 Complement Factor H
"Complement Factor H" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
| Descriptor ID |
D017242
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| MeSH Number(s) |
D12.776.124.486.274.920.325.200 D12.776.124.790.223.200 D12.776.377.715.182.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Complement Factor H".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor H".
This graph shows the total number of publications written about "Complement Factor H" by people in this website by year, and whether "Complement Factor H" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2007 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Factor H" by people in Profiles.
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Jacob A, Phelps M, Fraher S, Lopez M, Chang A, Quigg RJ, Alexander JJ. Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis. J Immunol Res. 2022; 2022:1737419.
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Mahajan S, Jacob A, Kelkar A, Chang A, Mcskimming D, Neelamegham S, Quigg RJ, Alexander JJ. Local complement factor H protects kidney endothelial cell structure and function. Kidney Int. 2021 10; 100(4):824-836.
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Seldeen KL, Thiyagarajan R, Redae Y, Jacob A, Troen BR, Quigg RJ, Alexander JJ. Absence of complement factor H reduces physical performance in C57BL6 mice. Immunobiology. 2020 09; 225(5):152003.
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Zhang Y, Kremsdorf RA, Sperati CJ, Henriksen KJ, Mori M, Goodfellow RX, Pitcher GR, Benson CL, Borsa NG, Taylor RP, Nester CM, Smith RJH. Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome. Kidney Int. 2020 11; 98(5):1265-1274.
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Alexander JJ, Sankaran JS, Seldeen KL, Thiyagarajan R, Jacob A, Quigg RJ, Troen BR, Judex S. Absence of complement factor H alters bone architecture and dynamics. Immunobiology. 2018 12; 223(12):761-771.
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Li Y, Fung J, Lin F. Local Inhibition of Complement Improves Mesenchymal Stem Cell Viability and Function After Administration. Mol Ther. 2016 09; 24(9):1665-74.
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Li Y, Qiu W, Zhang L, Fung J, Lin F. Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage. Biomaterials. 2016 09; 102:209-19.
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Alexander JJ, Chaves LD, Chang A, Dighe S, Jacob A, Quigg RJ. Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. Cell Mol Immunol. 2016 09; 13(5):651-7.
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Alexander JJ, Chaves LD, Chang A, Jacob A, Ritchie M, Quigg RJ. CD11b is protective in complement-mediated immune complex glomerulonephritis. Kidney Int. 2015 May; 87(5):930-9.
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Naik A, Sharma S, Quigg RJ. Complement regulation in renal disease models. Semin Nephrol. 2013 Nov; 33(6):575-85.
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