"Gap Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.
| Descriptor ID |
D017629
|
| MeSH Number(s) |
A11.284.149.165.420.471
|
| Concept/Terms |
Gap Junctions- Gap Junctions
- Gap Junction
- Junction, Gap
- Junctions, Gap
|
Below are MeSH descriptors whose meaning is more general than "Gap Junctions".
Below are MeSH descriptors whose meaning is more specific than "Gap Junctions".
This graph shows the total number of publications written about "Gap Junctions" by people in this website by year, and whether "Gap Junctions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 7 | 3 | 10 |
| 1995 | 11 | 0 | 11 |
| 1996 | 0 | 1 | 1 |
| 1997 | 3 | 1 | 4 |
| 1998 | 4 | 1 | 5 |
| 1999 | 2 | 1 | 3 |
| 2000 | 4 | 3 | 7 |
| 2001 | 3 | 1 | 4 |
| 2002 | 4 | 2 | 6 |
| 2003 | 3 | 0 | 3 |
| 2004 | 4 | 1 | 5 |
| 2005 | 0 | 1 | 1 |
| 2006 | 2 | 3 | 5 |
| 2007 | 0 | 2 | 2 |
| 2008 | 3 | 2 | 5 |
| 2009 | 3 | 3 | 6 |
| 2010 | 0 | 2 | 2 |
| 2011 | 4 | 2 | 6 |
| 2012 | 1 | 2 | 3 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 6 | 8 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 2 | 4 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 2 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gap Junctions" by people in Profiles.
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Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket. Biol Res. 2024 May 23; 57(1):31.
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Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice. Cells. 2022 09 07; 11(18).
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Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. J Biol Chem. 2022 03; 298(3):101673.
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The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells. Channels (Austin). 2021 Dec; 15(1):239-252.
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Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant. Biophys J. 2021 12 21; 120(24):5644-5656.
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Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome. Int J Mol Sci. 2020 Nov 24; 21(23).
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The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation. Invest Ophthalmol Vis Sci. 2019 05 01; 60(6):2336-2346.
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Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C492-C503.
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Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations. Islets. 2018; 10(4):151-167.
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Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):4366–4374.