"Connexins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.
| Descriptor ID |
D017630
|
| MeSH Number(s) |
D12.776.543.585.250
|
| Concept/Terms |
Connexins- Connexins
- Gap Junction Protein
- Junction Protein, Gap
- Gap Junction Proteins
- Junction Proteins, Gap
- Gap Junction Channel Proteins
|
Below are MeSH descriptors whose meaning is more general than "Connexins".
Below are MeSH descriptors whose meaning is more specific than "Connexins".
This graph shows the total number of publications written about "Connexins" by people in this website by year, and whether "Connexins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1997 | 4 | 0 | 4 |
| 1998 | 0 | 2 | 2 |
| 1999 | 3 | 1 | 4 |
| 2000 | 9 | 1 | 10 |
| 2001 | 5 | 0 | 5 |
| 2002 | 4 | 3 | 7 |
| 2003 | 2 | 1 | 3 |
| 2004 | 7 | 2 | 9 |
| 2005 | 1 | 1 | 2 |
| 2006 | 2 | 0 | 2 |
| 2007 | 3 | 2 | 5 |
| 2008 | 5 | 0 | 5 |
| 2009 | 4 | 0 | 4 |
| 2010 | 1 | 0 | 1 |
| 2011 | 5 | 0 | 5 |
| 2012 | 4 | 1 | 5 |
| 2013 | 2 | 1 | 3 |
| 2014 | 7 | 0 | 7 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2017 | 6 | 0 | 6 |
| 2018 | 3 | 0 | 3 |
| 2019 | 2 | 0 | 2 |
| 2020 | 3 | 1 | 4 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 1 | 2 |
| 2025 | 1 | 0 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Connexins" by people in Profiles.
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Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. Int J Mol Sci. 2026 Mar 21; 27(6).
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ATP-release pannexin channels are gated by lysophospholipids. Elife. 2025 May 01; 14.
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Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket. Biol Res. 2024 May 23; 57(1):31.
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Assessment of blood-brain barrier leakage and brain oxygenation in Connexin-32 knockout mice with systemic neuroinflammation using pulse electron paramagnetic resonance imaging techniques. Magn Reson Med. 2024 06; 91(6):2519-2531.
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Exome Sequencing and the Identification of New Genes and Shared Mechanisms in Polymicrogyria. JAMA Neurol. 2023 09 01; 80(9):980-988.
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A crystallin mutant cataract with mineral deposits. J Biol Chem. 2023 08; 299(8):104935.
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Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice. Cells. 2022 09 07; 11(18).
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Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. J Biol Chem. 2022 03; 298(3):101673.
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Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant. Biophys J. 2021 12 21; 120(24):5644-5656.
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Free energy and kinetics of cAMP permeation through connexin26 via applied voltage and milestoning. Biophys J. 2021 08 03; 120(15):2969-2983.