 Thymidine Kinase
"Thymidine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
| Descriptor ID |
D013937
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| MeSH Number(s) |
D08.811.913.696.620.750
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| Concept/Terms |
Thymidine Kinase- Thymidine Kinase
- Kinase, Thymidine
- Deoxypyrimidine Kinase
- Kinase, Deoxypyrimidine
- Deoxythymidine Kinase
- Kinase, Deoxythymidine
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Below are MeSH descriptors whose meaning is more general than "Thymidine Kinase".
Below are MeSH descriptors whose meaning is more specific than "Thymidine Kinase".
This graph shows the total number of publications written about "Thymidine Kinase" by people in this website by year, and whether "Thymidine Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1993 | 0 | 2 | 2 | | 1995 | 1 | 1 | 2 | | 1997 | 2 | 0 | 2 | | 2000 | 2 | 2 | 4 | | 2003 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thymidine Kinase" by people in Profiles.
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Ross LF. Reflections on Charlie Gard and the Best Interests Standard From Both Sides of the Atlantic Ocean. Pediatrics. 2020 08; 146(Suppl 1):S60-S65.
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Gong J, Wang Z, Polejaeva I, Salgia R, Kao CM, Chen CT, Chen G, Chen L. Activating the expression of human K-rasG12D stimulates oncogenic transformation in transgenic goat fetal fibroblast cells. PLoS One. 2014; 9(3):e90059.
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Sjuvarsson E, Damaraju VL, Mowles D, Sawyer MB, Tiwari R, Agarwal HK, Khalil A, Hasabelnaby S, Goudah A, Nakkula RJ, Barth RF, Cass CE, Eriksson S, Tjarks W. Cellular influx, efflux, and anabolism of 3-carboranyl thymidine analogs: potential boron delivery agents for neutron capture therapy. J Pharmacol Exp Ther. 2013 Nov; 347(2):388-97.
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Westphal M, Ylä-Herttuala S, Martin J, Warnke P, Menei P, Eckland D, Kinley J, Kay R, Ram Z. Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial. Lancet Oncol. 2013 Aug; 14(9):823-33.
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Cheng F, Ke Q, Chen F, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li W, Xiang AP. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials. 2012 Apr; 33(11):3195-204.
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David S, Carmoy N, Resnier P, Denis C, Misery L, Pitard B, Benoit JP, Passirani C, Montier T. In vivo imaging of DNA lipid nanocapsules after systemic administration in a melanoma mouse model. Int J Pharm. 2012 Feb 14; 423(1):108-15.
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Hassan M, Zhang D, Salama S, Hamada F, Arafa H, Fouad H, Walker C, Al-Hendy A. Towards fibroid gene therapy: adenovirus-mediated delivery of herpes simplex virus 1 thymidine kinase gene/ganciclovir shrinks uterine leiomyoma in the Eker rat model. Gynecol Obstet Invest. 2009; 68(1):19-32.
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Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One. 2007 Oct 10; 2(10):e1007.
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Sanchez-Perez L, Gough M, Qiao J, Thanarajasingam U, Kottke T, Ahmed A, Thompson JM, Maria Diaz R, Vile RG. Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells. Gene Ther. 2007 Jul; 14(13):998-1009.
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Salama SA, Kamel M, Christman G, Wang HQ, Fouad HM, Al-Hendy A. Gene therapy of uterine leiomyoma: adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir treatment inhibits growth of human and rat leiomyoma cells in vitro and in a nude mouse model. Gynecol Obstet Invest. 2007; 63(2):61-70.
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