 Mutation
"Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
| Descriptor ID |
D009154
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| MeSH Number(s) |
G05.365.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mutation".
Below are MeSH descriptors whose meaning is more specific than "Mutation".
This graph shows the total number of publications written about "Mutation" by people in this website by year, and whether "Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 1 | 5 | 6 | | 1981 | 0 | 4 | 4 | | 1982 | 0 | 6 | 6 | | 1983 | 2 | 7 | 9 | | 1984 | 3 | 12 | 15 | | 1985 | 5 | 13 | 18 | | 1986 | 3 | 16 | 19 | | 1987 | 6 | 10 | 16 | | 1988 | 4 | 11 | 15 | | 1989 | 13 | 13 | 26 | | 1990 | 10 | 19 | 29 | | 1991 | 10 | 9 | 19 | | 1992 | 12 | 24 | 36 | | 1993 | 8 | 17 | 25 | | 1994 | 12 | 33 | 45 | | 1995 | 16 | 28 | 44 | | 1996 | 24 | 23 | 47 | | 1997 | 26 | 18 | 44 | | 1998 | 23 | 38 | 61 | | 1999 | 14 | 35 | 49 | | 2000 | 27 | 41 | 68 | | 2001 | 15 | 48 | 63 | | 2002 | 21 | 50 | 71 | | 2003 | 20 | 78 | 98 | | 2004 | 19 | 58 | 77 | | 2005 | 22 | 79 | 101 | | 2006 | 25 | 71 | 96 | | 2007 | 27 | 55 | 82 | | 2008 | 25 | 64 | 89 | | 2009 | 25 | 66 | 91 | | 2010 | 33 | 65 | 98 | | 2011 | 36 | 82 | 118 | | 2012 | 43 | 70 | 113 | | 2013 | 41 | 69 | 110 | | 2014 | 42 | 76 | 118 | | 2015 | 45 | 88 | 133 | | 2016 | 40 | 90 | 130 | | 2017 | 30 | 71 | 101 | | 2018 | 39 | 100 | 139 | | 2019 | 45 | 63 | 108 | | 2020 | 24 | 84 | 108 | | 2021 | 22 | 78 | 100 | | 2022 | 5 | 41 | 46 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mutation" by people in Profiles.
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de Botton S, Montesinos P, Schuh AC, Papayannidis C, Vyas P, Wei AH, Ommen H, Semochkin S, Kim HJ, Larson RA, Koprivnikar J, Frankfurt O, Thol F, Chromik J, Byrne J, Pigneux A, Thomas X, Salamero O, Vidriales MB, Doronin V, Döhner H, Fathi AT, Laille E, Yu X, Hasan M, Martin-Regueira P, DiNardo CD. Enasidenib vs conventional care in older patients with late-stage mutant-IDH2 relapsed/refractory AML: a randomized phase 3 trial. Blood. 2023 Jan 12; 141(2):156-167.
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Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022 09 22; 140(12):1345-1377.
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Perea-Gil I, Seeger T, Bruyneel AAN, Termglinchan V, Monte E, Lim EW, Vadgama N, Furihata T, Gavidia AA, Arthur Ataam J, Bharucha N, Martinez-Amador N, Ameen M, Nair P, Serrano R, Kaur B, Feyen DAM, Diecke S, Snyder MP, Metallo CM, Mercola M, Karakikes I. Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. Eur Heart J. 2022 09 21; 43(36):3477-3489.
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Jutzi JS, Marneth AE, Ciboddo M, Guerra-Moreno A, Jiménez-Santos MJ, Kosmidou A, Dressman JW, Liang H, Hamel R, Lozano P, Rumi E, Doench JG, Gotlib J, Krishnan A, Elf S, Al-Shahrour F, Mullally A. Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs. Blood. 2022 09 15; 140(11):1291-1304.
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Di Donato N, Guerrini R, Billington CJ, Barkovich AJ, Dinkel P, Freri E, Heide M, Gershon ES, Gertler TS, Hopkin RJ, Jacob S, Keedy SK, Kooshavar D, Lockhart PJ, Lohmann DR, Mahmoud IG, Parrini E, Schrock E, Severi G, Timms AE, Webster RI, Willis MJH, Zaki MS, Gleeson JG, Leventer RJ, Dobyns WB. Monoallelic and biallelic mutations in RELN underlie a graded series of neurodevelopmental disorders. Brain. 2022 09 14; 145(9):3274-3287.
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Milligan WR, Amster G, Sella G. The impact of genetic modifiers on variation in germline mutation rates within and among human populations. Genetics. 2022 07 30; 221(4).
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França MM, Reeve L, Dumitrescu AM, de Bock M, Refetoff S. A Novel Pathogenic Variant in PAX8 Leads to Familial Congenital Hypothyroidism. Thyroid. 2022 08; 32(8):1000-1002.
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Ibarra J, Elbanna YA, Kurylowicz K, Ciboddo M, Greenbaum HS, Arellano NS, Rodriguez D, Evers M, Bock-Hughes A, Liu C, Smith Q, Lutze J, Baumeister J, Kalmer M, Olschok K, Nicholson B, Silva D, Maxwell L, Dowgielewicz J, Rumi E, Pietra D, Casetti IC, Catricala S, Koschmieder S, Gurbuxani S, Schneider RK, Oakes SA, Elf SE. Type I but Not Type II Calreticulin Mutations Activate the IRE1a/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms. Blood Cancer Discov. 2022 07 06; 3(4):298-315.
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Kurnit KC, Fellman BM, Mills GB, Bowser JL, Xie S, Broaddus RR. Adjuvant treatment in early-stage endometrial cancer: context-dependent impact of somatic CTNNB1 mutation on recurrence-free survival. Int J Gynecol Cancer. 2022 07 04; 32(7):869-874.
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Konopleva M, Thirman MJ, Pratz KW, Garcia JS, Recher C, Pullarkat V, Kantarjian HM, DiNardo CD, Dail M, Duan Y, Chyla B, Potluri J, Miller CL, Wei AH. Impact of FLT3 Mutation on Outcomes after Venetoclax and Azacitidine for Patients with Treatment-Naïve Acute Myeloid Leukemia. Clin Cancer Res. 2022 07 01; 28(13):2744-2752.
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