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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010 Dec 16; 468(7326):973-7.
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PubMed
subject areas
Base Sequence
Cell Line, Tumor
Drug Resistance, Neoplasm
Enzyme Activation
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Indoles
MAP Kinase Signaling System
Melanoma
Mitogen-Activated Protein Kinase Kinases
Mutation
Oligonucleotide Array Sequence Analysis
Protein Kinase Inhibitors
Proto-Oncogene Proteins B-raf
Receptor Protein-Tyrosine Kinases
Receptor, Platelet-Derived Growth Factor beta
Sulfonamides
Up-Regulation
authors with profiles
Thinle Chodon
Richard Koya