 Metallothionein
"Metallothionein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.
| Descriptor ID |
D008668
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| MeSH Number(s) |
D12.776.556.670
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Metallothionein".
Below are MeSH descriptors whose meaning is more specific than "Metallothionein".
This graph shows the total number of publications written about "Metallothionein" by people in this website by year, and whether "Metallothionein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metallothionein" by people in Profiles.
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de Francisco P, Martín-González A, Turkewitz AP, Gutiérrez JC. Extreme metal adapted, knockout and knockdown strains reveal a coordinated gene expression among different Tetrahymena thermophila metallothionein isoforms. PLoS One. 2017; 12(12):e0189076.
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Accornero F, Kanisicak O, Tjondrokoesoemo A, Attia AC, McNally EM, Molkentin JD. Myofiber-specific inhibition of TGFß signaling protects skeletal muscle from injury and dystrophic disease in mice. Hum Mol Genet. 2014 Dec 20; 23(25):6903-15.
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Amaro F, Turkewitz AP, Martín-González A, Gutiérrez JC. Functional GFP-metallothionein fusion protein from Tetrahymena thermophila: a potential whole-cell biosensor for monitoring heavy metal pollution and a cell model to study metallothionein overproduction effects. Biometals. 2014 Feb; 27(1):195-205.
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Amaro F, Turkewitz AP, Martín-González A, Gutiérrez JC. Whole-cell biosensors for detection of heavy metal ions in environmental samples based on metallothionein promoters from Tetrahymena thermophila. Microb Biotechnol. 2011 Jul; 4(4):513-22.
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Esser-Kahn AP, Iavarone AT, Francis MB. Metallothionein-cross-linked hydrogels for the selective removal of heavy metals from water. J Am Chem Soc. 2008 Nov 26; 130(47):15820-2.
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Xie T, Tong L, McCann UD, Yuan J, Becker KG, Mechan AO, Cheadle C, Donovan DM, Ricaurte GA. Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons. J Neurosci. 2004 Aug 11; 24(32):7043-50.
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Butt A, Mousley C, Morris K, Beynon J, Can C, Holub E, Greenberg JT, Buchanan-Wollaston V. Differential expression of a senescence-enhanced metallothionein gene in Arabidopsis in response to isolates of Peronospora parasitica and Pseudomonas syringae. Plant J. 1998 Oct; 16(2):209-21.
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Engler P, Roth P, Kim JY, Storb U. Factors affecting the rearrangement efficiency of an Ig test gene. J Immunol. 1991 Apr 15; 146(8):2826-35.
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Kushner PJ, Hort E, Shine J, Baxter JD, Greene GL. Construction of cell lines that express high levels of the human estrogen receptor and are killed by estrogens. Mol Endocrinol. 1990 Oct; 4(10):1465-73.
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Gounari F, Banks GR, Khazaie K, Jeggo PA, Holliday R. Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants. Genes Dev. 1987 Nov; 1(9):899-912.
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