"Protein Kinase C-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
| Descriptor ID |
D051571
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.100
|
| Concept/Terms |
Protein Kinase C-alpha- Protein Kinase C-alpha
- Protein Kinase C(alpha)
- PKC-alpha Serine-Threonine Kinase
- PKC alpha Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-alpha
- Protein Kinase C alpha
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-alpha".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-alpha".
This graph shows the total number of publications written about "Protein Kinase C-alpha" by people in this website by year, and whether "Protein Kinase C-alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Protein Kinase C-alpha" by people in Profiles.
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All-trans retinoic acid and protein kinase C a/ß1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression. Sci Rep. 2021 03 15; 11(1):6044.
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Activating p53 function by targeting RLIP. Biochim Biophys Acta Rev Cancer. 2021 04; 1875(2):188512.
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Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCa subversion induces up-regulation of PKCßII expression in B lymphocytes. Haematologica. 2015 Apr; 100(4):499-510.
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Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension. 2013 Aug; 62(2):391-7.
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Lipopolysaccharide-induced phosphorylation of c-Met tyrosine residue 1003 regulates c-Met intracellular trafficking and lung epithelial barrier function. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 01; 305(1):L56-63.
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The kinase PKCa selectively upregulates interleukin-17A during Th17 cell immune responses. Immunity. 2013 Jan 24; 38(1):41-52.
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Modulation of PKC-a promotes lineage reprogramming of committed B lymphocytes. Eur J Immunol. 2012 Apr; 42(4):1005-15.
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Conventional protein kinase C-a (PKC-a) and PKC-ß negatively regulate RIG-I antiviral signal transduction. J Virol. 2012 Feb; 86(3):1358-71.
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G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C. J Biol Chem. 2010 Apr 30; 285(18):13748-60.
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Activation of protein kinase C{eta} by type I interferons. J Biol Chem. 2009 Apr 17; 284(16):10301-14.