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Engin Ozkan

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentBiochem/Mol Bio
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Cell surface receptor proteins and secreted protein ligands determine the specific connectivity of cells which drives the development of complex systems and organs in multicellular organisms. My laboratory is interested in the biochemistry, signaling activity and interaction networks of proteins that are required for the development and function of nervous systems. Specifically, we are working on deciphering protein-protein interaction networks of the extracellular space required for axon guidance and pruning and synapse formation and validation using high-throughout methods. We study these proteins using a multi-disciplinary approach, including crystallography, cellular signaling assays and protein engineering strategies coupled to genetic modifications in model organisms.


    Collapse Biography 
    Collapse education and training
    Bilkent University, Ankara, TurkeyB.S.06/1999Molecular Biology & Genetics
    U. of Texas Southwestern Med Ctr, Dallas, TXPh.D.05/2006Molecular Biophysics
    Stanford University, Stanford, CAPostdoctoral06/2013Biochemistry
    Collapse awards and honors
    2016Alfred P. Sloan Research Fellow in Neuroscience
    2015Klingenstein-Simons Neuroscience Fellow

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Cheng S, Park Y, Kurleto JD, Jeon M, Zinn K, Thornton JW, Özkan E. Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence. Proc Natl Acad Sci U S A. 2019 May 14; 116(20):9837-9842. PMID: 31043568.
      View in: PubMed
    2. Ranaivoson FM, Turk LS, Ozgul S, Kakehi S, von Daake S, Lopez N, Trobiani L, De Jaco A, Denissova N, Demeler B, Özkan E, Montelione GT, Comoletti D. A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals IgLONs as Structurally Conserved Interaction Modules at the Synapse. Structure. 2019 Mar 23. PMID: 30956130.
      View in: PubMed
    3. Stedden CG, Menegas W, Zajac AL, Williams AM, Cheng S, Özkan E, Horne-Badovinac S. Planar-Polarized Semaphorin-5c and Plexin A Promote the Collective Migration of Epithelial Cells in Drosophila. Curr Biol. 2019 Mar 18; 29(6):908-920.e6. PMID: 30827914.
      View in: PubMed
    4. Cheng S, Ashley J, Kurleto JD, Lobb-Rabe M, Park YJ, Carrillo RA, Özkan E. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Elife. 2019 Jan 28; 8. PMID: 30688651.
      View in: PubMed
    5. Li H, Watson A, Olechwier A, Anaya M, Sorooshyari SK, Harnett DP, Lee HP, Vielmetter J, Fares MA, Garcia KC, Özkan E, Labrador JP, Zinn K. Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development. Elife. 2017 08 15; 6. PMID: 28829740.
      View in: PubMed
    6. Zinn K, Özkan E. Neural immunoglobulin superfamily interaction networks. Curr Opin Neurobiol. 2017 08; 45:99-105. PMID: 28558267.
      View in: PubMed
    7. Cheng S, Seven AB, Wang J, Skiniotis G, Özkan E. Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex. Structure. 2016 12 06; 24(12):2163-2173. PMID: 27926833.
      View in: PubMed
    8. Dong X, Chiu H, Park YJ, Zou W, Zou Y, Özkan E, Chang C, Shen K. Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. Elife. 2016 Mar 14; 5. PMID: 26974341.
      View in: PubMed
    9. Carrillo RA, Özkan E, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K. Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins. Cell. 2015 Dec 17; 163(7):1770-1782. PMID: 26687361.
      View in: PubMed
    10. Hara M, Özkan E, Sun H, Yu H, Luo X. Structure of an intermediate conformer of the spindle checkpoint protein Mad2. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):11252-7. PMID: 26305957.
      View in: PubMed
    11. Maro GS, Gao S, Olechwier AM, Hung WL, Liu M, Özkan E, Zhen M, Shen K. MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin. Neuron. 2015 Jun 17; 86(6):1420-32. PMID: 26028574.
      View in: PubMed
    12. Ho CC, Guo N, Sockolosky JT, Ring AM, Weiskopf K, Özkan E, Mori Y, Weissman IL, Garcia KC. "Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein a (SIRPa) antagonists that enhance antibody-dependent cellular phagocytosis. J Biol Chem. 2015 May 15; 290(20):12650-63. PMID: 25837251.
      View in: PubMed
    13. Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 2014 May 22; 157(5):1073-87. PMID: 24855945.
      View in: PubMed
    14. Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC. Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis. Cell. 2014 Jan 30; 156(3):482-94. PMID: 24485456.
      View in: PubMed
    15. Özkan E, Carrillo RA, Eastman CL, Weiszmann R, Waghray D, Johnson KG, Zinn K, Celniker SE, Garcia KC. An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell. 2013 Jul 03; 154(1):228-39. PMID: 23827685.
      View in: PubMed
    16. Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK, Ozkan E, Fernhoff NB, van de Rijn M, Weissman IL, Garcia KC. Engineered SIRPa variants as immunotherapeutic adjuvants to anticancer antibodies. Science. 2013 Jul 05; 341(6141):88-91. PMID: 23722425.
      View in: PubMed
    17. Yu XM, Gutman I, Mosca TJ, Iram T, Ozkan E, Garcia KC, Luo L, Schuldiner O. Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-ß signaling. Neuron. 2013 May 08; 78(3):456-68. PMID: 23664613.
      View in: PubMed
    18. Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol. 2012 Dec; 13(12):1187-95. PMID: 23104097.
      View in: PubMed
    19. Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC. Molecular and structural insight into proNGF engagement of p75NTR and sortilin. J Mol Biol. 2010 Mar 05; 396(4):967-84. PMID: 20036257.
      View in: PubMed
    20. Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 2009 Oct 16; 139(2):380-92. PMID: 19818485.
      View in: PubMed
    21. Araç D, Boucard AA, Ozkan E, Strop P, Newell E, Südhof TC, Brunger AT. Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron. 2007 Dec 20; 56(6):992-1003. PMID: 18093522.
      View in: PubMed
    22. Ozkan E, Yu H, Deisenhofer J. Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18890-5. PMID: 16365295.
      View in: PubMed
    23. Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol Biol Cell. 2001 Dec; 12(12):3839-51. PMID: 11739784.
      View in: PubMed
    24. Usher KC, Ozkan E, Gardner KH, Deisenhofer J. The plug domain of FepA, a TonB-dependent transport protein from Escherichia coli, binds its siderophore in the absence of the transmembrane barrel domain. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10676-81. PMID: 11526207.
      View in: PubMed
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