PAX5 Transcription Factor
"PAX5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A paired box transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES. It functions both as a transcriptional activator and repressor to mediate B-cell commitment.
| Descriptor ID |
D051757
|
| MeSH Number(s) |
D12.776.260.645.500 D12.776.930.700.500
|
| Concept/Terms |
PAX5 Transcription Factor- PAX5 Transcription Factor
- Transcription Factor, PAX5
- B-Cell-Specific Activator Protein
- B Cell Specific Activator Protein
- Transcription Factor PAX5
- PAX5, Transcription Factor
- Paired Box 5 Protein
- B Cell-Specific Transcription Factor
- B Cell Specific Transcription Factor
- Early B Cell-Specific Binding Protein-1
- Early B Cell Specific Binding Protein 1
|
Below are MeSH descriptors whose meaning is more general than "PAX5 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "PAX5 Transcription Factor".
This graph shows the total number of publications written about "PAX5 Transcription Factor" by people in this website by year, and whether "PAX5 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 2 | 3 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "PAX5 Transcription Factor" by people in Profiles.
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PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 02; 51(2):296-307.
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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018 04 05; 173(2):470-484.e18.
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Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer. Epigenetics. 2014 Jul; 9(7):1031-46.
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A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nat Genet. 2013 Oct; 45(10):1226-1231.
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B-cell transcription factor expression and immunoglobulin gene rearrangement frequency in acute myeloid leukemia with t(8;21)(q22;q22). Am J Clin Pathol. 2013 Sep; 140(3):355-62.
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Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny. Eur J Immunol. 2013 Nov; 43(11):3061-75.
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Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. Am J Clin Pathol. 2013 Feb; 139(2):210-9.
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Modulation of PKC-a promotes lineage reprogramming of committed B lymphocytes. Eur J Immunol. 2012 Apr; 42(4):1005-15.
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A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol. 2012 Jan 22; 13(3):300-7.
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Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung. Arch Pathol Lab Med. 2010 11; 134(11):1702-5.