 Ion Channel Gating
"Ion Channel Gating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
| Descriptor ID |
D015640
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| MeSH Number(s) |
G02.111.087.800.400 G02.149.115.800.400 G04.299.500 G04.299.880.400 G07.265.337.500 G07.700.240.500
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| Concept/Terms |
Ion Channel Gating- Ion Channel Gating
- Gating, Ion Channel
- Gatings, Ion Channel
- Ion Channel Gatings
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Below are MeSH descriptors whose meaning is more general than "Ion Channel Gating".
Below are MeSH descriptors whose meaning is more specific than "Ion Channel Gating".
This graph shows the total number of publications written about "Ion Channel Gating" by people in this website by year, and whether "Ion Channel Gating" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 3 | 1 | 4 | | 1991 | 2 | 0 | 2 | | 1992 | 2 | 1 | 3 | | 1993 | 2 | 1 | 3 | | 1994 | 8 | 4 | 12 | | 1995 | 2 | 6 | 8 | | 1996 | 3 | 9 | 12 | | 1997 | 2 | 3 | 5 | | 1998 | 8 | 3 | 11 | | 1999 | 4 | 7 | 11 | | 2000 | 4 | 3 | 7 | | 2001 | 4 | 2 | 6 | | 2002 | 6 | 7 | 13 | | 2003 | 2 | 2 | 4 | | 2004 | 8 | 5 | 13 | | 2005 | 11 | 2 | 13 | | 2006 | 12 | 11 | 23 | | 2007 | 8 | 2 | 10 | | 2008 | 8 | 6 | 14 | | 2009 | 4 | 3 | 7 | | 2010 | 10 | 5 | 15 | | 2011 | 10 | 2 | 12 | | 2012 | 10 | 1 | 11 | | 2013 | 10 | 2 | 12 | | 2014 | 5 | 1 | 6 | | 2015 | 5 | 2 | 7 | | 2016 | 0 | 5 | 5 | | 2017 | 1 | 3 | 4 | | 2018 | 8 | 3 | 11 |
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Below are the most recent publications written about "Ion Channel Gating" by people in Profiles.
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Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S. Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor. Nature. 2018 11; 563(7730):270-274.
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Gicheru Y, Chakrapani S. Direct visualization of ion-channel gating in a native environment. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10198-10200.
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Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9095-E9104.
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Bezanilla F. Gating currents. J Gen Physiol. 2018 07 02; 150(7):911-932.
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Infield DT, Lee EEL, Galpin JD, Galles GD, Bezanilla F, Ahern CA. Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape. J Gen Physiol. 2018 07 02; 150(7):1017-1024.
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Lacroix JJ, Botello-Smith WM, Luo Y. Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1. Nat Commun. 2018 05 23; 9(1):2029.
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Labro AJ, Cortes DM, Tilegenova C, Cuello LG. Inverted allosteric coupling between activation and inactivation gates in K+ channels. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):5426-5431.
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Lau C, Hunter MJ, Stewart A, Perozo E, Vandenberg JI. Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy. J Physiol. 2018 04 01; 596(7):1107-1119.
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Delgado-Ramírez M, De Jesús-Pérez JJ, Aréchiga-Figueroa IA, Arreola J, Adney SK, Villalba-Galea CA, Logothetis DE, Rodríguez-Menchaca AA. Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate. Sci Rep. 2018 01 29; 8(1):1769.
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Carvalho-de-Souza JL, Bezanilla F. Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels. J Gen Physiol. 2018 02 05; 150(2):307-321.
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