Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Alegre ML, Collins AM, Pulito VL, Brosius RA, Olson WC, Zivin RA, Knowles R, Thistlethwaite JR, Jolliffe LK, Bluestone JA. Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody. J Immunol. 1992 Jun 01; 148(11):3461-8.
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Amino Acid Sequence
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Animals
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Antibody Affinity
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Antigens, Differentiation
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Antigens, Differentiation, T-Lymphocyte
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Binding Sites, Antibody
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Granulocyte-Macrophage Colony-Stimulating Factor
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Humans
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Interferon-gamma
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Lymphocyte Activation
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Mice
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Molecular Sequence Data
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Muromonab-CD3
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Receptors, Antigen, T-Cell
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Receptors, Fc
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Receptors, IgG
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Recombinant Fusion Proteins
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T-Lymphocytes, Cytotoxic
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Tumor Cells, Cultured
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Tumor Necrosis Factor-alpha