"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D008247
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| MeSH Number(s) |
A11.284.430.214.190.875.190.550
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 3 | 1 | 4 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 2 | 3 |
| 2010 | 0 | 2 | 2 |
| 2012 | 3 | 1 | 4 |
| 2013 | 1 | 3 | 4 |
| 2014 | 0 | 3 | 3 |
| 2015 | 2 | 6 | 8 |
| 2016 | 1 | 3 | 4 |
| 2017 | 2 | 1 | 3 |
| 2018 | 3 | 2 | 5 |
| 2019 | 3 | 1 | 4 |
| 2020 | 2 | 3 | 5 |
| 2021 | 2 | 4 | 6 |
| 2022 | 1 | 5 | 6 |
| 2023 | 0 | 2 | 2 |
| 2024 | 3 | 2 | 5 |
| 2025 | 1 | 2 | 3 |
| 2026 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Lysosomes" by people in Profiles.
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Peroxisome-derived ether lipids regulate lysosomal exocytosis. EMBO J. 2026 Jun; 45(11):3699-3730.
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Maturation stage-specific V-ATPase disassembly explains the neutral pH of mature mucocyst lysosome-related organelles in Tetrahymena thermophila. J Cell Sci. 2025 12 01; 138(23).
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Phagosome Maturation in Macrophages is Enhanced by p38a MAPK Signaling. Small. 2025 11; 21(44):e06883.
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Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover. J Biol Chem. 2025 07; 301(7):110322.
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Multimodal Blood-Based Biomarker Panel Reveals Altered Lysosomal Ionic Content in Alzheimer's Disease. ACS Chem Biol. 2025 01 17; 20(1):137-152.
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An SLC12A9-dependent ion transport mechanism maintains lysosomal osmolarity. Dev Cell. 2025 01 20; 60(2):220-235.e7.
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Large lysosomes in Chédiak-Higashi syndrome. Kidney Int. 2024 08; 106(2):320.
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Reduction of spermine synthase enhances autophagy to suppress Tau accumulation. Cell Death Dis. 2024 05 13; 15(5):333.
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A mechanism of lysosomal calcium entry. Sci Adv. 2024 02 16; 10(7):eadk2317.
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A DNA nanodevice for mapping sodium at single-organelle resolution. Nat Biotechnol. 2024 Jul; 42(7):1075-1083.