Protein Inhibitors of Activated STAT
"Protein Inhibitors of Activated STAT" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally related proteins that are constitutively expressed and that negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. PIAS proteins inhibit the activity of signal transducers and activators of transcription.
Descriptor ID |
D050828
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MeSH Number(s) |
D12.644.360.024.319 D12.776.157.057.124 D12.776.476.024.402
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Inhibitors of Activated STAT".
Below are MeSH descriptors whose meaning is more specific than "Protein Inhibitors of Activated STAT".
This graph shows the total number of publications written about "Protein Inhibitors of Activated STAT" by people in this website by year, and whether "Protein Inhibitors of Activated STAT" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2009 | 1 | 0 | 1 |
2011 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Inhibitors of Activated STAT" by people in Profiles.
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Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-d. Nat Immunol. 2013 May; 14(5):461-9.
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Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9.
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Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-a-induced JNK activation and inflammation. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):191-6.
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Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18279-84.