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Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
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Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody. J Immunol. 1992 Jun 01; 148(11):3461-8.
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PubMed
subject areas
Amino Acid Sequence
Animals
Antibody Affinity
Antigens, Differentiation
Antigens, Differentiation, T-Lymphocyte
Binding Sites, Antibody
CD3 Complex
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
In Vitro Techniques
Interferon-gamma
Lymphocyte Activation
Mice
Molecular Sequence Data
Muromonab-CD3
Receptors, Antigen, T-Cell
Receptors, Fc
Receptors, IgG
Recombinant Fusion Proteins
T-Lymphocytes, Cytotoxic
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha
authors with profiles
Maria-Luisa Alegre
J. Richard Thistlethwaite