 Hepatocyte Nuclear Factor 1-beta
"Hepatocyte Nuclear Factor 1-beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hepatocyte nuclear factor that is closely related to HEPATOCYTE NUCLEAR FACTOR 1-ALPHA but is only weakly expressed in the LIVER. Mutations in hepatocyte nuclear factor 1-beta are associated with renal CYSTS and MATURITY-ONSET DIABETES MELLITUS type 5.
| Descriptor ID |
D051539
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| MeSH Number(s) |
D12.776.260.262.500.750 D12.776.660.352.500.750 D12.776.930.323.500.750
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| Concept/Terms |
Hepatocyte Nuclear Factor 1-beta- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 1 beta
- Variant Hepatic Nuclear Factor 1
- Liver Specific Transcription Factor LF-B3
- Liver Specific Transcription Factor LF B3
- Hepatocyte Nuclear Factor-1beta
- Hepatocyte Nuclear Factor 1beta
- HNF-1beta
- HNF 1beta
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Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 1-beta".
Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 1-beta".
This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 1-beta" by people in this website by year, and whether "Hepatocyte Nuclear Factor 1-beta" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 6 | 6 | | 1998 | 0 | 2 | 2 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hepatocyte Nuclear Factor 1-beta" by people in Profiles.
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Billings LK, Jablonski KA, Warner AS, Cheng YC, McAteer JB, Tipton L, Shuldiner AR, Ehrmann DA, Manning AK, Dabelea D, Franks PW, Kahn SE, Pollin TI, Knowler WC, Altshuler D, Florez JC. Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention. J Clin Endocrinol Metab. 2017 08 01; 102(8):2678-2689.
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Kim L, Liao J, Zhang M, Talamonti M, Bentrem D, Rao S, Yang GY. Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1beta. Mod Pathol. 2008 Sep; 21(9):1075-83.
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Hara M, Shen J, Pugh W, Polonsky KS, Le Beau MM, Bell GI. Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis. Exp Clin Endocrinol Diabetes. 2007 Nov; 115(10):654-61.
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Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors. Science. 2004 Feb 27; 303(5662):1378-81.
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So WY, Ng MC, Horikawa Y, Nj?lstad PR, Li JK, Ma RC, Bell GI, Chan JC. Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy. J Diabetes Complications. 2003 Nov-Dec; 17(6):369-73.
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Shih DQ, Screenan S, Munoz KN, Philipson L, Pontoglio M, Yaniv M, Polonsky KS, Stoffel M. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes. 2001 Nov; 50(11):2472-80.
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Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes. 2001 May; 50(5):928-36.
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Ng MC, Li JK, So WY, Critchley JA, Cockram CS, Bell GI, Chan JC. Nature or nurture: an insightful illustration from a Chinese family with hepatocyte nuclear factor-1 alpha diabetes (MODY3) Diabetologia. 2000 Jun; 43(6):816-8.
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Bj?rkhaug L, S?vik O, Bell GI, Nj?lstad PR, Molven A. A simple test for the high-frequency P291fsinsC mutation in the HNF1 alpha/MODY3 gene. Diabetologia. 2000 Jun; 43(6):818-9.
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Bingham C, Ellard S, Allen L, Bulman M, Shepherd M, Frayling T, Berry PJ, Clark PM, Lindner T, Bell GI, Ryffel GU, Nicholls AJ, Hattersley AT. Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. Kidney Int. 2000 Mar; 57(3):898-907.
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