dr. Christos Lazaridis is interested in all aspects of care for critically ill neurological and neurosurgical patients; specific clinical and research interests include neuromonitoring and management of traumatic brain injury, and neurocritical care ethics. He enjoys teaching fellows, residents and medical students in general and neuro-critical care.


    Collapse Biography 
    Collapse education and training
    Pécs University Medical School, Pécs, HungaryMD08/2001Medicine
    University of Texas, Southwestern Medical School, Dallas, TX06/2006Neurology
    Johns Hopkins University, Baltimore, MD06/2008Neurocritical Care
    Cambridge University, Cambridge, UK01/2012Neurotrauma Critical Care (6mo)
    University of Toronto, Sunnybrook Hospital, Toronto, Canada05/2016Critical Care Medicine (6mo)
    Collapse awards and honors
    2011European Diploma in Intensive Care, European Society of Intensive Care Medicine

    Collapse ORNG Applications 
    Collapse Featured Presentations

    Collapse Research 
    Collapse research activities and funding
    1U01NS099046-01A1     (Diaz-Arrastia)
    NIH
    Brain Oxygen Optimization in Severe TBI Phase-3
    Role Description: Randomized controlled trial testing the co-management of brain tissue oxygenation and intracranial pressure vs. ICP alone in severe TBI
    Role: Clinical PI for U of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lazaridis C, Goldenberg FD. Intracranial Pressure in Traumatic Brain Injury: From Thresholds to Heuristics. Crit Care Med. 2020 Aug; 48(8):1210-1213. PMID: 32697493.
      View in: PubMed
    2. Loggini A, Mansour A, El Ammar F, Lazaridis C, Kramer CL, Bulwa Z, Saleh Velez F, McCoy C, Goldenberg FD. Early Determinants of Neurocritical Care Unit Length of Stay in Patients with Spontaneous Intracerebral Hemorrhage. Neurocrit Care. 2020 Jul 10. PMID: 32651738.
      View in: PubMed
    3. Lazaridis C. Comment on "Worse Than Death: Survey of Public Perceptions of Disability Outcomes After Hypothetical Traumatic Brain Injury". Ann Surg. 2020 Jun 11. PMID: 32541214.
      View in: PubMed
    4. Lazaridis C. Accommodating Apnea Testing Not Death Determination Refusal. Am J Bioeth. 2020 06; 20(6):47-49. PMID: 32618509.
      View in: PubMed
    5. Lazaridis C, Desai M, Damoulakis G, Zeiler FA. Intracranial Pressure Threshold Heuristics in Traumatic Brain Injury: One, None, Many! Neurocrit Care. 2020 06; 32(3):672-676. PMID: 32141033.
      View in: PubMed
    6. Lazaridis C, Goldenberg FD. Intracranial Pressure in Traumatic Brain Injury: From Thresholds to Heuristics. Crit Care Med. 2020 Apr 28. PMID: 32345832.
      View in: PubMed
    7. Loggini A, Tangonan R, El Ammar F, Mansour A, Goldenberg FD, Kramer CL, Lazaridis C. The role of amantadine in cognitive recovery early after traumatic brain injury: A systematic review. Clin Neurol Neurosurg. 2020 Jul; 194:105815. PMID: 32244036.
      View in: PubMed
    8. Suarez JI, Martin RH, Bauza C, Georgiadis A, Venkatasubba Rao CP, Calvillo E, Hemphill JC, Sung G, Oddo M, Taccone FS, LeRoux PD. Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1. Neurocrit Care. 2020 02; 32(1):172-179. PMID: 31175567.
      View in: PubMed
    9. Loggini A, Vasenina VI, Mansour A, Das P, Horowitz PM, Goldenberg FD, Kramer C, Lazaridis C. Management of civilians with penetrating brain injury: A systematic review. J Crit Care. 2020 Apr; 56:159-166. PMID: 31923862.
      View in: PubMed
    10. Lazaridis C. Intracranial Pressure Monitoring in Traumatic Brain Injury: Start Ventricular or Parenchymal? Neurocrit Care. 2019 08; 31(1):22-23. PMID: 31025185.
      View in: PubMed
    11. Zeiler FA, Ercole A, Cabeleira M, Beqiri E, Zoerle T, Carbonara M, Stocchetti N, Menon DK, Lazaridis C, Smielewski P, Czosnyka M. Patient-specific ICP Epidemiologic Thresholds in Adult Traumatic Brain Injury: A CENTER-TBI Validation Study. J Neurosurg Anesthesiol. 2019 Jun 18. PMID: 31219937.
      View in: PubMed
    12. Lazaridis C. Withdrawal of Life-Sustaining Treatments in Perceived Devastating Brain Injury: The Key Role of Uncertainty. Neurocrit Care. 2019 02; 30(1):33-41. PMID: 30143963.
      View in: PubMed
    13. Lazaridis C. Letter to the Editor. Reanalyze BEST TRIP. J Neurosurg. 2019 01 18; 131(2):652. PMID: 30660126.
      View in: PubMed
    14. Lazaridis C. End-of-life Considerations and Shared Decision Making in Neurocritical Care. Continuum (Minneap Minn). 2018 12; 24(6):1794-1799. PMID: 30516607.
      View in: PubMed
    15. Lazaridis C, Altaweel L, Karakitsos D. Updates in Neurocritical Care. Crit Care Res Pract. 2018; 2018:1617359. PMID: 30155293.
      View in: PubMed
    16. Lazaridis C, Rusin CG, Robertson CS. Secondary brain injury: Predicting and preventing insults. Neuropharmacology. 2019 02; 145(Pt B):145-152. PMID: 29885419.
      View in: PubMed
    17. Lazaridis C. Brain Injured and Heart Strained. Crit Care Med. 2018 06; 46(6):1023-1024. PMID: 29762407.
      View in: PubMed
    18. Soliman I, Johnson GGRJ, Gillman LM, Zeiler FA, Faqihi F, Aletreby WT, Balhamar A, Mahmood NN, Ahmad Mumtaz S, Alharthy A, Lazaridis C, Karakitsos D. New Optic Nerve Sonography Quality Criteria in the Diagnostic Evaluation of Traumatic Brain Injury. Crit Care Res Pract. 2018; 2018:3589762. PMID: 29854448.
      View in: PubMed
    19. Kazmi SO, Sivakumar S, Karakitsos D, Alharthy A, Lazaridis C. Cerebral Pathophysiology in Extracorporeal Membrane Oxygenation: Pitfalls in Daily Clinical Management. Crit Care Res Pract. 2018; 2018:3237810. PMID: 29744226.
      View in: PubMed
    20. Okonkwo DO, Shutter LA, Moore C, Temkin NR, Puccio AM, Madden CJ, Andaluz N, Chesnut RM, Bullock MR, Grant GA, McGregor J, Weaver M, Jallo J, LeRoux PD, Moberg D, Barber J, Lazaridis C, Diaz-Arrastia RR. Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial. Crit Care Med. 2017 Nov; 45(11):1907-1914. PMID: 29028696.
      View in: PubMed
    21. Fam MD, Zeineddine HA, Eliyas JK, Stadnik A, Jesselson M, McBee N, Lane K, Cao Y, Wu M, Zhang L, Thompson RE, John S, Ziai W, Hanley DF, Awad IA. CSF inflammatory response after intraventricular hemorrhage. Neurology. 2017 Oct 10; 89(15):1553-1560. PMID: 28887375.
      View in: PubMed
    22. Lazaridis C. Ending Life in the ICU: The Vacuity of Sanctity. Crit Care Med. 2017 06; 45(6):e628. PMID: 28509755.
      View in: PubMed
    23. Koch PM, Lazaridis C. What does it mean for a critically ill patient to fare well? Intensive Care Med. 2017 10; 43(10):1518-1519. PMID: 28500453.
      View in: PubMed
    24. Lazaridis C. Resuscitation Versus Donation: Conflict, Priority, and Rational Consent. Am J Bioeth. 2017 05; 17(5):27-29. PMID: 28430062.
      View in: PubMed
    25. Sivakumar S, Taccone FS, Rehman M, Hinson H, Naval N, Lazaridis C. Hemodynamic and neuro-monitoring for neurocritically ill patients: An international survey of intensivists. J Crit Care. 2017 06; 39:40-47. PMID: 28171804.
      View in: PubMed
    26. Quiñones-Hinojosa A, Raza SM, Lazaridis C, Olivi A. Olfactory Groove Meningiomas: Acute Presentation and Potential : Pitfalls in Management and Functional Restoration. Acta Neurochir Suppl. 2017; 124:155-158. PMID: 28120068.
      View in: PubMed
    27. Lazaridis C. Diffusion Hypoxia and/or Primary Mitochondrial Failure? JAMA Neurol. 2016 11 01; 73(11):1372-1373. PMID: 27618519.
      View in: PubMed
    28. Lazaridis C. Cerebral oxidative metabolism failure in traumatic brain injury: "Brain shock". J Crit Care. 2017 02; 37:230-233. PMID: 27773372.
      View in: PubMed
    29. Lazaridis C, Robertson CS. The Role of Multimodal Invasive Monitoring in Acute Traumatic Brain Injury. Neurosurg Clin N Am. 2016 Oct; 27(4):509-17. PMID: 27637400.
      View in: PubMed
    30. Myers RB, Lazaridis C, Jermaine CM, Robertson CS, Rusin CG. Predicting Intracranial Pressure and Brain Tissue Oxygen Crises in Patients With Severe Traumatic Brain Injury. Crit Care Med. 2016 09; 44(9):1754-61. PMID: 27315192.
      View in: PubMed
    31. Lazaridis C, Robertson CS. Hypothermia for Increased Intracranial Pressure: Is It Dead? Curr Neurol Neurosci Rep. 2016 09; 16(9):78. PMID: 27443645.
      View in: PubMed
    32. Lazaridis C. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury. N Engl J Med. 2016 04 07; 374(14):1384. PMID: 27050214.
      View in: PubMed
    33. Blumenthal-Barby JS, Lazaridis C. A Woman in Her 30s Whose Family Becomes Distrustful After an Initial Prognosis Proves Inaccurate. Chest. 2016 Apr; 149(4):e115-7. PMID: 27055715.
      View in: PubMed
    34. Lazaridis C. Transforming ICU death into life-radically more. Intensive Care Med. 2016 Dec; 42(12):2096-2097. PMID: 27000387.
      View in: PubMed
    35. Lazaridis C, Smielewski P, Menon DK, Hutchinson P, Pickard JD, Czosnyka M. Patient-Specific Thresholds and Doses of Intracranial Hypertension in Severe Traumatic Brain Injury. Acta Neurochir Suppl. 2016; 122:117-20. PMID: 27165889.
      View in: PubMed
    36. Lazaridis C, Yang M, DeSantis SM, Luo ST, Robertson CS. Predictors of intensive care unit length of stay and intracranial pressure in severe traumatic brain injury. J Crit Care. 2015 Dec; 30(6):1258-62. PMID: 26324412.
      View in: PubMed
    37. Lazaridis C. "No-touch" period: no benefit for donors, high cost for recipients. Intensive Care Med. 2016 Jan; 42(1):134. PMID: 26179430.
      View in: PubMed
    38. Lazaridis C, Maas AI, Souter MJ, Martin RH, Chesnut RM, DeSantis SM, Sung G, Leroux PD, Suarez JI. Alternative clinical trial design in neurocritical care. Neurocrit Care. 2015 Jun; 22(3):378-84. PMID: 25894451.
      View in: PubMed
    39. Citerio G, Park S, Schmidt JM, Moberg R, Suarez JI, Le Roux PD. Data collection and interpretation. Neurocrit Care. 2015 Jun; 22(3):360-8. PMID: 25846711.
      View in: PubMed
    40. Georgiadis AL, Palesch YY, Zygun D, Hemphill JC, Robertson CS, Leroux PD, Suarez JI. Multi-modality neuro-monitoring: conventional clinical trial design. Neurocrit Care. 2015 Jun; 22(3):369-77. PMID: 25832350.
      View in: PubMed
    41. Frontera J, Ziai W, O'Phelan K, Leroux PD, Kirkpatrick PJ, Diringer MN, Suarez JI. Regional brain monitoring in the neurocritical care unit. Neurocrit Care. 2015 Jun; 22(3):348-59. PMID: 25832349.
      View in: PubMed
    42. Lazaridis C. Routine recovery of organs for transplantation can be acceptable. Intensive Care Med. 2015 Jun; 41(6):1152. PMID: 25971376.
      View in: PubMed
    43. Bershad EM, Rao CP, Vuong KD, Mazabob J, Brown G, Styron SL, Nguyen T, Delledera E, Smirnakis SM, Lazaridis C, Georgiadis AL, Mokracek M, Seipel TJ, Nisbet JJ, Baskaran V, Chang AH, Stewart P, Suarez JI. Multidisciplinary protocol for rapid head computed tomography turnaround time in acute stroke patients. J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1256-61. PMID: 25920753.
      View in: PubMed
    44. Shah V, Lazaridis C. Apnea testing on extracorporeal membrane oxygenation: Case report and literature review. J Crit Care. 2015 Aug; 30(4):784-6. PMID: 25891646.
      View in: PubMed
    45. Lazaridis C. Where was I when I was in a coma? Intensive Care Med. 2015 Nov; 41(11):1971-2. PMID: 25711472.
      View in: PubMed
    46. Lazaridis C, Blumenthal-Barby JS. Organ Donation Beyond Brain Death: Donors as Ends and Maximal Utility. Am J Bioeth. 2015; 15(8):17-9. PMID: 26225507.
      View in: PubMed
    47. Lazaridis C, Blumenthal-Barby JS. Biology, metaphysics, and brain death criteria. J Crit Care. 2015 Apr; 30(2):417-8. PMID: 25599946.
      View in: PubMed
    48. Lazaridis C, Andrews CM. Brain tissue oxygenation, lactate-pyruvate ratio, and cerebrovascular pressure reactivity monitoring in severe traumatic brain injury: systematic review and viewpoint. Neurocrit Care. 2014 Oct; 21(2):345-55. PMID: 24993955.
      View in: PubMed
    49. Lazaridis C. The living brain dead. Intensive Care Med. 2014 Nov; 40(11):1791. PMID: 25186985.
      View in: PubMed
    50. Lazaridis C. From targeting to optimizing cerebral perfusion pressure. Crit Care Med. 2014 Sep; 42(9):e635. PMID: 25126820.
      View in: PubMed
    51. Lazaridis C, Czosnyka M. Patient-specific intracranial pressure. Response. J Neurosurg. 2014 Apr; 120(4):892. PMID: 24809078.
      View in: PubMed
    52. Lazaridis C, Andrews CM. Traumatic spinal cord injury: learn from the brain!*. Crit Care Med. 2014 Mar; 42(3):749-50. PMID: 24534971.
      View in: PubMed
    53. Lazaridis C, DeSantis SM, Smielewski P, Menon DK, Hutchinson P, Pickard JD, Czosnyka M. Patient-specific thresholds of intracranial pressure in severe traumatic brain injury. J Neurosurg. 2014 Apr; 120(4):893-900. PMID: 24506248.
      View in: PubMed
    54. Desantis SM, Lazaridis C, Ji S, Spinale FG. Analyzing Propensity Matched Zero-Inflated Count Outcomes in Observational Studies. J Appl Stat. 2014 Jan 01; 41(1). PMID: 24298197.
      View in: PubMed
    55. Lazaridis C. Plateau waves of intracranial pressure and mechanisms of brain hypoxia. J Crit Care. 2014 Apr; 29(2):303-4. PMID: 24411105.
      View in: PubMed
    56. DeSantis SM, Lazaridis C. Aprotinin revisited. Intensive Care Med. 2014 Jan; 40(1):142. PMID: 24154674.
      View in: PubMed
    57. Graffagnino C, Bergese S, Love J, Schneider D, Lazaridis C, LaPointe M, Lee K, Lynch G, Hu MY, Williams GC. Clevidipine rapidly and safely reduces blood pressure in acute intracerebral hemorrhage: the ACCELERATE trial. Cerebrovasc Dis. 2013; 36(3):173-80. PMID: 24135526.
      View in: PubMed
    58. Madey JJ, Hannah JA, Lazaridis C. Central pontine myelinolysis following acute hypoglycemia. Clin Neurol Neurosurg. 2013 Oct; 115(10):2299-300. PMID: 23948485.
      View in: PubMed
    59. Desantis SM, Lazaridis C, Palesch Y, Ramakrishnan V. Regression analysis of ordinal stroke clinical trial outcomes: an application to the NINDS t-PA trial. Int J Stroke. 2014 Feb; 9(2):226-31. PMID: 23803174.
      View in: PubMed
    60. Lazaridis C, Neyens R, Bodle J, DeSantis SM. High-osmolarity saline in neurocritical care: systematic review and meta-analysis. Crit Care Med. 2013 May; 41(5):1353-60. PMID: 23591212.
      View in: PubMed
    61. Lazaridis C, Smielewski P, Steiner LA, Brady KM, Hutchinson P, Pickard JD, Czosnyka M. Optimal cerebral perfusion pressure: are we ready for it? Neurol Res. 2013 Mar; 35(2):138-48. PMID: 23452576.
      View in: PubMed
    62. Turk AS, Nyberg EM, Chaudry MI, Turner RD, Magarik JA, Nicholas JS, Holmstedt CA, Chalela JA, Hays A, Lazaridis C, Chimowitz MI, Turan TN, Adams RJ, Jauch EC. Utilization of CT perfusion patient selection for mechanical thrombectomy irrespective of time: a comparison of functional outcomes and complications. J Neurointerv Surg. 2013 Nov; 5(6):518-22. PMID: 22935349.
      View in: PubMed
    63. Lazaridis C, Czosnyka M. Cerebral blood flow, brain tissue oxygen, and metabolic effects of decompressive craniectomy. Neurocrit Care. 2012 Jun; 16(3):478-84. PMID: 22396191.
      View in: PubMed
    64. Lazaridis C, DeSantis SM, Vandergrift AW, Krishna V. Cerebral blood flow velocity changes and the value of the pulsatility index post decompressive craniectomy. J Clin Neurosci. 2012 Jul; 19(7):1052-4. PMID: 22555129.
      View in: PubMed
    65. Adams RJ, Debenham E, Chalela J, Chimowitz M, Hays A, Hill C, Holmstedt C, Jauch E, Kitch A, Lazaridis C, Turan TN. REACH MUSC: A Telemedicine Facilitated Network for Stroke: Initial Operational Experience. Front Neurol. 2012; 3:33. PMID: 22435064.
      View in: PubMed
    66. Krishna V, Lazaridis C, Ellegala D, Glazier S, Kindy M, Spampinato M, Chalela JA. Spinal cord infarction associated with subarachnoid hemorrhage. Clin Neurol Neurosurg. 2012 Sep; 114(7):1030-2. PMID: 22386902.
      View in: PubMed
    67. Lazaridis C. Advanced hemodynamic monitoring: principles and practice in neurocritical care. Neurocrit Care. 2012 Feb; 16(1):163-9. PMID: 21678100.
      View in: PubMed
    68. Lazaridis C, DeSantis SM, Jauch EC, Adams RJ. Telestroke in South Carolina. J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):946-50. PMID: 22196873.
      View in: PubMed
    69. Lazaridis C, DeSantis SM, McLawhorn M, Krishna V. Liberation of neurosurgical patients from mechanical ventilation and tracheostomy in neurocritical care. J Crit Care. 2012 Aug; 27(4):417.e1-8. PMID: 22033050.
      View in: PubMed
    70. Turk A, Magarik JA, Chaudry I, Turner RD, Nicholas J, Holmstedt CA, Chalela J, Hays A, Lazaridis C, Jauch E, Chimowitz M, Turan T, Adams R. CT perfusion-guided patient selection for endovascular treatment of acute ischemic stroke is safe and effective. J Neurointerv Surg. 2012 Jul; 4(4):261-5. PMID: 21990520.
      View in: PubMed
    71. Lazaridis C, Bodle J, Chaudry I, Hays A, Chalela J. Familial nontraumatic, nonaneurysmal subarachnoid hemorrhage: a report on three first-degree siblings. J Neurosurg. 2011 Sep; 115(3):621-3. PMID: 21639697.
      View in: PubMed
    72. Hays AN, Lazaridis C, Neyens R, Nicholas J, Gay S, Chalela JA. Osmotherapy: use among neurointensivists. Neurocrit Care. 2011 Apr; 14(2):222-8. PMID: 21153930.
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    73. Lazaridis C, Pradilla G, Nyquist PA, Tamargo RJ. Intra-aortic balloon pump counterpulsation in the setting of subarachnoid hemorrhage, cerebral vasospasm, and neurogenic stress cardiomyopathy. Case report and review of the literature. Neurocrit Care. 2010 Aug; 13(1):101-8. PMID: 20383610.
      View in: PubMed
    74. Lazaridis C, Naval N. Risk factors and medical management of vasospasm after subarachnoid hemorrhage. Neurosurg Clin N Am. 2010 Apr; 21(2):353-64. PMID: 20380975.
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    75. Aravapalli A, Fox J, Lazaridis C. Cerebral fat embolism and the "starfield" pattern: a case report. Cases J. 2009 Nov 19; 2:212. PMID: 19946456.
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    76. Chik Y, Hoesch RE, Lazaridis C, Weisman CJ, Llinas RH. A case of postpartum cerebral angiopathy with subarachnoid hemorrhage. Nat Rev Neurol. 2009 Sep; 5(9):512-6. PMID: 19724301.
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    77. Lazaridis C, Hays AN, Neyens R, Chalela JA. Liberation from mechanical ventilation in the neurocritically ill. Crit Care Med. 2009 Apr; 37(4):1531; author reply 1532. PMID: 19318858.
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    78. Stevens RD, Lazaridis C, Chalela JA. The role of mechanical ventilation in acute brain injury. Neurol Clin. 2008 May; 26(2):543-63, x. PMID: 18514826.
      View in: PubMed
    79. Singer MA, Lazaridis C, Nations SP, Wolfe GI. Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review. Muscle Nerve. 2008 Jan; 37(1):125-9. PMID: 17623854.
      View in: PubMed
    80. Lazaridis C, Geocadin R, Mirski M. An association between hypernatremia, adverse cardiac outcomes and mortality in patients with subarachnoid hemorrhage. Neurocrit Care. 2007; 7(3):270-1; author reply 272. PMID: 17975712.
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    81. Lazaridis C, Torabi A, Cannon S. Bilateral third nerve palsy and temporal arteritis. Arch Neurol. 2005 Nov; 62(11):1766-8. PMID: 16286553.
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    82. Pavlidis TE, Atmatzidis KS, Lazaridis CN, Papaziogas BT, Makris JG, Papaziogas TB. Comparison between modern mesh and conventional non-mesh methods of inguinal hernia repair. Minerva Chir. 2002 Feb; 57(1):7-12. PMID: 11832851.
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