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Tissue Inhibitor of Metalloproteinases

"Tissue Inhibitor of Metalloproteinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A family of secreted proteins (TIMP-1; TIMP-2; and TIMP-3) that play a crucial role in regulating the activity of the secreted METALLOENDOPEPTIDASES; (COLLAGENASES; stromelysins; GELATINASES). Of the three characterized, only TIMP-1 and TIMP-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)


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This graph shows the total number of publications written about "Tissue Inhibitor of Metalloproteinases" by people in this website by year, and whether "Tissue Inhibitor of Metalloproteinases" was a major or minor topic of these publications.
Bar chart showing 4 publications over 3 distinct years, with a maximum of 2 publications in 2006
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