"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 4 | 1 | 5 |
| 2001 | 3 | 1 | 4 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 4 | 2 | 6 |
| 2005 | 2 | 2 | 4 |
| 2006 | 1 | 2 | 3 |
| 2007 | 0 | 3 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 2 | 3 |
| 2011 | 7 | 2 | 9 |
| 2012 | 2 | 5 | 7 |
| 2013 | 2 | 3 | 5 |
| 2014 | 5 | 5 | 10 |
| 2015 | 8 | 7 | 15 |
| 2016 | 6 | 2 | 8 |
| 2017 | 6 | 7 | 13 |
| 2018 | 7 | 11 | 18 |
| 2019 | 16 | 9 | 25 |
| 2020 | 14 | 8 | 22 |
| 2021 | 12 | 7 | 19 |
| 2022 | 5 | 8 | 13 |
| 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
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Limited role of generation time changes in driving the evolution of the mutation spectrum in humans. Elife. 2023 02 13; 12.
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Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2. J Clin Oncol. 2023 Mar 20; 41(9):1703-1713.
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Germ line predisposition variants occur in?myelodysplastic syndrome patients of all ages. Blood. 2022 12 15; 140(24):2533-2548.
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Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms. Br J Haematol. 2023 02; 200(4):489-493.
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Significance of hereditary gene alterations for the pathogenesis of adult bone marrow failure versus myeloid neoplasia. Leukemia. 2022 12; 36(12):2827-2834.
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Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis. Am J Gastroenterol. 2022 11 01; 117(11):1877-1879.
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Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations. Blood Adv. 2022 08 09; 6(15):4357-4359.
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A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers. Elife. 2022 08 02; 11.
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The impact of genetic modifiers on variation in germline mutation rates within and among human populations. Genetics. 2022 07 30; 221(4).
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Pancreatic Ductal Carcinoma Risk Associated With Hereditary Cancer-Risk Genes. J Natl Cancer Inst. 2022 07 11; 114(7):996-1002.