 Potassium Channel Blockers
"Potassium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
| Descriptor ID |
D026902
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| MeSH Number(s) |
D27.505.519.562.500 D27.505.954.411.645
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Potassium Channel Blockers".
Below are MeSH descriptors whose meaning is more specific than "Potassium Channel Blockers".
This graph shows the total number of publications written about "Potassium Channel Blockers" by people in this website by year, and whether "Potassium Channel Blockers" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 1 | 3 | | 1996 | 1 | 5 | 6 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 1 | 2 | | 2000 | 3 | 4 | 7 | | 2001 | 0 | 4 | 4 | | 2002 | 1 | 2 | 3 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 1 | 2 | | 2006 | 2 | 1 | 3 | | 2008 | 1 | 1 | 2 | | 2009 | 3 | 1 | 4 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2017 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Potassium Channel Blockers" by people in Profiles.
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Coonen L, Mayeur E, De Neuter N, Snyders DJ, Cuello LG, Labro AJ. The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. Biophys J. 2020 05 19; 118(10):2612-2620.
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Vandenberg JI, Perozo E, Allen TW. Towards a Structural View of Drug Binding to hERG K+ Channels. Trends Pharmacol Sci. 2017 10; 38(10):899-907.
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Hassiki R, Labro AJ, Benlasfar Z, Vincke C, Somia M, El Ayeb M, Muyldermans S, Snyders DJ, Bouhaouala-Zahar B. Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach. Int J Biol Macromol. 2016 Dec; 93(Pt A):167-171.
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Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ. Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. 2016 08; 107:160-167.
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MartÃnez-Morales E, Kopljar I, Snyders DJ, Labro AJ. Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening. Sci Rep. 2015 Nov 30; 5:17402.
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Garcia AJ, Rotem-Kohavi N, Doi A, Ramirez JM. Post-hypoxic recovery of respiratory rhythm generation is gender dependent. PLoS One. 2013; 8(4):e60695.
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Dwyer J, Lee H, Martell A, van Drongelen W. Resonance in neocortical neurons and networks. Eur J Neurosci. 2012 Dec; 36(12):3698-708.
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Robertson JL, Palmer LG, Roux B. Multi-ion distributions in the cytoplasmic domain of inward rectifier potassium channels. Biophys J. 2012 Aug 08; 103(3):434-443.
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Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA. A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22211-6.
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Jo SH, Hong HK, Chong SH, Lee HS, Choe H. H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. Pharmacol Res. 2009 Nov; 60(5):429-37.
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