Transcription Factor 7-Like 2 Protein
"Transcription Factor 7-Like 2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN. Transcription factor 7-like 2 protein plays an important role in the embryogenesis of the PANCREAS and ISLET CELLS.
| Descriptor ID |
D058118
|
| MeSH Number(s) |
D12.776.260.730.875 D12.776.660.235.400.800.875 D12.776.664.235.400.800.875 D12.776.930.875.875
|
| Concept/Terms |
Transcription Factor 7-Like 2 Protein- Transcription Factor 7-Like 2 Protein
- Transcription Factor 7 Like 2 Protein
- T-Cell-Specific Transcription Factor 4
- T Cell Specific Transcription Factor 4
- T Cell Transcription Factor 4
- TCF7L2 Transcription Factor
- Transcription Factor, TCF7L2
- T Cell Factor 4
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor 7-Like 2 Protein".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor 7-Like 2 Protein".
This graph shows the total number of publications written about "Transcription Factor 7-Like 2 Protein" by people in this website by year, and whether "Transcription Factor 7-Like 2 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transcription Factor 7-Like 2 Protein" by people in Profiles.
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Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021 09 02; 108(9):1578-1589.
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TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia. Arterioscler Thromb Vasc Biol. 2019 02; 39(2):250-262.
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Genetic Background Limits Generalizability of Genotype-Phenotype Relationships. Neuron. 2016 Sep 21; 91(6):1253-1259.
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Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice. Hum Mol Genet. 2015 Mar 15; 24(6):1646-54.
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TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet. 2014 Dec 15; 23(24):6419-31.
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TCF7L2 and glucose metabolism: time to look beyond the pancreas. Diabetes. 2013 Mar; 62(3):706-8.
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In vitro scan for enhancers at the TCF7L2 locus. Diabetologia. 2013 Jan; 56(1):121-5.
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Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS. Obesity (Silver Spring). 2012 Jun; 20(6):1273-8.
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Modulation ofTcf7l2 expression alters behavior in mice. PLoS One. 2011; 6(10):e26897.
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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res. 2011 Sep; 21(9):1417-25.