"Caspase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
| Descriptor ID |
D053143
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.550.200 D08.811.277.656.300.200.126.550.200 D12.644.360.075.405.550.200 D12.776.476.075.405.550.200
|
| Concept/Terms |
Caspase 2- Caspase 2
- ICH-1 Protease
- ICH 1 Protease
- Caspase-2
Procaspase-2- Procaspase-2
- Procaspase 2
- Pro-Caspase-2
- Pro Caspase 2
|
Below are MeSH descriptors whose meaning is more general than "Caspase 2".
Below are MeSH descriptors whose meaning is more specific than "Caspase 2".
This graph shows the total number of publications written about "Caspase 2" by people in this website by year, and whether "Caspase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspase 2" by people in Profiles.
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Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet. 2016 Nov 03; 99(5):1117-1129.
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IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22.
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Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun; 28(12):3943-51.
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An intronic signal for alternative splicing in the human genome. PLoS One. 2007 Nov 28; 2(11):e1246.
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Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors. J Immunol. 2005 Oct 01; 175(7):4518-27.
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Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm. FASEB J. 2005 Nov; 19(13):1848-50.
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Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2280-6.
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Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases. J Biol Chem. 2003 May 09; 278(19):16466-9.
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Ischemic preconditioning attenuates apoptotic cell death in the rat retina. Invest Ophthalmol Vis Sci. 2002 Sep; 43(9):3059-66.