 Proteasome Endopeptidase Complex
"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
| Descriptor ID |
D046988
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| MeSH Number(s) |
D05.500.562.500 D08.811.277.656.918 D08.811.600.730
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| Concept/Terms |
Proteasome Endopeptidase Complex- Proteasome Endopeptidase Complex
- Complex, Proteasome Endopeptidase
- Endopeptidase Complex, Proteasome
- Macropain
- Proteasome
- Multicatalytic Endopeptidase Complex
- Complex, Multicatalytic Endopeptidase
- Endopeptidase Complex, Multicatalytic
- Multicatalytic Proteinase
- Proteinase, Multicatalytic
- Prosome
- 20S Proteasome
- Proteasome, 20S
- Macroxyproteinase
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Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".
Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".
This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 4 | 4 | | 2001 | 0 | 4 | 4 | | 2002 | 0 | 7 | 7 | | 2003 | 0 | 3 | 3 | | 2004 | 4 | 3 | 7 | | 2005 | 0 | 1 | 1 | | 2006 | 3 | 0 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 3 | 3 | | 2009 | 1 | 6 | 7 | | 2010 | 3 | 2 | 5 | | 2011 | 0 | 5 | 5 | | 2012 | 0 | 2 | 2 | | 2013 | 2 | 3 | 5 | | 2014 | 1 | 5 | 6 | | 2015 | 1 | 2 | 3 | | 2016 | 2 | 1 | 3 | | 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.
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Ma Q, Ruan H, Peng L, Zhang M, Gack MU, Yao WD. Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8760-E8769.
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Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK. Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017 Jul 04; 8(27):43733-43751.
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Yoo YD, Lee DH, Cha-Molstad H, Kim H, Mun SR, Ji C, Park SH, Sung KS, Choi SA, Hwang J, Park DM, Kim SK, Park KJ, Kang SH, Oh SC, Ciechanover A, Lee YJ, Kim BY, Kwon YT. Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition. EMBO Rep. 2017 01; 18(1):150-168.
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Inaba Y, Ueno N, Numata M, Zhu X, Messer JS, Boone DL, Fujiya M, Kohgo Y, Musch MW, Chang EB. Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G634-G647.
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McConnell SC, Hernandez KM, Wcisel DJ, Kettleborough RN, Stemple DL, Yoder JA, Andrade J, de Jong JL. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):E5014-23.
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Kim H, Rodriguez-Navas C, Kollipara RK, Kapur P, Pedrosa I, Brugarolas J, Kittler R, Ye J. Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of ß-Catenin. Cell Rep. 2015 Oct 20; 13(3):495-503.
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Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M. c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell Rep. 2015 Aug 11; 12(6):1006-18.
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Tsabar M, Eapen VV, Mason JM, Memisoglu G, Waterman DP, Long MJ, Bishop DK, Haber JE. Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2. Nucleic Acids Res. 2015 Aug 18; 43(14):6889-901.
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Claud EC, McDonald JA, He SM, Yu Y, Duong L, Sun J, Petrof EO. Differential expression of 26S proteasome subunits and functional activity during neonatal development. Biomolecules. 2014 Aug 29; 4(3):812-26.
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Qiang L, He YY. Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition. Autophagy. 2014 Oct 01; 10(10):1864-5.
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