Nicotinamide-Nucleotide Adenylyltransferase
"Nicotinamide-Nucleotide Adenylyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.
| Descriptor ID |
D009612
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| MeSH Number(s) |
D08.811.913.696.445.600 D12.776.157.687.499 D12.776.660.720.499
|
| Concept/Terms |
Nicotinamide-Nucleotide Adenylyltransferase- Nicotinamide-Nucleotide Adenylyltransferase
- Adenylyltransferase, Nicotinamide-Nucleotide
- Nicotinamide Nucleotide Adenylyltransferase
- NMN Adenylyltransferase
- Adenylyltransferase, NMN
- Nicotinamide Mononucleotide Adenylyltransferase
- Adenylyltransferase, Nicotinamide Mononucleotide
- Mononucleotide Adenylyltransferase, Nicotinamide
- ATP-NMN Adenylyltransferase
- ATP NMN Adenylyltransferase
- Adenylyltransferase, ATP-NMN
- NAD Pyrophosphorylase
- Pyrophosphorylase, NAD
|
Below are MeSH descriptors whose meaning is more general than "Nicotinamide-Nucleotide Adenylyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Nicotinamide-Nucleotide Adenylyltransferase".
This graph shows the total number of publications written about "Nicotinamide-Nucleotide Adenylyltransferase" by people in this website by year, and whether "Nicotinamide-Nucleotide Adenylyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nicotinamide-Nucleotide Adenylyltransferase" by people in Profiles.
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NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. Elife. 2021 12 17; 10.
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Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity. Proc Natl Acad Sci U S A. 2019 09 17; 116(38):19165-19175.
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Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress. Nat Commun. 2015 Nov 30; 6:10057.
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Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot. EMBO Rep. 2013 Jan; 14(1):87-94.
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NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum Mol Genet. 2012 Jan 15; 21(2):237-50.