"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D008247
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| MeSH Number(s) |
A11.284.430.214.190.875.190.550
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 3 | 1 | 4 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 2 | 2 |
| 2012 | 3 | 1 | 4 |
| 2013 | 1 | 3 | 4 |
| 2014 | 0 | 2 | 2 |
| 2015 | 2 | 6 | 8 |
| 2016 | 0 | 3 | 3 |
| 2017 | 2 | 1 | 3 |
| 2018 | 3 | 2 | 5 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 3 | 4 |
| 2021 | 2 | 3 | 5 |
| 2022 | 1 | 4 | 5 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 2 | 3 |
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Below are the most recent publications written about "Lysosomes" by people in Profiles.
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Large lysosomes in Chédiak-Higashi syndrome. Kidney Int. 2024 Aug; 106(2):320.
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Reduction of spermine synthase enhances autophagy to suppress Tau accumulation. Cell Death Dis. 2024 May 13; 15(5):333.
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A mechanism of lysosomal calcium entry. Sci Adv. 2024 Feb 16; 10(7):eadk2317.
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A DNA nanodevice for mapping sodium at single-organelle resolution. Nat Biotechnol. 2024 Jul; 42(7):1075-1083.
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Three-dimensional structured illumination microscopy with enhanced axial resolution. Nat Biotechnol. 2023 09; 41(9):1307-1319.
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The evolution of organellar calcium mapping technologies. Cell Calcium. 2022 12; 108:102658.
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LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2205629119.
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Phenotypic and genetic spectrum of ATP6V1A encephalopathy: a disorder of lysosomal homeostasis. Brain. 2022 08 27; 145(8):2687-2703.
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A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila. PLoS Genet. 2022 05; 18(5):e1010194.
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Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. J Biol Chem. 2022 03; 298(3):101673.