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David Zemmour

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
Email
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    We are a multidisciplinary team with a passion for understanding immune T-cell responses in health and diseases. We study Tregs, unique cells in our body that specialize in preventing autoimmune diseases. We take the unique perspective to look at cellular interactions, i.e. how Tregs talk to other cells to do maintain tolerance, promote tissue homeostasis, and contribute to pathogenesis. We explore the role of Tregs directly in human tissues using Systems and Synthetic Biology approaches that illuminate these interactions.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lebron Figueroa A, Magill I, Zemmour D, Starnbach MN. Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response. J Immunol. 2026 Jun 07; 215(6). PMID: 42413199; PMCID: PMC13341007.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Thefaine CE, Lucas ED, Block KE, Pierson M, Dehm EM, Huggins MA, Casey OW, Zemmour D, Jameson SC, Hamilton SE, immgenT Project. Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function. bioRxiv. 2026 Feb 04. PMID: 41676686; PMCID: PMC12889659.
      Citations:    
    3. Galletti G, Globig AM, Barreiro O, Heim TA, Liu S, Borys SM, Casey O, Monell A, Patravali D, Scharping NE, Quon S, Takehara KK, Ferry A, Cheung KP, Duong E, Shinkawa T, Spranger S, Behar SM, Kaech SM, Goldrath AW, Zemmour D, immgenT Project. The CD8 immgenT framework as a universal reference of mouse CD8aß T cell differentiation states. bioRxiv. 2026 Feb 04. PMID: 41676596; PMCID: PMC12889609.
      Citations:    
    4. Weiss ES, Hirai T, Li H, Liu A, Baker S, Magill I, Gillis J, Zhang YR, Ramcke T, Kurihara K, ImmGen Consortium OpenSource T cell Project, Masopust D, Anandasabapathy N, Singh H, Zemmour D, Mackay LK, Kaplan DH. Epidermal resident memory T cell fitness requires antigen encounter in the skin. Elife. 2025 Dec 30; 14. PMID: 41468295; PMCID: PMC12753104.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Reilly SP, Smith ML, Borys SM, Fugère C, Demers D, Hogan MJ, Zemmour D, Brossay L. Unconventional CD8+ T cell surveillance of cytomegalovirus via Qa-1/HLA-E-restricted epitope recognition. Sci Adv. 2025 12 19; 11(51):eaea8707. PMID: 41417899; PMCID: PMC12716397.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. AlJabban A, Azevedo RS, Antel K, Arnette A, Cohen EF, Meredith DM, Murakami MA, Sholl LM, Tolstorukov MY, Tsai HK, Tsai JM, Zemmour D, Lindeman NI, Garcia E, Brown JR, Kim AS. Mutational signature analysis of chronic lymphocytic leukemia uncovering genomic patterns and prognostic implications. Am J Clin Pathol. 2025 10 04; 164(4):530-544. PMID: 40814292.
      Citations:    Fields:    Translation:Humans
    7. Magill I, Piekarsa V, Kossida S, Croteau J, Lee A, Balderas R, Zemmour D, Benoist C, immgenT Project . Genomic specificity of anti-mouse TCR mAbs determined by single-cell RNAseq. J Immunol. 2025 Sep 01; 214(9):2202-2210. PMID: 40751448; PMCID: PMC12481028.
      Citations:    Fields:    Translation:AnimalsCells
    8. Weiss ES, Hirai T, Li H, Liu A, Baker S, Magill I, Gillis J, Zhang YR, Ramcke T, Kurihara K, ImmGen Consortium OpenSource T cell Project, Masopust D, Anandasabapathy N, Singh H, Zemmour D, Mackay LK, Kaplan DH. Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin. bioRxiv. 2025 Jul 09. PMID: 40236062; PMCID: PMC11996394.
      Citations:    
    9. Olivas AD, Mou Ngai PC, Schahrer E, Xing J, Ghadiri M, Olortegui KS, Cursio JF, Akiyama S, Chang EB, Shen L, Umanskiy K, Rubin DT, Zemmour D, Weber CR, Olivas AD, Mou Ngai PC, Schahrer E, Xing J, Ghadiri M, Olortegui KS, Cursio JF, Chang EB, Shen L, Umanskiy K, Rubin DT, Zemmour D, Weber CR. Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2025; 19(10):101563. PMID: 40571096; PMCID: PMC12362706.
      Citations:    Fields:    Translation:HumansCells
    10. Olivas AD, Ngai PCM, Schahrer E, Olortegui KS, Cursio JF, Akiyama S, Chang EB, Shen L, Umanskiy K, Rubin DT, Zemmour D, Weber CR. Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease. bioRxiv. 2025 Jan 28. PMID: 39974918; PMCID: PMC11838289.
      Citations:    
    11. Borys SM, Reilly SP, Magill I, Zemmour D, Brossay L. NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1-PD-L1. Sci Immunol. 2024 12 20; 9(102):eadl2967. PMID: 39705335; PMCID: PMC12099074.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Sadigh S, DeAngelo DJ, Garcia JS, Hasserjian RP, Hergott CB, Lane AA, Lovitch SB, Lucas F, Luskin MR, Morgan EA, Pinkus GS, Pozdnyakova O, Rodig SJ, Shanmugam V, Tsai HK, Winer ES, Zemmour D, Kim AS. Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow. Mod Pathol. 2024 01; 37(1):100352. PMID: 37839675.
      Citations: 6     Fields:    Translation:HumansCells
    13. Larocca C, Shanmugam V, Zemmour D, Antin JH, Lane AA. Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient. Am J Dermatopathol. 2022 12 01; 44(12):929-932. PMID: 35642960.
      Citations:    Fields:    Translation:HumansCells
    14. Zemmour D, Goldrath A, Kronenberg M, Kang J, Benoist C. The ImmGen consortium OpenSource T cell project. Nat Immunol. 2022 05; 23(5):643-644. PMID: 35469020.
      Citations: 10     Fields:    Translation:Cells
    15. Corchado-Garcia J, Zemmour D, Hughes T, Bandi H, Cristea-Platon T, Lenehan P, Pawlowski C, Bade S, O'Horo JC, Gores GJ, Williams AW, Badley AD, Halamka J, Virk A, Swift MD, Wagner T, Soundararajan V. Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19. JAMA Netw Open. 2021 11 01; 4(11):e2132540. PMID: 34726743; PMCID: PMC8564583.
      Citations: 57     Fields:    Translation:HumansCellsPHPublic Health
    16. Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). PMID: 34403365; PMCID: PMC8492304.
      Citations: 26     Fields:    Translation:AnimalsCells
    17. Porritt RA, Zemmour D, Abe M, Lee Y, Narayanan M, Carvalho TT, Gomez AC, Martinon D, Santiskulvong C, Fishbein MC, Chen S, Crother TR, Shimada K, Arditi M, Noval Rivas M. NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis. Circ Res. 2021 10 15; 129(9):e183-e200. PMID: 34517723; PMCID: PMC8555446.
      Citations: 47     Fields:    Translation:AnimalsCells
    18. Venkatakrishnan AJ, Pawlowski C, Zemmour D, Hughes T, Anand A, Berner G, Kayal N, Puranik A, Conrad I, Bade S, Barve R, Sinha P, O'Horo JC, Badley AD, Halamka J, Soundararajan V. Mapping each pre-existing condition's association to short-term and long-term COVID-19 complications. NPJ Digit Med. 2021 Jul 27; 4(1):117. PMID: 34315980; PMCID: PMC8316410.
      Citations: 19     
    19. Doddahonnaiah D, Lenehan PJ, Hughes TK, Zemmour D, Garcia-Rivera E, Venkatakrishnan AJ, Chilaka R, Khare A, Kasaraneni A, Garg A, Anand A, Barve R, Thiagarajan V, Soundararajan V. A Literature-Derived Knowledge Graph Augments the Interpretation of Single Cell RNA-seq Datasets. Genes (Basel). 2021 06 10; 12(6). PMID: 34200671; PMCID: PMC8229796.
      Citations: 6     Fields:    Translation:Humans
    20. Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, Garcia-Lloret MI, Ruemmele FM, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, Chatila TA, Mathis D, Benoist C, André I. Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat Immunol. 2021 05; 22(5):607-619. PMID: 33833438; PMCID: PMC8173714.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    21. Venkatakrishnan AJ, Puranik A, Anand A, Zemmour D, Yao X, Wu X, Chilaka R, Murakowski DK, Standish K, Raghunathan B, Wagner T, Garcia-Rivera E, Solomon H, Garg A, Barve R, Anyanwu-Ofili A, Khan N, Soundararajan V. Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors. Elife. 2020 05 28; 9. PMID: 32463365; PMCID: PMC7371427.
      Citations: 45     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    22. Zemmour D, Kiner E, Benoist C. CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics. Curr Opin Immunol. 2020 04; 63:61-67. PMID: 32259715; PMCID: PMC7198319.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    23. Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D. Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5402-5408. PMID: 32102913; PMCID: PMC7071852.
      Citations: 32     Fields:    Translation:AnimalsCells
    24. Spallanzani RG, Zemmour D, Xiao T, Jayewickreme T, Li C, Bryce PJ, Benoist C, Mathis D. Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors. Sci Immunol. 2019 05 03; 4(35). PMID: 31053654; PMCID: PMC6648660.
      Citations: 137     Fields:    Translation:AnimalsCells
    25. Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. Immunity. 2019 05 21; 50(5):1317-1334.e10. PMID: 30979687; PMCID: PMC6620049.
      Citations: 886     Fields:    Translation:HumansAnimalsCells
    26. DiSpirito JR, Zemmour D, Ramanan D, Cho J, Zilionis R, Klein AM, Benoist C, Mathis D. Molecular diversification of regulatory T cells in nonlymphoid tissues. Sci Immunol. 2018 09 14; 3(27). PMID: 30217811; PMCID: PMC6219455.
      Citations: 89     Fields:    Translation:AnimalsCells
    27. Li C, DiSpirito JR, Zemmour D, Spallanzani RG, Kuswanto W, Benoist C, Mathis D. TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype. Cell. 2018 07 12; 174(2):285-299.e12. PMID: 29887374; PMCID: PMC6046274.
      Citations: 149     Fields:    Translation:AnimalsCells
    28. Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nat Immunol. 2018 06; 19(6):645. PMID: 29725080.
      Citations: 2     Fields:    
    29. Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nat Immunol. 2018 03; 19(3):291-301. PMID: 29434354; PMCID: PMC6069633.
      Citations: 233     Fields:    Translation:HumansAnimalsCells
    30. Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ, Faget J, Meylan E. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017 12 01; 358(6367). PMID: 29191879; PMCID: PMC6343476.
      Citations: 227     Fields:    Translation:HumansAnimalsCells
    31. Zemmour D, Pratama A, Loughhead SM, Mathis D, Benoist C. Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3472-E3480. PMID: 28396406; PMCID: PMC5410798.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    32. Zilionis R, Nainys J, Veres A, Savova V, Zemmour D, Klein AM, Mazutis L. Single-cell barcoding and sequencing using droplet microfluidics. Nat Protoc. 2017 Jan; 12(1):44-73. PMID: 27929523.
      Citations: 351     Fields:    
    33. Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells. Science. 2015 Aug 28; 349(6251):993-7. PMID: 26272906; PMCID: PMC4700932.
      Citations: 536     Fields:    Translation:HumansAnimalsCells
    34. Meredith M, Zemmour D, Mathis D, Benoist C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat Immunol. 2015 Sep; 16(9):942-9. PMID: 26237550; PMCID: PMC4632529.
      Citations: 130     Fields:    Translation:AnimalsCells
    35. Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A, ImmGen Consortium. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2946-51. PMID: 23382184; PMCID: PMC3581886.
      Citations: 218     Fields:    Translation:HumansAnimalsCells
    36. Petit V, Puyraimond-Zemmour D, Aynaud MM, Henry M, Rusniok C, Wain-Hobson S, Vartanian JP, Suspène R, Guétard D. Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines. J Virol. 2011 Mar; 85(5):2458-62. PMID: 21159878; PMCID: PMC3067779.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    37. Renard M, Henry M, Puyraimond-Zemmour D, Tangy F, Vartanian JP, Wain-Hobson S, Suspène R, Guétard D, Billecocq A, Bouloy M. Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs. Nucleic Acids Res. 2008 Jul; 36(12):e72. PMID: 18515351; PMCID: PMC2475633.
      Citations: 22     Fields:    Translation:AnimalsCells
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