Potassium Channel Blockers
"Potassium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
| Descriptor ID |
D026902
|
| MeSH Number(s) |
D27.505.519.562.500 D27.505.954.411.645
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Potassium Channel Blockers".
Below are MeSH descriptors whose meaning is more specific than "Potassium Channel Blockers".
This graph shows the total number of publications written about "Potassium Channel Blockers" by people in this website by year, and whether "Potassium Channel Blockers" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 1996 | 1 | 5 | 6 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 2 | 3 |
| 2000 | 3 | 4 | 7 |
| 2001 | 1 | 4 | 5 |
| 2002 | 1 | 3 | 4 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 2 | 2 | 4 |
| 2008 | 1 | 0 | 1 |
| 2009 | 3 | 2 | 5 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 1 | 4 |
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Potassium Channel Blockers" by people in Profiles.
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The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. Biophys J. 2020 05 19; 118(10):2612-2620.
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Towards a Structural View of Drug Binding to hERG K+ Channels. Trends Pharmacol Sci. 2017 10; 38(10):899-907.
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Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore. Toxicon. 2016 Sep 15; 120:57-60.
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Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach. Int J Biol Macromol. 2016 Dec; 93(Pt A):167-171.
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Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells. Cell Rep. 2016 Mar 22; 14(11):2546-53.
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Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. 2016 08; 107:160-167.
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Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening. Sci Rep. 2015 Nov 30; 5:17402.
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Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel. Biophys J. 2014 Jan 07; 106(1):134-44.
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Post-hypoxic recovery of respiratory rhythm generation is gender dependent. PLoS One. 2013; 8(4):e60695.
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Resonance in neocortical neurons and networks. Eur J Neurosci. 2012 Dec; 36(12):3698-708.