"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 4 | 1 | 5 |
| 2001 | 3 | 1 | 4 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 4 | 2 | 6 |
| 2005 | 2 | 2 | 4 |
| 2006 | 1 | 3 | 4 |
| 2007 | 0 | 3 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 2 | 3 |
| 2011 | 7 | 2 | 9 |
| 2012 | 2 | 5 | 7 |
| 2013 | 2 | 3 | 5 |
| 2014 | 5 | 5 | 10 |
| 2015 | 8 | 7 | 15 |
| 2016 | 6 | 2 | 8 |
| 2017 | 6 | 7 | 13 |
| 2018 | 8 | 11 | 19 |
| 2019 | 17 | 9 | 26 |
| 2020 | 14 | 8 | 22 |
| 2021 | 12 | 10 | 22 |
| 2022 | 5 | 10 | 15 |
| 2023 | 1 | 11 | 12 |
| 2024 | 9 | 3 | 12 |
| 2025 | 5 | 4 | 9 |
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click here.
Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
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Prevalence of Pathogenic Germline Variants in Patients With Gastric Cancer Ascertained Through Multigene Panel Testing. JCO Precis Oncol. 2025 Jun; 9:e2400620.
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Estimating Cancer Penetrance in Carriers of BRCA2 Pathogenic Variants Using Cancer-Specific Polygenic Scores. Cancer Med. 2025 Jun; 14(11):e70990.
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Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification. Nat Commun. 2025 May 25; 16(1):4852.
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Update on Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome. Clin Cancer Res. 2025 May 15; 31(10):1831-1840.
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Germline mutation rates and fine-scale recombination parameters in zebra finch. PLoS Genet. 2025 Apr; 21(4):e1011661.
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PKCd Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells. Cancer Immunol Res. 2025 Apr 02; 13(4):547-559.
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Advancing the Evaluation and Management of CDH1-Associated Gastric Cancer. J Natl Compr Canc Netw. 2025 04; 23(4).
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Germline and Somatic Genomic Testing for Metastatic Prostate Cancer: ASCO Guideline. J Clin Oncol. 2025 Feb 20; 43(6):748-758.
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Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma In Situ of the Breast. Clin Cancer Res. 2025 Jan 06; 31(1):130-138.
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Diagnostic Challenges due to a Germline Missense MSH2 Variant in a Patient With Immunotherapy-Responsive Locally Advanced Rectal Adenocarcinoma. Cancer Rep (Hoboken). 2024 Dec; 7(12):e70037.