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Melissa Pessin

InstitutionUniversity of Chicago
AddressChicago IL 60637
Phone+1 (773) 7021220 x54866
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    Collapse Overview 
    Collapse overview
    Dr. Pessin is a experienced Clinical Pathologist with additional board certification in Transfusion Medicine and Clinical Informatics. Her current interests are in pathology informatics, optimization of laboratory test utilization and new test methodologies.

    Collapse Biography 
    Collapse education and training
    Princeton University, Princeton, NJBS06/1984Electrical Engineering & Computer Science
    The Johns Hopkins University School of Medicine, Baltimore, MDMD05/1991Medicine
    The Johns Hopkins University School of Medicine, Baltimore, MDPhD05/1991Neuroscience
    The Rockefeller University, New York, NY06/1992Postdoctoral Fellow, Greengard Laboratory
    College of Physicians & Surgeons of Columbia University, New York, NY06/1995Clinical Pathology
    Memorial Sloan Kettering Cancer Center, New York, NY06/2019Physician Executive Development Program
    Collapse awards and honors
    2018The Pathologist's Power List 2018, The Pathologist

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Coller BS, Ghebrehiwet B, Pessin MS, Coller BS, Ghebrehiwet B, Pessin M. Ellinor Peerschke, PhD (1954-2023). J Thromb Haemost. 2023 Dec 15. PMID: 38104722.
      Citations:    Fields:    
    2. Ye F, Feldman DR, Valentino A, So R, Bromberg M, Khan S, Funt SA, Sheinfeld J, Solit DB, Pessin MS, Peerschke EI. Analytical Validation and Performance Characteristics of Molecular Serum Biomarkers, miR-371a-3p and miR-372-3p, for Male Germ Cell Tumors, in a Clinical Laboratory Setting. J Mol Diagn. 2022 08; 24(8):867-877. PMID: 35934321; PMCID: PMC9379668.
      Citations: 6     Fields:    Translation:Humans
    3. Foote MB, White JR, Jee J, Wan JCM, Rousseau B, Pessin MS, Diaz LA, Argilés G. Association of Antineoplastic Therapy With Decreased SARS-CoV-2 Infection Rates in Patients With Cancer. JAMA Oncol. 2021 11 01; 7(11):1686-1691. PMID: 34410305; PMCID: PMC8377603.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    4. Bolton KL, Koh Y, Foote MB, Im H, Jee J, Sun CH, Safonov A, Ptashkin R, Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M, Derkach A, Gedvilaite E, Tkachuk KA, Wiley BJ, Chan IC, Braunstein LZ, Gao T, Papaemmanuil E, Esther Babady N, Pessin MS, Kamboj M, Diaz LA, Ladanyi M, Rauh MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V, Offit K, Norton L, Berger MF, Levine RL, Kim ES, Kim NJ, Zehir A. Clonal hematopoiesis is associated with risk of severe Covid-19. Nat Commun. 2021 10 13; 12(1):5975. PMID: 34645798; PMCID: PMC8514469.
      Citations: 47     Fields:    Translation:HumansCells
    5. Chung DJ, Shah GL, Devlin SM, Ramanathan LV, Doddi S, Pessin MS, Hoover E, Marcello LT, Young JC, Boutemine SR, Serrano E, Sharan S, Momotaj S, Margetich L, Bravo CD, Papanicolaou GA, Kamboj M, Mato AR, Roeker LE, Hultcrantz M, Mailankody S, Lesokhin AM, Vardhana SA, Knorr DA. Disease- and Therapy-Specific Impact on Humoral Immune Responses to COVID-19 Vaccination in Hematologic Malignancies. Blood Cancer Discov. 2021 11; 2(6):568-576. PMID: 34778797; PMCID: PMC8580617.
      Citations: 41     Fields:    Translation:HumansCellsPHPublic Health
    6. Tamari R, Politikos I, Knorr DA, Vardhana SA, Young JC, Marcello LT, Doddi S, Devlin SM, Ramanathan LV, Pessin MS, Dunn E, Palazzo M, Bravo CD, Papanicolaou GA, Kamboj M, Perales MA, Chung DJ, Shah GL. Predictors of Humoral Response to SARS-CoV-2 Vaccination after Hematopoietic Cell Transplantation and CAR T-cell Therapy. Blood Cancer Discov. 2021 11; 2(6):577-585. PMID: 34778798; PMCID: PMC8580614.
      Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
    7. Kramer K, Donzelli MA, Pessin MS. Correction to: Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy. Cancer Immunol Immunother. 2021 Aug; 70(8):2415. PMID: 33929584; PMCID: PMC8289750.
      Citations:    Fields:    
    8. Crawford JM, Aguero-Rosenfeld ME, Aifantis I, Cadoff EM, Cangiarella JF, Cordon-Cardo C, Cushing M, Firpo-Betancourt A, Fox AS, Furuya Y, Hacking S, Jhang J, Leonard DGB, Libien J, Loda M, Mendu DR, Mulligan MJ, Nasr MR, Pecora ND, Pessin MS, Prystowsky MB, Ramanathan LV, Rauch KR, Riddell S, Roach K, Roth KA, Shroyer KR, Smoller BR, Spitalnik SL, Spitzer ED, Tomaszewski JE, Waltman S, Willis L, Sumer-King Z. The New York State SARS-CoV-2 Testing Consortium: Regional Communication in Response to the COVID-19 Pandemic. Acad Pathol. 2021 Jan-Dec; 8:23742895211006818. PMID: 34013020; PMCID: PMC8107494.
      Citations: 3     
    9. Kramer K, Donzelli MA, Pessin MS. Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy. Cancer Immunol Immunother. 2021 Aug; 70(8):2411-2414. PMID: 33533945; PMCID: PMC8289752.
      Citations:    Fields:    Translation:HumansCells
    10. Bolton KL, Koh Y, Foote MB, Im H, Jee J, Sun CH, Safonov A, Ptashkin R, Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M, Derkach A, Gedvilaite E, Tkachuk KA, Braunstein LZ, Gao T, Papaemmanuil E, Babady NE, Pessin MS, Kamboj M, Diaz LA, Ladanyi M, Rauh MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V, Offit K, Norton L, Berger MF, Levine RL, Kim ES, Kim NJ, Zehir A. Clonal hematopoiesis is associated with risk of severe Covid-19. medRxiv. 2020 Nov 27. PMID: 33269365; PMCID: PMC7709186.
      Citations: 1     
    11. Schluter J, Peled JU, Taylor BP, Markey KA, Smith M, Taur Y, Niehus R, Staffas A, Dai A, Fontana E, Amoretti LA, Wright RJ, Morjaria S, Fenelus M, Pessin MS, Chao NJ, Lew M, Bohannon L, Bush A, Sung AD, Hohl TM, Perales MA, van den Brink MRM, Xavier JB. The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020 12; 588(7837):303-307. PMID: 33239790; PMCID: PMC7725892.
      Citations: 169     Fields:    Translation:HumansCells
    12. Kamboj M, Pessin M, Barber T, Covid-19 Subcommittee of the Operating Room Executive Committee. Comment on "Screening of Asymptomatic Surgical Patients for SARS-CoV-2: The Covid19 Subcommittee of the Operating Room Executive Committee"1. Ann Surg. 2020 09 01; 272(3):e243. PMID: 33759844; PMCID: PMC7467031.
      Citations:    Fields:    Translation:HumansCells
    13. Roeker LE, Knorr DA, Pessin MS, Ramanathan LV, Thompson MC, Leslie LA, Zelenetz AD, Mato AR. Anti-SARS-CoV-2 antibody response in patients with chronic lymphocytic leukemia. Leukemia. 2020 11; 34(11):3047-3049. PMID: 32855439; PMCID: PMC7450257.
      Citations: 50     Fields:    Translation:HumansCellsPHPublic Health
    14. Jee J, Foote MB, Lumish M, Stonestrom AJ, Wills B, Narendra V, Avutu V, Murciano-Goroff YR, Chan JE, Derkach A, Philip J, Belenkaya R, Kerpelev M, Maloy M, Watson A, Fong C, Janjigian Y, Diaz LA, Bolton KL, Pessin MS. Chemotherapy and COVID-19 Outcomes in Patients With Cancer. J Clin Oncol. 2020 10 20; 38(30):3538-3546. PMID: 32795225; PMCID: PMC7571792.
      Citations: 133     Fields:    Translation:HumansCellsPHPublic Health
    15. Samoila A, Sosa J, Padilla J, Wutkowski M, Vanness K, Viale A, Berger M, Houck-Loomis B, Pessin M, Peerschke EI. Developing Quality Programs for Cell-Free DNA (cfDNA) Extraction from Peripheral Blood. J Appl Lab Med. 2020 07 01; 5(4):788-797. PMID: 32603443.
      Citations: 3     Fields:    Translation:Humans
    16. Erdman P, Ramanathan L, Fleisher M, Pessin M. Confounding Hyponatremia and Hypochloremia in a Cancer Patient. J Appl Lab Med. 2020 05 01; 5(3):588-591. PMID: 32445347; PMCID: PMC7192545.
      Citations:    Fields:    Translation:Humans
    17. Schofield RC, Landau HJ, Giralt SA, Shah GL, Scordo M, Lin A, Zanutto E, Ramanathan LV, Pessin MS, Carlow DC. Measurement of the DNA alkylating agents busulfan and melphalan in human plasma by mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 01; 1125:121711. PMID: 31376591; PMCID: PMC6692901.
      Citations: 4     Fields:    Translation:Humans
    18. Chen J, Goss C, Avecilla ST, Hong H, Walsh E, Wuest D, Maslak P, Pessin MS. Evaluation of peripheral blood mononuclear cell collection by leukapheresis. Transfusion. 2019 05; 59(5):1765-1772. PMID: 30747437; PMCID: PMC7416722.
      Citations: 4     Fields:    Translation:HumansCells
    19. Schofield RC, Ramanathan LV, Pessin MS, Carlow DC. Data to support a simultaneous testosterone and estradiol assay in serum by LC-MS/MS. Data Brief. 2018 Oct; 20:1160-1165. PMID: 30246107; PMCID: PMC6141700.
      Citations: 2     
    20. Carroll BL, Fleisher M, Pessin MS, Ramanathan LV. Elevated Alkaline Phosphatase in a Cancer Patient: Think You Know the Source? J Appl Lab Med. 2017 Nov 01; 2(3):440-443. PMID: 33636839; PMCID: PMC8285034.
      Citations:    Fields:    
    21. McCash SI, Goldfrank DJ, Pessin MS, Ramanathan LV. Reducing False-Positive Pregnancy Test Results in Patients With Cancer. Obstet Gynecol. 2017 10; 130(4):825-829. PMID: 28885416; PMCID: PMC5724973.
      Citations: 2     Fields:    Translation:Humans
    22. Kaul KL, Sabatini LM, Tsongalis GJ, Caliendo AM, Olsen RJ, Ashwood ER, Bale S, Benirschke R, Carlow D, Funke BH, Grody WW, Hayden RT, Hegde M, Lyon E, Murata K, Pessin M, Press RD, Thomson RB. The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care. Acad Pathol. 2017 Jan-Dec; 4:2374289517708309. PMID: 28815200; PMCID: PMC5528950.
      Citations: 10     
    23. Carroll B, Fleisher M, Pessin MS, Richardson S, Ramanathan LV. Pseudohypocalcemia in Cancer Patients: A Recommendation for the Postanalytical Correction of Serum Calcium in Patients with Hypoalbuminemia. Clin Chem. 2017 07; 63(7):1302-1304. PMID: 28515104; PMCID: PMC8504653.
      Citations: 2     Fields:    Translation:Humans
    24. Mendu DR, Sternlicht H, Ramanathan LV, Pessin MS, Fleisher M, Dalbagni G, Jaimes EA, Kaltsas A, Glezerman IG. Two cases of spontaneous remission of non-parasitic chyluria. Clin Biochem. 2017 Oct; 50(15):886-888. PMID: 28478046; PMCID: PMC5586652.
      Citations: 5     Fields:    Translation:HumansAnimals
    25. Schofield RC, Mendu DR, Ramanathan LV, Pessin MS, Carlow DC. Sensitive simultaneous quantitation of testosterone and estradiol in serum by LC-MS/MS without derivatization and comparison with the CDC HoSt program. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 24; 1048:70-76. PMID: 28222335; PMCID: PMC5379634.
      Citations: 7     Fields:    Translation:Humans
    26. Isa F, Saito K, Huang YT, Schuetz A, Babady NE, Salvatore S, Pessin M, van Besien K, Perales MA, Giralt S, Sepkowitz K, Papanicolaou GA, Soave R, Kamboj M. Implementation of Molecular Surveillance After a Cluster of Fatal Toxoplasmosis at 2 Neighboring Transplant Centers. Clin Infect Dis. 2016 08 15; 63(4):565-8. PMID: 27199460; PMCID: PMC4967604.
      Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    27. Schofield RC, Ramanathan LV, Murata K, Fleisher M, Pessin MS, Carlow DC. Development of an Assay for Methotrexate and Its Metabolites 7-Hydroxy Methotrexate and DAMPA in Serum by LC-MS/MS. Methods Mol Biol. 2016; 1383:213-22. PMID: 26660190.
      Citations: 4     Fields:    Translation:Humans
    28. Magid MS, Shah DT, Cambor CL, Conran RM, Lin AY, Peerschke EIB, Pessin MS, Harris IB. Consensus Guidelines for Practical Competencies in Anatomic Pathology and Laboratory Medicine for the Undifferentiated Graduating Medical Student. Acad Pathol. 2015 Oct-Dec; 2(4):2374289515605336. PMID: 28725750; PMCID: PMC5479462.
    29. Schofield RC, Ramanathan LV, Murata K, Grace M, Fleisher M, Pessin MS, Carlow DC. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 01; 1002:169-75. PMID: 26322588; PMCID: PMC4982141.
      Citations: 7     Fields:    Translation:Humans
    30. Otto CC, Shuptar SL, Milord P, Essick CJ, Nevrekar R, Granovsky SL, Seo SK, Babady NE, Martin SC, Tang YW, Pessin MS. Reducing Unnecessary and Duplicate Ordering for Ovum and Parasite Examinations and Clostridium difficile PCR in Immunocompromised Patients by Using an Alert at the Time of Request in the Order Management System. J Clin Microbiol. 2015 Aug; 53(8):2745-8. PMID: 26063860; PMCID: PMC4508420.
      Citations: 4     Fields:    Translation:Humans
    31. Peerschke EI, Moung C, Pessin MS, Maslak P. Evaluation of new automated hematopoietic progenitor cell analysis in the clinical management of peripheral blood stem cell collections. Transfusion. 2015 Aug; 55(8):2001-9. PMID: 25808236; PMCID: PMC4976989.
      Citations: 8     Fields:    Translation:HumansCells
    32. Mendu DR, Fleisher M, McCash SI, Pessin MS, Ramanathan LV. D-lactic acidosis mediated neuronal encephalopathy in acute lymphoblastic leukemia patient: an under diagnosis. Clin Chim Acta. 2015 Feb 20; 441:90-1. PMID: 25542530.
      Citations: 1     Fields:    Translation:Humans
    33. Peerschke EI, Pessin MS, Maslak P. Using the hemoglobin content of reticulocytes (RET-He) to evaluate anemia in patients with cancer. Am J Clin Pathol. 2014 Oct; 142(4):506-12. PMID: 25239418; PMCID: PMC4962332.
      Citations: 7     Fields:    Translation:HumansCells
    34. Litvak A, Cercek A, Segal N, Reidy-Lagunes D, Stadler ZK, Yaeger RD, Kemeny NE, Weiser MR, Pessin MS, Saltz L. False-positive elevations of carcinoembryonic antigen in patients with a history of resected colorectal cancer. J Natl Compr Canc Netw. 2014 Jun; 12(6):907-13. PMID: 24925201; PMCID: PMC8409326.
      Citations: 41     Fields:    Translation:Humans
    35. Reich DL, Pessin MS. Rational preoperative blood type and screen testing criteria. Anesthesiology. 2012 Apr; 116(4):749-50. PMID: 22314294.
      Citations:    Fields:    Translation:HumansPHPublic Health
    36. Kavarana MN, Pessin-Minsley MS, Urtecho J, Catanese KA, Flannery M, Oz MC, Naka Y. Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem. Ann Thorac Surg. 2002 Mar; 73(3):745-50. PMID: 11899176.
      Citations: 52     Fields:    Translation:Humans
    37. Staib A, Dolenko B, Fink DJ, Nikulin AE, Otto M, Pessin-Minsley MS, Quarder O, Somorjai R, Thienel U, Werner G, Petrich W, Früh J. Disease pattern recognition testing for rheumatoid arthritis using infrared spectra of human serum. Clin Chim Acta. 2001 Jun; 308(1-2):79-89. PMID: 11412819.
      Citations: 5     Fields:    Translation:Humans
    38. Apple FS, Maturen AJ, Mullins RE, Painter PC, Pessin-Minsley MS, Webster RA, Spray Flores J, DeCresce R, Fink DJ, Buckley PM, Marsh J, Ricchiuti V, Christenson RH. Multicenter clinical and analytical evaluation of the AxSYM troponin-I immunoassay to assist in the diagnosis of myocardial infarction. Clin Chem. 1999 Feb; 45(2):206-12. PMID: 9931042.
      Citations: 6     Fields:    Translation:Humans
    39. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994 Dec 16; 266(5192):1865-9. PMID: 7997879.
      Citations: 1869     Fields:    Translation:HumansCells
    40. Kase CS, Pessin MS, Zivin JA, del Zoppo GJ, Furlan AJ, Buckley JW, Snipes RG, LittleJohn JK. Intracranial hemorrhage after coronary thrombolysis with tissue plasminogen activator. Am J Med. 1992 Apr; 92(4):384-90. PMID: 1558085.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
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