Procollagen-Proline Dioxygenase
"Procollagen-Proline Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
Descriptor ID |
D011393
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MeSH Number(s) |
D08.811.682.690.708.673
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Concept/Terms |
Procollagen-Proline Dioxygenase- Procollagen-Proline Dioxygenase
- Dioxygenase, Procollagen-Proline
- Procollagen Proline Dioxygenase
- Procollagen Prolyl 4-Hydroxylase
- 4-Hydroxylase, Procollagen Prolyl
- Procollagen Prolyl 4 Hydroxylase
- Prolyl 4-Hydroxylase, Procollagen
- Protocollagen Prolyl Hydroxylase
- Hydroxylase, Protocollagen Prolyl
- Prolyl Hydroxylase, Protocollagen
- Proline,2-Oxoglutarate 4-Dioxygenase
- 4-Dioxygenase, Proline,2-Oxoglutarate
- Proline,2 Oxoglutarate 4 Dioxygenase
- Prolyl 4-Hydroxylase
- 4-Hydroxylase, Prolyl
- Prolyl 4 Hydroxylase
- Prolyl Hydroxylase
- Hydroxylase, Prolyl
- Peptidyl Prolyl Hydroxylase
- Hydroxylase, Peptidyl Prolyl
- Prolyl Hydroxylase, Peptidyl
- Proline Hydroxylase
- Hydroxylase, Proline
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Below are MeSH descriptors whose meaning is more general than "Procollagen-Proline Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "Procollagen-Proline Dioxygenase".
This graph shows the total number of publications written about "Procollagen-Proline Dioxygenase" by people in this website by year, and whether "Procollagen-Proline Dioxygenase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2006 | 0 | 1 | 1 | 2007 | 0 | 1 | 1 | 2008 | 1 | 0 | 1 | 2010 | 1 | 0 | 1 | 2012 | 0 | 1 | 1 | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Procollagen-Proline Dioxygenase" by people in Profiles.
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Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M. Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence. Cell Rep. 2018 06 19; 23(12):3565-3578.
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Kumar GS, Chang W, Xie T, Patel A, Zhang Y, Wang GG, David G, Radhakrishnan I. Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. J Mol Biol. 2012 Sep 28; 422(4):519-31.
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Park AM, Sanders TA, Maltepe E. Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care. Semin Fetal Neonatal Med. 2010 Aug; 15(4):196-202.
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Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol. 2008 Dec; 217(3):674-85.
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Kenny HA, Krausz T, Yamada SD, Lengyel E. Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum. Int J Cancer. 2007 Oct 01; 121(7):1463-72.
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Guzy RD, Schumacker PT. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol. 2006 Sep; 91(5):807-19.
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McCaffrey TA, Pomerantz KB, Sanborn TA, Spokojny AM, Du B, Park MH, Folk JE, Lamberg A, Kivirikko KI, Falcone DJ, et al. Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries. J Clin Invest. 1995 Feb; 95(2):446-55.
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