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Ayodeji Adegunsoye

AddressChicago IL 60637
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    I am a pulmonary & critical care physician-scientist whose interests focus on the intersection between clinical risk-prediction models and genomic markers to improve pulmonary fibrosis outcomes.

    Pulmonary fibrosis is a destructive interstitial lung disease characterized by profound scarring. In severe pulmonary fibrosis, death generally ensues within three to five years. Recent genomic advances have identified factors that influence heterogeneity and prognosis in pulmonary fibrosis. However, healthcare disparities and the exclusion of major racial groups from these genetic studies limits the generalizability of their findings. My work leverages advanced statistical techniques to improve the delivery of high-quality care in patients with fibrotic lung diseases. Much of my research is aimed at identifying improved practical strategies to optimize pharmacotherapy in patients with pulmonary fibrosis.

    The main thrust of my work is currently on utilizing genetic data from diverse races to improve clinical decision-making and outcomes for all patients with pulmonary fibrosis.


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    K23HL146942     (ADEGUNSOYE, AYODEJI)Apr 1, 2020 - Mar 31, 2025
    NIH
    Improving Pulmonary Fibrosis Classification with Genomics Informed Phenotypic Clusters
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Adegunsoye A, Morisset J, Newton CA, Oldham JM, Vittinghoff E, Linderholm AL, Strek ME, Noth I, Garcia CK, Wolters PJ, Ley B. Leukocyte Telomere Length and Mycophenolate Therapy in Chronic Hypersensitivity Pneumonitis. Eur Respir J. 2020 Oct 29. PMID: 33122338.
      View in: PubMed
    2. Feurstein S, Adegunsoye A, Mojsilovic D, Vij R, West DePersia AH, Rajagopal PS, Osman A, Collins RH, Kim RH, Gore SD, Greenberg P, Godley LA, Li Z, Del Gaudio D, Subramanian HP, Das S, Walsh T, Gulsuner S, Segal JP, Husain AN, Gurbuxani S, King MC, Strek ME, Churpek JE. Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations. Blood Adv. 2020 Oct 13; 4(19):4873-4886. PMID: 33035329.
      View in: PubMed
    3. Adegunsoye A, Ventura IB, Liarski VM. Association of Black Race with Outcomes in COVID-19 Disease: A Retrospective Cohort Study. Ann Am Thorac Soc. 2020 10; 17(10):1336-1339. PMID: 32643398.
      View in: PubMed
    4. Graham J, Bauer Ventura I, Newton CA, Lee C, Boctor N, Pugashetti JV, Cutting C, Joerns E, Sandhu H, Chung JH, Garcia CK, Kadoch M, Noth I, Adegunsoye A, Strek ME, Oldham JM. Myositis-specific Antibodies Identify A Distinct Interstitial Pneumonia with Autoimmune Features Phenotype. Eur Respir J. 2020 Jul 16. PMID: 32675203.
      View in: PubMed
    5. Adegunsoye A, Neborak JM, Zhu D, Cantrill B, Garcia N, Oldham JM, Noth I, Vij R, Kuzniar TJ, Bellam SK, Strek ME, Mokhlesi B. CPAP Adherence, Mortality, and Progression-Free Survival in Interstitial Lung Disease and OSA. Chest. 2020 Oct; 158(4):1701-1712. PMID: 32450237.
      View in: PubMed
    6. Adegunsoye A, Alqalyoobi S, Linderholm A, Bowman WS, Lee CT, Pugashetti JV, Sarma N, Ma SF, Haczku A, Sperling A, Strek ME, Noth I, Oldham JM. Circulating Plasma Biomarkers of Survival in Antifibrotic-Treated Patients With Idiopathic Pulmonary Fibrosis. Chest. 2020 Oct; 158(4):1526-1534. PMID: 32450241.
      View in: PubMed
    7. Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 03 01; 201(5):564-574. PMID: 31710517.
      View in: PubMed
    8. Alqalyoobi S, Adegunsoye A, Linderholm A, Hrusch C, Cutting C, Ma SF, Sperling A, Noth I, Strek ME, Oldham JM. Circulating Plasma Biomarkers of Progressive Interstitial Lung Disease. Am J Respir Crit Care Med. 2020 01 15; 201(2):250-253. PMID: 31524503.
      View in: PubMed
    9. Pritchard D, Adegunsoye A, Lafond E, Pugashetti JV, DiGeronimo R, Boctor N, Sarma N, Pan I, Strek M, Kadoch M, Chung JH, Oldham JM. Diagnostic test interpretation and referral delay in patients with interstitial lung disease. Respir Res. 2019 Nov 12; 20(1):253. PMID: 31718645.
      View in: PubMed
    10. Ley B, Torgerson DG, Oldham JM, Adegunsoye A, Liu S, Li J, Elicker BM, Henry TS, Golden JA, Jones KD, Dressen A, Yaspan BL, Arron JR, Noth I, Hoffmann TJ, Wolters PJ. Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis. Am J Respir Crit Care Med. 2019 11 01; 200(9):1154-1163. PMID: 31268371.
      View in: PubMed
    11. Adegunsoye A. MUC5B promoter variant: genomic fingerprint for early identification of undiagnosed pulmonary fibrosis. Thorax. 2019 12; 74(12):1111-1112. PMID: 31666387.
      View in: PubMed
    12. Liu GY, Ventura IB, Achtar-Zadeh N, Elicker BM, Jones KD, Wolters PJ, Collard HR, Adegunsoye A, Strek ME, Ley B. Prevalence and Clinical Significance of Antineutrophil Cytoplasmic Antibodies in North American Patients With Idiopathic Pulmonary Fibrosis. Chest. 2019 10; 156(4):715-723. PMID: 31181198.
      View in: PubMed
    13. Adegunsoye A, Oldham JM, Bellam SK, Montner S, Churpek MM, Noth I, Vij R, Strek ME, Chung JH. Computed Tomography Honeycombing Identifies a Progressive Fibrotic Phenotype with Increased Mortality across Diverse Interstitial Lung Diseases. Ann Am Thorac Soc. 2019 05; 16(5):580-588. PMID: 30653927.
      View in: PubMed
    14. Adegunsoye A, Oldham JM, Sperling AI, Noth I, Strek ME, Chung JH. Reply to Lescoat et al. and to Khamis et al. Am J Respir Crit Care Med. 2019 04 15; 199(8):1041-1042. PMID: 30653922.
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    15. Newton CA, Oldham JM, Ley B, Anand V, Adegunsoye A, Liu G, Batra K, Torrealba J, Kozlitina J, Glazer C, Strek ME, Wolters PJ, Noth I, Garcia CK. Telomere length and genetic variant associations with interstitial lung disease progression and survival. Eur Respir J. 2019 04; 53(4). PMID: 30635297.
      View in: PubMed
    16. Adegunsoye A, Oldham JM, Bonham C, Hrusch C, Nolan P, Klejch W, Bellam S, Mehta U, Thakrar K, Pugashetti JV, Husain AN, Montner SM, Straus CM, Vij R, Sperling AI, Noth I, Strek ME, Chung JH. Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment. An Observational Cohort Study with Independent Validation. Am J Respir Crit Care Med. 2019 03 15; 199(6):747-759. PMID: 30216085.
      View in: PubMed
    17. Adegunsoye A. Diagnostic Delay in Idiopathic Pulmonary Fibrosis: Where the Rubber Meets the Road. Ann Am Thorac Soc. 2019 03; 16(3):310-312. PMID: 30821491.
      View in: PubMed
    18. Adegunsoye A, Vij R, Noth I. Integrating Genomics Into Management of Fibrotic Interstitial Lung Disease. Chest. 2019 05; 155(5):1026-1040. PMID: 30660786.
      View in: PubMed
    19. Bermea RS, Adegunsoye A, Oldham J, Ventura I, Lee C, Chung JH, Montner S, Noth I, Strek ME, Vij R. Anti-RNA binding protein positivity in idiopathic interstitial pneumonia. Respir Med. 2019 01; 146:23-27. PMID: 30665514.
      View in: PubMed
    20. Adegunsoye A, Oldham JM, Bellam SK, Chung JH, Chung PA, Biblowitz KM, Montner S, Lee C, Hsu S, Husain AN, Vij R, Mutlu G, Noth I, Churpek MM, Strek ME. African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis. Eur Respir J. 2018 06; 51(6). PMID: 29724923.
      View in: PubMed
    21. Oldham JM, Adegunsoye A, Khera S, Lafond E, Noth I, Strek ME, Kadoch M, Chung JH. Underreporting of Interstitial Lung Abnormalities on Lung Cancer Screening Computed Tomography. Ann Am Thorac Soc. 2018 06; 15(6):764-766. PMID: 29490147.
      View in: PubMed
    22. Chung JH, Oldham JM, Montner SM, Vij R, Adegunsoye A, Husain AN, Noth I, Lynch DA, Strek ME. CT-Pathologic Correlation of Major Types of Pulmonary Fibrosis: Insights for Revisions to Current Guidelines. AJR Am J Roentgenol. 2018 May; 210(5):1034-1041. PMID: 29547052.
      View in: PubMed
    23. Oldham JM, Witt LJ, Adegunsoye A, Chung JH, Lee C, Hsu S, Chen LW, Husain A, Montner S, Vij R, Strek ME, Noth I. N-acetylcysteine exposure is associated with improved survival in anti-nuclear antibody seropositive patients with usual interstitial pneumonia. BMC Pulm Med. 2018 Feb 08; 18(1):30. PMID: 29422061.
      View in: PubMed
    24. Chung JH, Cox CW, Montner SM, Adegunsoye A, Oldham JM, Husain AN, Vij R, Noth I, Lynch DA, Strek ME. CT Features of the Usual Interstitial Pneumonia Pattern: Differentiating Connective Tissue Disease-Associated Interstitial Lung Disease From Idiopathic Pulmonary Fibrosis. AJR Am J Roentgenol. 2018 Feb; 210(2):307-313. PMID: 29140119.
      View in: PubMed
    25. Adegunsoye A, Oldham JM, Husain AN, Chen L, Hsu S, Montner S, Chung JH, Vij R, Noth I, Strek ME. Autoimmune Hypothyroidism As a Predictor of Mortality in Chronic Hypersensitivity Pneumonitis. Front Med (Lausanne). 2017; 4:170. PMID: 29085824.
      View in: PubMed
    26. Adegunsoye A, Oldham JM, Chung JH, Montner SM, Lee C, Witt LJ, Stahlbaum D, Bermea RS, Chen LW, Hsu S, Husain AN, Noth I, Vij R, Strek ME, Churpek M. Phenotypic Clusters Predict Outcomes in a Longitudinal Interstitial Lung Disease Cohort. Chest. 2018 02; 153(2):349-360. PMID: 28964798.
      View in: PubMed
    27. Chen LW, McShane PJ, Karkowsky W, Gray SE, Adegunsoye A, Stock W, Artz A, White SR, Montner SM, Strek ME. De Novo Development of Bronchiectasis in Patients With Hematologic Malignancy. Chest. 2017 09; 152(3):683-685. PMID: 28889888.
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    28. Adegunsoye A, Oldham JM, Fernández Pérez ER, Hamblin M, Patel N, Tener M, Bhanot D, Robinson L, Bullick S, Chen L, Hsu S, Churpek M, Hedeker D, Montner S, Chung JH, Husain AN, Noth I, Strek ME, Vij R. Outcomes of immunosuppressive therapy in chronic hypersensitivity pneumonitis. ERJ Open Res. 2017 Jul; 3(3). PMID: 28845429.
      View in: PubMed
    29. Chung JH, Montner SM, Adegunsoye A, Oldham JM, Husain AN, Vij R, Noth I, Strek ME. CT findings associated with survival in chronic hypersensitivity pneumonitis. Eur Radiol. 2017 Dec; 27(12):5127-5135. PMID: 28687910.
      View in: PubMed
    30. Hrusch CL, Manns ST, Bryazka D, Casaos J, Bonham CA, Jaffery MR, Blaine KM, Mills KAM, Verhoef PA, Adegunsoye AO, Williams JW, Tjota MY, Moore TV, Strek ME, Noth I, Sperling AI. ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol. 2018 01; 11(1):61-70. PMID: 28488693.
      View in: PubMed
    31. Adegunsoye A, Oldham JM, Valenzi E, Lee C, Witt LJ, Chen L, Montner S, Chung JH, Noth I, Vij R, Strek ME, Husain AN. Interstitial Pneumonia With Autoimmune Features: Value of Histopathology. Arch Pathol Lab Med. 2017 Jul; 141(7):960-969. PMID: 28467213.
      View in: PubMed
    32. Chung JH, Montner SM, Adegunsoye A, Lee C, Oldham JM, Husain AN, MacMahon H, Noth I, Vij R, Strek ME. CT Findings, Radiologic-Pathologic Correlation, and Imaging Predictors of Survival for Patients With Interstitial Pneumonia With Autoimmune Features. AJR Am J Roentgenol. 2017 Jun; 208(6):1229-1236. PMID: 28350485.
      View in: PubMed
    33. Strek ME, Oldham JM, Adegunsoye A, Vij R. A call for uniformity in implementing the IPAF (interstitial pneumonia with autoimmune features) criteria. Eur Respir J. 2016 12; 48(6):1813-1814. PMID: 27903693.
      View in: PubMed
    34. Adegunsoye A, Hrusch CL, Bonham CA, Jaffery MR, Blaine KM, Sullivan M, Churpek MM, Strek ME, Noth I, Sperling AI. Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function. Front Immunol. 2016; 7:516. PMID: 27933058.
      View in: PubMed
    35. Oldham JM, Lee C, Valenzi E, Witt LJ, Adegunsoye A, Hsu S, Chen L, Montner S, Chung JH, Noth I, Vij R, Strek ME. Azathioprine response in patients with fibrotic connective tissue disease-associated interstitial lung disease. Respir Med. 2016 12; 121:117-122. PMID: 27888985.
      View in: PubMed
    36. Adegunsoye A, Strek ME, Garrity E, Guzy R, Bag R. Comprehensive Care of the Lung Transplant Patient. Chest. 2017 07; 152(1):150-164. PMID: 27729262.
      View in: PubMed
    37. Magee AL, Montner SM, Husain A, Adegunsoye A, Vij R, Chung JH. Imaging of Hypersensitivity Pneumonitis. Radiol Clin North Am. 2016 Nov; 54(6):1033-1046. PMID: 27719974.
      View in: PubMed
    38. Adegunsoye A, Strek ME. Therapeutic Approach to Adult Fibrotic Lung Diseases. Chest. 2016 Dec; 150(6):1371-1386. PMID: 27521738.
      View in: PubMed
    39. Oldham JM, Adegunsoye A, Valenzi E, Lee C, Witt L, Chen L, Husain AN, Montner S, Chung JH, Cottin V, Fischer A, Noth I, Vij R, Strek ME. Characterisation of patients with interstitial pneumonia with autoimmune features. Eur Respir J. 2016 06; 47(6):1767-75. PMID: 27103387.
      View in: PubMed
    40. Adegunsoye A, Oldham JM, Demchuk C, Montner S, Vij R, Strek ME. Predictors of survival in coexistent hypersensitivity pneumonitis with autoimmune features. Respir Med. 2016 05; 114:53-60. PMID: 27109811.
      View in: PubMed
    41. Adegunsoye A, Levy M, Oyenuga O. Novel Therapeutic Strategies for Reducing Right Heart Failure Associated Mortality in Fibrotic Lung Diseases. Biomed Res Int. 2015; 2015:929170. PMID: 26583148.
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    42. Adegunsoye A, Balachandran J. Inflammatory response mechanisms exacerbating hypoxemia in coexistent pulmonary fibrosis and sleep apnea. Mediators Inflamm. 2015; 2015:510105. PMID: 25944985.
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    43. Adegunsoye A, Ramachandran S. Etiopathogenetic mechanisms of pulmonary hypertension in sleep-related breathing disorders. Pulm Med. 2012; 2012:273591. PMID: 22848814.
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    44. Adegunsoye AO, Matchett S, Valentino DJ. A 20-year-old woman with rapidly progressive dyspnea and diffuse pulmonary infiltrates. Respir Med Case Rep. 2012; 5:34-6. PMID: 26058070.
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    45. Hage FG, Adegunsoye A, Mundkur M, Nanda NC. The role of echocardiography in the evaluation and management of aortic stenosis in the older adult. Int J Cardiol. 2012 Feb 23; 155(1):39-48. PMID: 21397347.
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    46. Adegunsoye A, Mundkur M, Nanda NC, Hage FG. Echocardiographic evaluation of calcific aortic stenosis in the older adult. Echocardiography. 2011 Jan; 28(1):117-29. PMID: 21198824.
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