Mitogen-Activated Protein Kinase 8
"Mitogen-Activated Protein Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.
Descriptor ID |
D048055
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MeSH Number(s) |
D08.811.913.696.620.682.700.567.374.500 D12.644.360.450.340.500 D12.776.476.450.340.500
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Concept/Terms |
Mitogen-Activated Protein Kinase 8- Mitogen-Activated Protein Kinase 8
- Mitogen Activated Protein Kinase 8
- c-jun Kinase-1
- c jun Kinase 1
- SAP Kinase-1
- SAP Kinase 1
- Stress-Activated Protein Kinase gamma
- Stress Activated Protein Kinase gamma
- c-jun N-Terminal Kinase 1
- c jun N Terminal Kinase 1
- MAPK8 Mitogen-Activated Protein Kinase
- MAPK8 Mitogen Activated Protein Kinase
- JNK1 Kinase
- SAPK1 Mitogen-Activated Protein Kinase
- SAPK1 Mitogen Activated Protein Kinase
- Stress-Activated Protein Kinase 1
- Stress Activated Protein Kinase 1
- Stress-Activated Protein Kinase JNK1
- Stress Activated Protein Kinase JNK1
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Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 8".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 8".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 8" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 8" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 2 | 2 |
2003 | 0 | 1 | 1 |
2004 | 1 | 0 | 1 |
2006 | 1 | 1 | 2 |
2008 | 2 | 0 | 2 |
2009 | 3 | 1 | 4 |
2010 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2012 | 0 | 1 | 1 |
2015 | 1 | 0 | 1 |
2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 8" by people in Profiles.
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SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase. Cell Death Differ. 2018 09; 25(9):1638-1656.
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How to deal with multiple binding poses in alchemical relative protein-ligand binding free energy calculations. J Chem Theory Comput. 2015 Jun 09; 11(6):2670-9.
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Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation. 2014 Apr 22; 129(16):1650-8.
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Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma. Oncogene. 2013 Sep 05; 32(36):4231-42.
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Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011 Mar 10; 471(7337):220-4.
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CD95 promotes tumour growth. Nature. 2010 May 27; 465(7297):492-6.
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Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation. J Biol Chem. 2010 Feb 12; 285(7):4511-9.
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Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18279-84.
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JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem. 2009 Sep 25; 284(39):26591-602.
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Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2009 Sep; 297(3):L520-9.