Motor Neuron Disease
"Motor Neuron Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Descriptor ID |
D016472
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MeSH Number(s) |
C10.574.562 C10.668.467
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Concept/Terms |
Motor Neuron Disease- Motor Neuron Disease
- Motor Neuron Diseases
- Neuron Disease, Motor
- Neuron Diseases, Motor
- Motor System Disease
- Motor System Diseases
Lateral Sclerosis- Lateral Sclerosis
- Lateral Scleroses
- Scleroses, Lateral
- Sclerosis, Lateral
- Primary Lateral Sclerosis
- Lateral Scleroses, Primary
- Lateral Sclerosis, Primary
- Primary Lateral Scleroses
- Scleroses, Primary Lateral
- Sclerosis, Primary Lateral
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Below are MeSH descriptors whose meaning is more general than "Motor Neuron Disease".
Below are MeSH descriptors whose meaning is more specific than "Motor Neuron Disease".
This graph shows the total number of publications written about "Motor Neuron Disease" by people in this website by year, and whether "Motor Neuron Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1992 | 1 | 1 | 2 | 1994 | 1 | 0 | 1 | 1995 | 1 | 0 | 1 | 1996 | 3 | 0 | 3 | 1997 | 2 | 0 | 2 | 1998 | 1 | 0 | 1 | 2000 | 0 | 1 | 1 | 2001 | 1 | 0 | 1 | 2007 | 1 | 0 | 1 | 2013 | 1 | 0 | 1 | 2020 | 1 | 0 | 1 | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Motor Neuron Disease" by people in Profiles.
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Bramble MS, Vashist N, Ko A, Priya S, Musasa C, Mathieu A, Spencer A, Lupamba Kasendue M, Mamona Dilufwasayo P, Karume K, Nsibu J, Manya H, Uy MNA, Colwell B, Boivin M, Mayambu JPB, Okitundu D, Droit A, Mumba Ngoyi D, Blekhman R, Tshala-Katumbay D, Vilain E. The gut microbiome in konzo. Nat Commun. 2021 09 10; 12(1):5371.
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de Carvalho M, Kiernan MC, Pullman SL, Rezania K, Turner MR, Simmons Z. Neurophysiological features of primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2020 11; 21(sup1):11-17.
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Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW. Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Sci Rep. 2016 Mar 18; 6:23326.
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Rezania K, Roos RP. Spinal cord: motor neuron diseases. Neurol Clin. 2013 Feb; 31(1):219-39.
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Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA. Characterization of two mutations, M287L and Q266I, in the a1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther. 2012 Feb; 340(2):304-16.
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Niemann S, Landers JE, Churchill MJ, Hosler B, Sapp P, Speed WC, Lahn BT, Kidd KK, Brown RH, Hayashi Y. Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele. Neurology. 2008 Feb 26; 70(9):666-76.
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Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci. 2007 Jun 27; 27(26):7011-20.
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Bromberg MB, Anderson F, Davidson M, Miller RG. Assessing health status quality of life in ALS: comparison of the SIP/ALS-19 with the ALS Functional Rating Scale and the Short Form-12 Health Survey. ALS C.A.R.E. Study Group. Clinical Assessement, Research, and Education. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 Mar; 2(1):31-7.
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Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR. The value of transgenic models for the study of neurodegenerative diseases. Ann N Y Acad Sci. 2000; 920:179-91.
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Hentati A, Ouahchi K, Pericak-Vance MA, Nijhawan D, Ahmad A, Yang Y, Rimmler J, Hung W, Schlotter B, Ahmed A, Ben Hamida M, Hentati F, Siddique T. Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. Neurogenetics. 1998 Dec; 2(1):55-60.
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