Patch-Clamp Techniques
"Patch-Clamp Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Descriptor ID |
D018408
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MeSH Number(s) |
E05.242.800
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Concept/Terms |
Patch-Clamp Techniques- Patch-Clamp Techniques
- Patch Clamp Techniques
- Patch-Clamp Technique
- Technique, Patch-Clamp
- Techniques, Patch-Clamp
- Patch-Clamp Technics
- Patch Clamp Technics
- Patch-Clamp Technic
- Technic, Patch-Clamp
- Technics, Patch-Clamp
Whole-Cell Recording- Whole-Cell Recording
- Recording, Whole-Cell
- Recordings, Whole-Cell
- Whole Cell Recording
- Whole-Cell Recordings
Voltage-Clamp Techniques- Voltage-Clamp Techniques
- Technique, Voltage-Clamp
- Techniques, Voltage-Clamp
- Voltage Clamp Techniques
- Voltage-Clamp Technique
- Voltage-Clamp Technics
- Technic, Voltage-Clamp
- Technics, Voltage-Clamp
- Voltage Clamp Technics
- Voltage-Clamp Technic
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Below are MeSH descriptors whose meaning is more general than "Patch-Clamp Techniques".
Below are MeSH descriptors whose meaning is more specific than "Patch-Clamp Techniques".
This graph shows the total number of publications written about "Patch-Clamp Techniques" by people in this website by year, and whether "Patch-Clamp Techniques" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 | 1995 | 0 | 14 | 14 | 1996 | 0 | 17 | 17 | 1997 | 0 | 13 | 13 | 1998 | 0 | 15 | 15 | 1999 | 0 | 11 | 11 | 2000 | 0 | 19 | 19 | 2001 | 1 | 12 | 13 | 2002 | 1 | 21 | 22 | 2003 | 0 | 20 | 20 | 2004 | 3 | 15 | 18 | 2005 | 0 | 14 | 14 | 2006 | 1 | 26 | 27 | 2007 | 1 | 24 | 25 | 2008 | 0 | 19 | 19 | 2009 | 0 | 13 | 13 | 2010 | 0 | 18 | 18 | 2011 | 0 | 16 | 16 | 2012 | 1 | 4 | 5 | 2013 | 0 | 11 | 11 | 2014 | 0 | 12 | 12 | 2015 | 1 | 10 | 11 | 2016 | 0 | 9 | 9 | 2017 | 0 | 5 | 5 | 2018 | 1 | 6 | 7 | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Patch-Clamp Techniques" by people in Profiles.
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Huang X, Rangel M, Briggman KL, Wei W. Neural mechanisms of contextual modulation in the retinal direction selective circuit. Nat Commun. 2019 06 03; 10(1):2431.
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Corbin-Leftwich A, Small HE, Robinson HH, Villalba-Galea CA, Boland LM. A Xenopus oocyte model system to study action potentials. J Gen Physiol. 2018 11 05; 150(11):1583-1593.
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Bezanilla F. Gating currents. J Gen Physiol. 2018 07 02; 150(7):911-932.
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Lacroix JJ, Botello-Smith WM, Luo Y. Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1. Nat Commun. 2018 05 23; 9(1):2029.
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Fry AE, Fawcett KA, Zelnik N, Yuan H, Thompson BAN, Shemer-Meiri L, Cushion TD, Mugalaasi H, Sims D, Stoodley N, Chung SK, Rees MI, Patel CV, Brueton LA, Layet V, Giuliano F, Kerr MP, Banne E, Meiner V, Lerman-Sagie T, Helbig KL, Kofman LH, Knight KM, Chen W, Kannan V, Hu C, Kusumoto H, Zhang J, Swanger SA, Shaulsky GH, Mirzaa GM, Muir AM, Mefford HC, Dobyns WB, Mackenzie AB, Mullins JGL, Lemke JR, Bahi-Buisson N, Traynelis SF, Iago HF, Pilz DT. De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain. 2018 03 01; 141(3):698-712.
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Mathur C, Johnson KR, Tong BA, Miranda P, Srikumar D, Basilio D, Latorre R, Bezanilla F, Holmgren M. Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation. Sci Rep. 2018 02 02; 8(1):2207.
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Delgado-Ramírez M, De Jesús-Pérez JJ, Aréchiga-Figueroa IA, Arreola J, Adney SK, Villalba-Galea CA, Logothetis DE, Rodríguez-Menchaca AA. Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate. Sci Rep. 2018 01 29; 8(1):1769.
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Vierra NC, Dickerson MT, Philipson LH, Jacobson DA. Simultaneous Real-Time Measurement of the ß-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ß-Cell Function. Methods Mol Biol. 2018; 1684:73-84.
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Kubota T, Dang B, Carvalho-de-Souza JL, Correa AM, Bezanilla F. Nav channel binder containing a specific conjugation-site based on a low toxicity ß-scorpion toxin. Sci Rep. 2017 11 27; 7(1):16329.
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Cuello LG, Cortes DM, Perozo E. The gating cycle of a K+ channel at atomic resolution. Elife. 2017 11 22; 6.
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