PAX6 Transcription Factor
"PAX6 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A paired box transcription factor that has important functions in the development of the eye, nose, central nervous system and pancreas. Mutations in the PAX6 gene are associated with ocular disorders such as ANIRIDIA.
| Descriptor ID |
D000071841
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| MeSH Number(s) |
D12.776.260.645.813 D12.776.930.700.813
|
| Concept/Terms |
PAX6 Transcription Factor- PAX6 Transcription Factor
- Factor, PAX6 Transcription
- Transcription Factor, PAX6
- Pax-6 Protein
- Pax 6 Protein
- Protein, Pax-6
- Paired Box Gene 6 Protein
- Oculorhombin
- Paired Box Transcription Factor 6
- Transcription Factor PAX6
- Factor PAX6, Transcription
- PAX6, Transcription Factor
- Aniridia Type II Protein
- PAX6 Protein
- Protein, PAX6
- Paired Box Protein Pax-6
- Paired Box Protein Pax 6
|
Below are MeSH descriptors whose meaning is more general than "PAX6 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "PAX6 Transcription Factor".
This graph shows the total number of publications written about "PAX6 Transcription Factor" by people in this website by year, and whether "PAX6 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "PAX6 Transcription Factor" by people in Profiles.
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Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations. Neuron. 2018 12 19; 100(6):1354-1368.e5.
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The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function. Protein Cell. 2015 Jan; 6(1):68-78.
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Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. Dev Biol. 2014 Feb 01; 386(1):152-64.
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A review of the clinical and genetic aspects of aniridia. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):306-12.
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Revisiting a classic example of transcription factor functional equivalence: are Eyeless and Pax6 functionally equivalent or divergent? J Exp Zool B Mol Dev Evol. 2011 Mar 15; 316B(2):93-8.
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Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol. 2010 Sep; 30(17):4234-44.
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PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene. J Biol Chem. 2009 Oct 02; 284(40):27524-32.
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PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation. Mol Carcinog. 2008 Feb; 47(2):148-56.
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Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol. 2007 Sep 15; 309(2):285-97.
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Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex. J Neurosci. 2003 Jul 23; 23(16):6399-403.