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David Zemmour

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    We are a multidisciplinary team with a passion for understanding immune T-cell responses in health and diseases. We study Tregs, unique cells in our body that specialize in preventing autoimmune diseases. We take the unique perspective to look at cellular interactions, i.e. how Tregs talk to other cells to do maintain tolerance, promote tissue homeostasis, and contribute to pathogenesis. We explore the role of Tregs directly in human tissues using Systems and Synthetic Biology approaches that illuminate these interactions.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Larocca C, Shanmugam V, Zemmour D, Antin JH, Lane AA. Shared Clonal Origin of Multiple Histiocytic and Dendritic Neoplasms and Polycythemia Vera, Follicular Lymphoma in 1 Patient. Am J Dermatopathol. 2022 12 01; 44(12):929-932. PMID: 35642960.
      View in: PubMed
    2. Zemmour D, Goldrath A, Kronenberg M, Kang J, Benoist C. The ImmGen consortium OpenSource T cell project. Nat Immunol. 2022 05; 23(5):643-644. PMID: 35469020.
      View in: PubMed
    3. Corchado-Garcia J, Zemmour D, Hughes T, Bandi H, Cristea-Platon T, Lenehan P, Pawlowski C, Bade S, O'Horo JC, Gores GJ, Williams AW, Badley AD, Halamka J, Virk A, Swift MD, Wagner T, Soundararajan V. Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19. JAMA Netw Open. 2021 11 01; 4(11):e2132540. PMID: 34726743.
      View in: PubMed
    4. Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). PMID: 34403365.
      View in: PubMed
    5. Porritt RA, Zemmour D, Abe M, Lee Y, Narayanan M, Carvalho TT, Gomez AC, Martinon D, Santiskulvong C, Fishbein MC, Chen S, Crother TR, Shimada K, Arditi M, Noval Rivas M. NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis. Circ Res. 2021 10 15; 129(9):e183-e200. PMID: 34517723.
      View in: PubMed
    6. Venkatakrishnan AJ, Pawlowski C, Zemmour D, Hughes T, Anand A, Berner G, Kayal N, Puranik A, Conrad I, Bade S, Barve R, Sinha P, O'Horo JC, Badley AD, Halamka J, Soundararajan V. Mapping each pre-existing condition's association to short-term and long-term COVID-19 complications. NPJ Digit Med. 2021 Jul 27; 4(1):117. PMID: 34315980.
      View in: PubMed
    7. Doddahonnaiah D, Lenehan PJ, Hughes TK, Zemmour D, Garcia-Rivera E, Venkatakrishnan AJ, Chilaka R, Khare A, Kasaraneni A, Garg A, Anand A, Barve R, Thiagarajan V, Soundararajan V. A Literature-Derived Knowledge Graph Augments the Interpretation of Single Cell RNA-seq Datasets. Genes (Basel). 2021 06 10; 12(6). PMID: 34200671.
      View in: PubMed
    8. Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, Garcia-Lloret MI, Ruemmele FM, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, Andr? I, Chatila TA, Mathis D, Benoist C. Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat Immunol. 2021 05; 22(5):607-619. PMID: 33833438.
      View in: PubMed
    9. Venkatakrishnan AJ, Puranik A, Anand A, Zemmour D, Yao X, Wu X, Chilaka R, Murakowski DK, Standish K, Raghunathan B, Wagner T, Garcia-Rivera E, Solomon H, Garg A, Barve R, Anyanwu-Ofili A, Khan N, Soundararajan V. Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors. Elife. 2020 05 28; 9. PMID: 32463365.
      View in: PubMed
    10. Zemmour D, Kiner E, Benoist C. CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics. Curr Opin Immunol. 2020 04; 63:61-67. PMID: 32259715.
      View in: PubMed
    11. Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D. Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5402-5408. PMID: 32102913.
      View in: PubMed
    12. Spallanzani RG, Zemmour D, Xiao T, Jayewickreme T, Li C, Bryce PJ, Benoist C, Mathis D. Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors. Sci Immunol. 2019 05 03; 4(35). PMID: 31053654.
      View in: PubMed
    13. Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. Immunity. 2019 05 21; 50(5):1317-1334.e10. PMID: 30979687.
      View in: PubMed
    14. DiSpirito JR, Zemmour D, Ramanan D, Cho J, Zilionis R, Klein AM, Benoist C, Mathis D. Molecular diversification of regulatory T cells in nonlymphoid tissues. Sci Immunol. 2018 09 14; 3(27). PMID: 30217811.
      View in: PubMed
    15. Li C, DiSpirito JR, Zemmour D, Spallanzani RG, Kuswanto W, Benoist C, Mathis D. TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype. Cell. 2018 07 12; 174(2):285-299.e12. PMID: 29887374.
      View in: PubMed
    16. Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nat Immunol. 2018 06; 19(6):645. PMID: 29725080.
      View in: PubMed
    17. Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nat Immunol. 2018 03; 19(3):291-301. PMID: 29434354.
      View in: PubMed
    18. Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017 12 01; 358(6367). PMID: 29191879.
      View in: PubMed
    19. Zemmour D, Pratama A, Loughhead SM, Mathis D, Benoist C. Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3472-E3480. PMID: 28396406.
      View in: PubMed
    20. Zilionis R, Nainys J, Veres A, Savova V, Zemmour D, Klein AM, Mazutis L. Single-cell barcoding and sequencing using droplet microfluidics. Nat Protoc. 2017 Jan; 12(1):44-73. PMID: 27929523.
      View in: PubMed
    21. Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells. Science. 2015 Aug 28; 349(6251):993-7. PMID: 26272906.
      View in: PubMed
    22. Meredith M, Zemmour D, Mathis D, Benoist C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat Immunol. 2015 Sep; 16(9):942-9. PMID: 26237550.
      View in: PubMed
    23. Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2946-51. PMID: 23382184.
      View in: PubMed
    24. Susp?ne R, Petit V, Puyraimond-Zemmour D, Aynaud MM, Henry M, Gu?tard D, Rusniok C, Wain-Hobson S, Vartanian JP. Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines. J Virol. 2011 Mar; 85(5):2458-62. PMID: 21159878.
      View in: PubMed
    25. Susp?ne R, Renard M, Henry M, Gu?tard D, Puyraimond-Zemmour D, Billecocq A, Bouloy M, Tangy F, Vartanian JP, Wain-Hobson S. Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs. Nucleic Acids Res. 2008 Jul; 36(12):e72. PMID: 18515351.
      View in: PubMed
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