MAP Kinase Signaling System
"MAP Kinase Signaling System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Descriptor ID |
D020935
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MeSH Number(s) |
G02.111.087.800.560 G02.149.115.800.560 G03.495.553.560 G04.299.880.560
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Concept/Terms |
ERK1-2 Pathway- ERK1-2 Pathway
- ERK1 2 Pathway
- ERK1-2 Pathways
- Pathway, ERK1-2
- Pathways, ERK1-2
- ERK1 and ERK2 Pathway
p38 Kinase Pathway- p38 Kinase Pathway
- Kinase Pathway, p38
- Kinase Pathways, p38
- Pathway, p38 Kinase
- Pathways, p38 Kinase
- p38 Kinase Pathways
- p38 Kinase Signaling Pathway
MAP Kinase Cascade- MAP Kinase Cascade
- Cascade, MAP Kinase
- Kinase Cascade, MAP
- MAP Kinase Cascades
- MAP Kinase Signaling Cascades
- MAP Kinase Modules
- MAP Kinase Module
- Module, MAP Kinase
MEK-ERK Pathway- MEK-ERK Pathway
- MEK ERK Pathway
- MEK-ERK Pathways
- Pathway, MEK-ERK
- Pathways, MEK-ERK
JNK Pathway- JNK Pathway
- JNK Pathways
- Pathway, JNK
- Pathways, JNK
- JNK Signaling Pathway
- JNK Signaling Pathways
- Pathway, JNK Signaling
- Pathways, JNK Signaling
- Signaling Pathway, JNK
- Signaling Pathways, JNK
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Signaling System".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Signaling System".
This graph shows the total number of publications written about "MAP Kinase Signaling System" by people in this website by year, and whether "MAP Kinase Signaling System" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 | 2000 | 3 | 1 | 4 | 2001 | 5 | 4 | 9 | 2002 | 7 | 4 | 11 | 2003 | 4 | 0 | 4 | 2004 | 2 | 4 | 6 | 2005 | 1 | 9 | 10 | 2006 | 3 | 4 | 7 | 2007 | 2 | 2 | 4 | 2008 | 2 | 5 | 7 | 2009 | 0 | 6 | 6 | 2010 | 1 | 9 | 10 | 2011 | 3 | 7 | 10 | 2012 | 3 | 5 | 8 | 2013 | 7 | 6 | 13 | 2014 | 3 | 8 | 11 | 2015 | 2 | 4 | 6 | 2016 | 2 | 1 | 3 | 2017 | 2 | 3 | 5 | 2018 | 1 | 1 | 2 | 2019 | 0 | 1 | 1 | 2020 | 1 | 3 | 4 | 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "MAP Kinase Signaling System" by people in Profiles.
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Yesilkanal AE, Yang D, Valdespino A, Tiwari P, Sabino AU, Nguyen LC, Lee J, Xie XH, Sun S, Dann C, Robinson-Mailman L, Steinberg E, Stuhlmiller T, Frankenberger C, Goldsmith E, Johnson GL, Ramos AF, Rosner MR. Limited inhibition of multiple nodes in a driver network blocks metastasis. Elife. 2021 05 11; 10.
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Zhang Q, Zheng M, Betancourt CE, Liu L, Sitikov A, Sladojevic N, Zhao Q, Zhang JH, Liao JK, Wu R. Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway. Oxid Med Cell Longev. 2021; 2021:6655122.
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Wu C, Boisclair Lachance JF, Ludwig MZ, Rebay I. A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition. PLoS Genet. 2020 11; 16(11):e1009216.
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Medina MV, D Agostino A, Ma Q, Eroles P, Cavallin L, Chiozzini C, Sapochnik D, Cymeryng C, Hyjek E, Cesarman E, Naipauer J, Mesri EA, Coso OA. KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma. PLoS Pathog. 2020 10; 16(10):e1009006.
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Sheng Z, Du W. NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways. PLoS Genet. 2020 06; 16(6):e1008863.
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Kang T, Boland BB, Jensen P, Alarcon C, Nawrocki A, Grimsby JS, Rhodes CJ, Larsen MR. Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice. Mol Cell Proteomics. 2020 06; 19(6):971-993.
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Aggarwal M, Leser GP, Lamb RA. Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses. J Virol. 2020 02 28; 94(6).
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Chapman EM, Lant B, Ohashi Y, Yu B, Schertzberg M, Go C, Dogra D, Koskimäki J, Girard R, Li Y, Fraser AG, Awad IA, Abdelilah-Seyfried S, Gingras AC, Derry WB. A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nat Commun. 2019 04 17; 10(1):1791.
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Zwang NA, Ganesh BB, Cardenas KT, Chong AS, Finn PW, Perkins DL. An optimized protocol to quantify signaling in human transitional B cells by phospho flow cytometry. J Immunol Methods. 2018 12; 463:112-121.
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Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Nebreda AR, Lengyel E. Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metab. 2019 01 08; 29(1):141-155.e9.
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