"alpha-Synuclein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.
Descriptor ID |
D051844
|
MeSH Number(s) |
D12.776.631.860.500 D12.776.637.500
|
Concept/Terms |
alpha-Synuclein- alpha-Synuclein
- alpha Synuclein
- Non-AB Component of AD Amyloid Protein
- Non AB Component of AD Amyloid Protein
|
Below are MeSH descriptors whose meaning is more general than "alpha-Synuclein".
Below are MeSH descriptors whose meaning is more specific than "alpha-Synuclein".
This graph shows the total number of publications written about "alpha-Synuclein" by people in this website by year, and whether "alpha-Synuclein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2005 | 0 | 1 | 1 |
2007 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2015 | 1 | 1 | 2 |
2016 | 0 | 1 | 1 |
2017 | 0 | 1 | 1 |
2018 | 1 | 2 | 3 |
2022 | 0 | 1 | 1 |
2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha-Synuclein" by people in Profiles.
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Parkinson's disease-associated mutations in a-synuclein alters its lipid-bound state. Biophys J. 2024 Jun 18; 123(12):1610-1619.
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Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Mov Disord. 2022 10; 37(10):2110-2121.
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Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure. 2019 03 05; 27(3):449-463.e7.
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Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8.
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Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):E5008-E5017.
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Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features. Mov Disord. 2018 02; 33(2):282-288.
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Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep. 2017 08 21; 7(1):9008.
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Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum. Sci Rep. 2017 07 13; 7(1):5283.
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5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. J Med Chem. 2016 Apr 14; 59(7):2928-41.
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Role for the microtubule-associated protein tau variant p.A152T in risk of a-synucleinopathies. Neurology. 2015 Nov 10; 85(19):1680-6.