"Prion Diseases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)
| Descriptor ID |
D017096
|
| MeSH Number(s) |
C10.228.228.800 C10.574.843
|
| Concept/Terms |
Prion Diseases- Prion Diseases
- Spongiform Encephalopathies, Transmissible
- Encephalopathies, Transmissible Spongiform
- Encephalopathy, Transmissible Spongiform
- Spongiform Encephalopathy, Transmissible
- Transmissible Spongiform Encephalopathy
- Dementias, Transmissible
- Dementia, Transmissible
- Transmissible Dementia
- Transmissible Dementias
- Prion-Induced Disorders
- Prion Protein Diseases
- Prion Protein Disease
- Prion-Induced Disorder
- Disorder, Prion-Induced
- Disorders, Prion-Induced
- Prion Induced Disorder
- Prion Disease
- Prion-Associated Disorders
- Transmissible Spongiform Encephalopathies
- Encephalopathies, Spongiform, Transmissible
|
Below are MeSH descriptors whose meaning is more general than "Prion Diseases".
Below are MeSH descriptors whose meaning is more specific than "Prion Diseases".
This graph shows the total number of publications written about "Prion Diseases" by people in this website by year, and whether "Prion Diseases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 1 | 4 |
| 1996 | 2 | 0 | 2 |
| 1998 | 1 | 1 | 2 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 3 | 0 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2022 | 2 | 0 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Prion Diseases" by people in Profiles.
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Challenging Cases of Neurocognitive Disorders. Semin Neurol. 2022 12; 42(6):742-751.
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Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein. Int J Mol Sci. 2022 Nov 26; 23(23).
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Proposal of new diagnostic criteria for fatal familial insomnia. J Neurol. 2022 Sep; 269(9):4909-4919.
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Anle138b prevents PrP plaque accumulation in Tg(PrP-A116V) mice but does not mitigate clinical disease. J Gen Virol. 2019 06; 100(6):1027-1037.
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Preimplantation genetic diagnosis (PGD) for genetic prion disorder due to F198S mutation in the PRNP gene. JAMA Neurol. 2014 Apr; 71(4):484-6.
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Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Ann Neurol. 2011 Apr; 69(4):712-20.
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The prion diseases. J Geriatr Psychiatry Neurol. 2010 Dec; 23(4):277-98.
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Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein. Ann Neurol. 2010 Aug; 68(2):162-72.
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A novel human disease with abnormal prion protein sensitive to protease. Ann Neurol. 2008 Jun; 63(6):697-708.
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Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci. 2007 Nov 21; 27(47):13022-7.