"Lactoylglutathione Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.
| Descriptor ID |
D007791
|
| MeSH Number(s) |
D08.811.520.300.500
|
| Concept/Terms |
Lactoylglutathione Lyase- Lactoylglutathione Lyase
- Lyase, Lactoylglutathione
- Methylglyoxalase
- Glyoxalase I
- Lactoyl Glutathione Lyase
- Glutathione Lyase, Lactoyl
- Lyase, Lactoyl Glutathione
|
Below are MeSH descriptors whose meaning is more general than "Lactoylglutathione Lyase".
Below are MeSH descriptors whose meaning is more specific than "Lactoylglutathione Lyase".
This graph shows the total number of publications written about "Lactoylglutathione Lyase" by people in this website by year, and whether "Lactoylglutathione Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lactoylglutathione Lyase" by people in Profiles.
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Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Nat Commun. 2019 12 06; 10(1):5604.
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Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice. Behav Brain Res. 2016 Mar 15; 301:119-23.
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Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development. Biochem Soc Trans. 2014 Apr; 42(2):461-7.
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Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility. Epilepsia. 2013 Apr; 54(4):649-57.
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Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal. J Clin Invest. 2012 Jun; 122(6):2306-15.
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A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior. PLoS One. 2009; 4(3):e4649.