 Ion Channel Gating
"Ion Channel Gating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
| Descriptor ID |
D015640
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| MeSH Number(s) |
G02.111.087.800.400 G02.149.115.800.400 G04.299.500 G04.299.880.400 G07.265.337.500 G07.700.240.500
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| Concept/Terms |
Ion Channel Gating- Ion Channel Gating
- Gating, Ion Channel
- Gatings, Ion Channel
- Ion Channel Gatings
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Below are MeSH descriptors whose meaning is more general than "Ion Channel Gating".
Below are MeSH descriptors whose meaning is more specific than "Ion Channel Gating".
This graph shows the total number of publications written about "Ion Channel Gating" by people in this website by year, and whether "Ion Channel Gating" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 3 | 1 | 4 | | 1991 | 2 | 0 | 2 | | 1992 | 2 | 1 | 3 | | 1993 | 2 | 1 | 3 | | 1994 | 8 | 4 | 12 | | 1995 | 2 | 6 | 8 | | 1996 | 3 | 9 | 12 | | 1997 | 2 | 3 | 5 | | 1998 | 8 | 3 | 11 | | 1999 | 4 | 7 | 11 | | 2000 | 4 | 3 | 7 | | 2001 | 4 | 3 | 7 | | 2002 | 6 | 7 | 13 | | 2003 | 2 | 2 | 4 | | 2004 | 8 | 5 | 13 | | 2005 | 11 | 2 | 13 | | 2006 | 12 | 11 | 23 | | 2007 | 8 | 2 | 10 | | 2008 | 8 | 6 | 14 | | 2009 | 4 | 3 | 7 | | 2010 | 10 | 5 | 15 | | 2011 | 10 | 2 | 12 | | 2012 | 10 | 1 | 11 | | 2013 | 10 | 2 | 12 | | 2014 | 5 | 1 | 6 | | 2015 | 5 | 2 | 7 | | 2016 | 0 | 5 | 5 | | 2017 | 1 | 3 | 4 | | 2018 | 9 | 3 | 12 | | 2019 | 2 | 0 | 2 | | 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Ion Channel Gating" by people in Profiles.
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Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S. Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nat Commun. 2020 07 27; 11(1):3752.
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Clark MD, Contreras GF, Shen R, Perozo E. Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1. Nature. 2020 07; 583(7814):145-149.
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Rangl M, Schmandt N, Perozo E, Scheuring S. Real time dynamics of Gating-Related conformational changes in CorA. Elife. 2019 11 27; 8.
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Carvalho-de-Souza JL, Bezanilla F. Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker. Nat Commun. 2019 08 08; 10(1):3584.
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Horng TL, Eisenberg RS, Liu C, Bezanilla F. Continuum Gating Current Models Computed with Consistent Interactions. Biophys J. 2019 01 22; 116(2):270-282.
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Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S. Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor. Nature. 2018 11; 563(7730):270-274.
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Gicheru Y, Chakrapani S. Direct visualization of ion-channel gating in a native environment. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10198-10200.
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Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9095-E9104.
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Bezanilla F. Gating currents. J Gen Physiol. 2018 07 02; 150(7):911-932.
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Infield DT, Lee EEL, Galpin JD, Galles GD, Bezanilla F, Ahern CA. Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape. J Gen Physiol. 2018 07 02; 150(7):1017-1024.
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