 2',5'-Oligoadenylate Synthetase
"2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.
| Descriptor ID |
D015088
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| MeSH Number(s) |
D08.811.913.696.445.625
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| Concept/Terms |
2',5'-Oligoadenylate Synthetase- 2',5'-Oligoadenylate Synthetase
- 2',5' Oligoadenylate Synthetase
- Synthetase, 2',5'-Oligoadenylate
- 2,5 Oligoadenylate Polymerase
- Oligoadenylate Polymerase, 2,5
- Polymerase, 2,5 Oligoadenylate
- 2',5'-Oligoadenylate Polymerase
- 2',5' Oligoadenylate Polymerase
- Polymerase, 2',5'-Oligoadenylate
- (2'-5')An Polymerase
- ATP-(2'-5')oligo(A)adenylyltransferase
- 2',5'-Oligo(A) Synthetase
- 2',5'-Oligo(A) Polymerase
- 2,5 Oligoadenylate Synthetase
- Oligoadenylate Synthetase, 2,5
- Synthetase, 2,5 Oligoadenylate
- 2-5A Synthetase
- 2 5A Synthetase
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Below are MeSH descriptors whose meaning is more general than "2',5'-Oligoadenylate Synthetase".
Below are MeSH descriptors whose meaning is more specific than "2',5'-Oligoadenylate Synthetase".
This graph shows the total number of publications written about "2',5'-Oligoadenylate Synthetase" by people in this website by year, and whether "2',5'-Oligoadenylate Synthetase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "2',5'-Oligoadenylate Synthetase" by people in Profiles.
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Sams AJ, Dumaine A, Nédélec Y, Yotova V, Alfieri C, Tanner JE, Messer PW, Barreiro LB. Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans. Genome Biol. 2016 11 29; 17(1):246.
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Çaliskan M, Baker SW, Gilad Y, Ober C. Host genetic variation influences gene expression response to rhinovirus infection. PLoS Genet. 2015 Apr; 11(4):e1005111.
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Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Chayama K. IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy. J Hepatol. 2011 Jun; 54(6):1094-101.
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Sen N, Hara MR, Ahmad AS, Cascio MB, Kamiya A, Ehmsen JT, Agrawal N, Aggrawal N, Hester L, Doré S, Snyder SH, Sawa A. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 2009 Jul 16; 63(1):81-91.
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Feng X, Petraglia AL, Chen M, Byskosh PV, Boos MD, Reder AT. Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1. J Neuroimmunol. 2002 Aug; 129(1-2):205-15.
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Lam NP, Pitrak D, Speralakis R, Lau AH, Wiley TE, Layden TJ. Effect of obesity on pharmacokinetics and biologic effect of interferon-alpha in hepatitis C. Dig Dis Sci. 1997 Jan; 42(1):178-85.
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Byskosh PV, Reder AT. Interferon beta-1b effects on cytokine mRNA in peripheral mononuclear cells in multiple sclerosis. Mult Scler. 1996 Apr; 1(5):262-9.
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Desai SY, Patel RC, Sen GC, Malhotra P, Ghadge GD, Thimmapaya B. Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA. J Biol Chem. 1995 Feb 17; 270(7):3454-61.
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Saunders M, Gewert D, Castelino M, Rutherford M, Flenniken A, Willard H, Williams BR. Characterization of the small 2-5A synthetase gene in human and mouse cells. Prog Clin Biol Res. 1985; 202:163-74.
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