"Leukotriene C4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
| Descriptor ID |
D017997
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| MeSH Number(s) |
D10.251.355.255.100.450.855.455 D10.251.355.310.166.887.855.455 D23.469.050.175.450.725.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Leukotriene C4".
Below are MeSH descriptors whose meaning is more specific than "Leukotriene C4".
This graph shows the total number of publications written about "Leukotriene C4" by people in this website by year, and whether "Leukotriene C4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 0 | 2 |
| 2000 | 1 | 2 | 3 |
| 2001 | 0 | 2 | 2 |
| 2003 | 1 | 3 | 4 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leukotriene C4" by people in Profiles.
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Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. J Immunol. 2006 Jul 01; 177(1):574-82.
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Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. Life Sci. 2003 Oct 24; 73(23):3005-16.
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Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. J Immunol. 2003 Oct 15; 171(8):4399-405.
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Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. J Allergy Clin Immunol. 2003 Aug; 112(2):404-10.
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Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. J Biol Chem. 2003 Oct 03; 278(40):38813-20.
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Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). Am J Physiol Lung Cell Mol Physiol. 2001 Oct; 281(4):L844-51.
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Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils. J Immunol. 2001 Jul 01; 167(1):461-8.
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Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. Immunology. 2000 Jun; 100(2):231-7.
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Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2000 Jun; 278(6):L1172-9.
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CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. J Immunol. 2000 Mar 15; 164(6):3385-91.