 Synapses
"Synapses" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
| Descriptor ID |
D013569
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| MeSH Number(s) |
A08.850 A11.284.149.165.420.780
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synapses".
Below are MeSH descriptors whose meaning is more specific than "Synapses".
This graph shows the total number of publications written about "Synapses" by people in this website by year, and whether "Synapses" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1980 | 1 | 3 | 4 | | 1982 | 2 | 0 | 2 | | 1984 | 2 | 0 | 2 | | 1985 | 2 | 1 | 3 | | 1986 | 1 | 1 | 2 | | 1987 | 5 | 2 | 7 | | 1988 | 2 | 3 | 5 | | 1989 | 2 | 2 | 4 | | 1990 | 5 | 2 | 7 | | 1991 | 3 | 1 | 4 | | 1992 | 0 | 2 | 2 | | 1993 | 4 | 2 | 6 | | 1994 | 3 | 0 | 3 | | 1995 | 1 | 2 | 3 | | 1996 | 5 | 3 | 8 | | 1997 | 5 | 1 | 6 | | 1998 | 2 | 1 | 3 | | 1999 | 2 | 0 | 2 | | 2000 | 3 | 6 | 9 | | 2001 | 6 | 3 | 9 | | 2002 | 8 | 4 | 12 | | 2003 | 13 | 3 | 16 | | 2004 | 4 | 2 | 6 | | 2005 | 3 | 2 | 5 | | 2006 | 9 | 6 | 15 | | 2007 | 7 | 5 | 12 | | 2008 | 4 | 5 | 9 | | 2009 | 8 | 8 | 16 | | 2010 | 6 | 8 | 14 | | 2011 | 9 | 6 | 15 | | 2012 | 6 | 1 | 7 | | 2013 | 7 | 5 | 12 | | 2014 | 9 | 4 | 13 | | 2015 | 6 | 4 | 10 | | 2016 | 3 | 4 | 7 | | 2017 | 2 | 5 | 7 | | 2018 | 1 | 4 | 5 | | 2019 | 5 | 1 | 6 | | 2020 | 3 | 2 | 5 | | 2021 | 6 | 5 | 11 | | 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Synapses" by people in Profiles.
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Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Alonso MM, Wainwright DA, Gomez-Manzano C, Fueyo J. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer. 2022 Jul; 10(7).
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Wang Y, Lobb-Rabe M, Ashley J, Chatterjee P, Anand V, Bellen HJ, Kanca O, Carrillo RA. Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons. Development. 2022 May 15; 149(10).
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Kumaravelu K, Sombeck J, Miller LE, Bensmaia SJ, Grill WM. Stoney vs. Histed: Quantifying the spatial effects of intracortical microstimulation. Brain Stimul. 2022 Jan-Feb; 15(1):141-151.
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Kedia S, Mandal K, Netrakanti PR, Jose M, Sisodia SS, Nair D. Nanoscale organization of Nicastrin, the substrate receptor of the ?-secretase complex, as independent molecular domains. Mol Brain. 2021 10 13; 14(1):158.
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Wildenberg GA, Rosen MR, Lundell J, Paukner D, Freedman DJ, Kasthuri N. Primate neuronal connections are sparse in cortex as compared to mouse. Cell Rep. 2021 09 14; 36(11):109709.
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Sampathkumar V, Miller-Hansen A, Sherman SM, Kasthuri N. Integration of signals from different cortical areas in higher order thalamic neurons. Proc Natl Acad Sci U S A. 2021 07 27; 118(30).
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González-Garrido A, Pujol R, López-Ramírez O, Finkbeiner C, Eatock RA, Stone JS. The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse. J Neurosci. 2021 09 15; 41(37):7779-7796.
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Hansel C. Part II. J. C. Eccles, R. Llinas and K. Sasaki, The Excitatory Synaptic Action of Climbing Fibres on the Purkinje Cells of the Cerebellum, J Physiol, 182: 268-296, 1966: the Rise of the Complex Spike. Cerebellum. 2021 06; 20(3):330-339.
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Ofer N, Berger DR, Kasthuri N, Lichtman JW, Yuste R. Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies. Dev Neurobiol. 2021 07; 81(5):746-757.
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Kumar A, Basak S, Chakrapani S. Recombinant expression and purification of pentameric ligand-gated ion channels for Cryo-EM structural studies. Methods Enzymol. 2021; 652:81-103.
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