"Protein Deglycase DJ-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
| Descriptor ID |
D000071617
|
| MeSH Number(s) |
D08.811.277.785 D12.776.637.875
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| Concept/Terms |
Protein Deglycase DJ-1- Protein Deglycase DJ-1
- DJ-1, Protein Deglycase
- DJ-1-PARK7 Protein
- DJ 1 PARK7 Protein
- DJ-1 Protein
- DJ 1 Protein
- Parkinson Protein 7
- DJ1 Protein
- PARK7 Protein
- Parkinsonism Associated Deglycase
- Deglycase, Parkinsonism Associated
|
Below are MeSH descriptors whose meaning is more general than "Protein Deglycase DJ-1".
Below are MeSH descriptors whose meaning is more specific than "Protein Deglycase DJ-1".
This graph shows the total number of publications written about "Protein Deglycase DJ-1" by people in this website by year, and whether "Protein Deglycase DJ-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Deglycase DJ-1" by people in Profiles.
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PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function. Biochemistry. 2023 11 07; 62(21):3126-3133.
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Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1. Mol Cell Proteomics. 2012 Feb; 11(2):M111.010892.
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Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 2010 Dec 02; 468(7324):696-700.
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Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Hum Mol Genet. 2007 Dec 01; 16(23):2900-10.
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A limited role for DJ1 in Parkinson disease susceptibility. Neurology. 2004 Aug 10; 63(3):550-3.