"Caspases, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
| Descriptor ID |
D053471
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| MeSH Number(s) |
D08.811.277.656.262.500.126.550 D08.811.277.656.300.200.126.550 D12.644.360.075.405.550 D12.776.476.075.405.550
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspases, Initiator".
Below are MeSH descriptors whose meaning is more specific than "Caspases, Initiator".
This graph shows the total number of publications written about "Caspases, Initiator" by people in this website by year, and whether "Caspases, Initiator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspases, Initiator" by people in Profiles.
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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-ß deposition in Alzheimer's disease. Alzheimers Res Ther. 2024 02 08; 16(1):29.