"Chromosomal Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
| Descriptor ID |
D043171
|
| MeSH Number(s) |
C23.550.210.110 C23.550.362.180 G05.365.590.175.165 G05.370.180
|
| Concept/Terms |
Chromosomal Instability- Chromosomal Instability
- Chromosomal Instabilities
- Instabilities, Chromosomal
- Instability, Chromosomal
- Chromosome Instability
- Chromosome Instabilities
- Instabilities, Chromosome
- Instability, Chromosome
Chromosome Stability- Chromosome Stability
- Chromosome Stabilities
- Stabilities, Chromosome
- Stability, Chromosome
- Chromosomal Stability
- Chromosomal Stabilities
- Stabilities, Chromosomal
- Stability, Chromosomal
|
Below are MeSH descriptors whose meaning is more general than "Chromosomal Instability".
Below are MeSH descriptors whose meaning is more specific than "Chromosomal Instability".
This graph shows the total number of publications written about "Chromosomal Instability" by people in this website by year, and whether "Chromosomal Instability" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 2 | 3 |
| 2011 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromosomal Instability" by people in Profiles.
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p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition. Nat Commun. 2022 10 20; 13(1):6206.
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Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel. Sci Transl Med. 2021 Sep 08; 13(610):eabd4811.
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Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide. Clin Cancer Res. 2021 07 15; 27(14):4077-4088.
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STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability. Cancer Res. 2019 04 01; 79(7):1465-1479.
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Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol. 2014 Sep; 34(17):3244-58.
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A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability. Cancer Res. 2014 Jul 15; 74(14):3707-15.
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Personalized colon cancer care in 2010. Semin Oncol. 2011 Apr; 38(2):284-308.
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Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth. Mol Cell. 2010 Sep 24; 39(6):862-72.
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Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification. Cancer Res. 2010 Jun 15; 70(12):5074-84.
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Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C. Cancer Res. 2010 Jun 15; 70(12):5085-95.