Hypoxanthine Phosphoribosyltransferase
"Hypoxanthine Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
| Descriptor ID |
D007041
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| MeSH Number(s) |
D08.811.913.400.725.450
|
| Concept/Terms |
Hypoxanthine Phosphoribosyltransferase- Hypoxanthine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine
- IMP Pyrophosphorylase
- Pyrophosphorylase, IMP
- HGPRT
- HPRT
- HPRTase
- Hypoxanthine-Guanine Phosphoribosyltransferase
- Hypoxanthine Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine-Guanine
- Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Guanine
|
Below are MeSH descriptors whose meaning is more general than "Hypoxanthine Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Hypoxanthine Phosphoribosyltransferase".
This graph shows the total number of publications written about "Hypoxanthine Phosphoribosyltransferase" by people in this website by year, and whether "Hypoxanthine Phosphoribosyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hypoxanthine Phosphoribosyltransferase" by people in Profiles.
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Electron transport chain inhibition increases cellular dependence on purine transport and salvage. Cell Metab. 2024 Jul 02; 36(7):1504-1520.e9.
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TqPCR: A Touchdown qPCR Assay with Significantly Improved Detection Sensitivity and Amplification Efficiency of SYBR Green qPCR. PLoS One. 2015; 10(7):e0132666.
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Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting. PLoS One. 2013; 8(4):e61189.
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Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure. Mutagenesis. 2008 Sep; 23(5):341-6.
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Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells. Genes Cells. 2006 Apr; 11(4):363-71.
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Chemopreventive doses of amifostine confer no cytoprotection to tumor nodules growing in the lungs of mice treated with cyclophosphamide. Semin Oncol. 1999 Apr; 26(2 Suppl 7):22-7.
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The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065. Mutat Res. 1996 Sep 23; 356(2):147-54.
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Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis. 1995 Apr; 16(4):767-74.
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Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). Mutagenesis. 1994 Jul; 9(4):355-60.
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Induction of hprt mutations in mice after exposure to fission-spectrum neutrons or 60Co gamma rays. Radiat Res. 1993 Nov; 136(2):289-92.