"SRS-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
| Descriptor ID |
D013189
|
| MeSH Number(s) |
D10.251.355.255.100.450.855 D10.251.355.310.166.887.855 D23.469.050.175.450.725
|
| Concept/Terms |
SRS-A- SRS-A
- Slow Reacting Substance of Anaphylaxis
|
Below are MeSH descriptors whose meaning is more general than "SRS-A".
Below are MeSH descriptors whose meaning is more specific than "SRS-A".
This graph shows the total number of publications written about "SRS-A" by people in this website by year, and whether "SRS-A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
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Below are the most recent publications written about "SRS-A" by people in Profiles.
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Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. Chest. 2009 May; 135(5):1142-1149.
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Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2. J Clin Invest. 1993 May; 91(5):2118-25.
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Effect of aminophylline on the pulmonary and systemic hemodynamic response to group B beta-hemolytic Streptococcus and leukotriene D4 in newborn lambs. J Dev Physiol. 1992 Apr; 17(4):195-200.
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Hemodynamic effects of heat-killed group B beta-hemolytic streptococcus in newborn lambs: role of leukotriene D4. Pediatr Res. 1992 Feb; 31(2):121-6.
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Hemodynamic effects of oleic acid in newborn lambs: role of arachidonic acid metabolites. J Dev Physiol. 1991 Sep; 16(3):167-72.
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In vivo and in vitro effects of antihistamines on mast cell mediator release: a potentially important property in the treatment of allergic disease. Ann Allergy. 1989 Nov; 63(5):465-9.
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Leukotriene antagonists attenuate thromboxane-inducible pulmonary hypertension. Pediatr Res. 1989 Aug; 26(2):83-7.
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In vivo release of inflammatory mediators by hyperosmolar solutions. Am Rev Respir Dis. 1988 Mar; 137(3):606-12.
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Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. J Surg Res. 1988 Feb; 44(2):172-7.
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Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. Ann N Y Acad Sci. 1988; 524:103-21.