Role of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors.

Role of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors. J Biol Chem. 2000 Nov 10; 275(45):35098-105.

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subject areas

Aggrecans
Animals
Biological Transport
Blotting, Western
Calcium
Carrier Proteins
Cell Line
Cells, Cultured
Chick Embryo
Chondroitin Sulfates
Chromatography, Affinity
COS Cells
Cysteine Endopeptidases
Cytosol
DNA, Complementary
Electrophoresis, Polyacrylamide Gel
Endoplasmic Reticulum
Exons
Extracellular Matrix Proteins
Galactose
Gene Deletion
Golgi Apparatus
Heat-Shock Proteins
Immunohistochemistry
Lectins
Lectins, C-Type
Molecular Chaperones
Multienzyme Complexes
Mutagenesis, Site-Directed
Phenotype
Plasmids
Precipitin Tests
Proteasome Endopeptidase Complex
Protein Binding
Protein Disulfide-Isomerases
Protein Folding
Protein Processing, Post-Translational
Protein Structure, Tertiary
Proteoglycans
Transfection
Translocation, Genetic
Ubiquitins

authors with profiles

Nancy B. Schwartz
Miriam Domowicz