 G Protein-Coupled Inwardly-Rectifying Potassium Channels
"G Protein-Coupled Inwardly-Rectifying Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of inwardly-rectifying potassium channels that are activated by PERTUSSIS TOXIN sensitive G-PROTEIN-COUPLED RECEPTORS. GIRK potassium channels are primarily activated by the complex of GTP-BINDING PROTEIN BETA SUBUNITS and GTP-BINDING PROTEIN GAMMA SUBUNITS.
| Descriptor ID |
D051676
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| MeSH Number(s) |
D12.776.157.530.400.600.450.500 D12.776.543.550.425.750.450.500 D12.776.543.585.400.750.450.500
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| Concept/Terms |
G Protein-Coupled Inwardly-Rectifying Potassium Channels- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- G Protein Coupled Inwardly Rectifying Potassium Channels
- GIRK Potassium Channels
- Potassium Channels, GIRK
- Kir3 Potassium Channels
- Potassium Channels, Kir3
- G Protein-Activated Potassium Channels
- G Protein Activated Potassium Channels
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Below are MeSH descriptors whose meaning is more general than "G Protein-Coupled Inwardly-Rectifying Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "G Protein-Coupled Inwardly-Rectifying Potassium Channels".
This graph shows the total number of publications written about "G Protein-Coupled Inwardly-Rectifying Potassium Channels" by people in this website by year, and whether "G Protein-Coupled Inwardly-Rectifying Potassium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "G Protein-Coupled Inwardly-Rectifying Potassium Channels" by people in Profiles.
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Markou A, Sertedaki A, Kaltsas G, Androulakis II, Marakaki C, Pappa T, Gouli A, Papanastasiou L, Fountoulakis S, Zacharoulis A, Karavidas A, Ragkou D, Charmandari E, Chrousos GP, Piaditis GP. Stress-induced Aldosterone Hyper-Secretion in a Substantial Subset of Patients With Essential Hypertension. J Clin Endocrinol Metab. 2015 Aug; 100(8):2857-64.
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Kokunai Y, Nakata T, Furuta M, Sakata S, Kimura H, Aiba T, Yoshinaga M, Osaki Y, Nakamori M, Itoh H, Sato T, Kubota T, Kadota K, Shindo K, Mochizuki H, Shimizu W, Horie M, Okamura Y, Ohno K, Takahashi MP. A Kir3.4 mutation causes Andersen-Tawil syndrome by an inhibitory effect on Kir2.1. Neurology. 2014 Mar 25; 82(12):1058-64.
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McGehee DS. GIRK channels as a target for SSRIs. Focus on "reduced 5-HT1A- and GABAB receptor function in dorsal raphe neurons upon chronic fluoxetine treatment of socially stressed rats". J Neurophysiol. 2007 Jul; 98(1):1-2.
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Haider S, Grottesi A, Hall BA, Ashcroft FM, Sansom MS. Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating. Biophys J. 2005 May; 88(5):3310-20.
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Sarac R, Hou P, Hurley KM, Hriciste D, Cohen NA, Nelson DJ. Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function. J Neurosci. 2005 Feb 16; 25(7):1836-46.
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Harkins AB, Fox AP. Cell death in weaver mouse cerebellum. Cerebellum. 2002 Jul; 1(3):201-6.
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Harkins AB, Dlouhy S, Ghetti B, Cahill AL, Won L, Heller B, Heller A, Fox AP. Evidence of elevated intracellular calcium levels in weaver homozygote mice. J Physiol. 2000 Apr 15; 524 Pt 2:447-55.
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Hou P, Yan S, Tang W, Nelson DJ. The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype. J Neurosci. 1999 Oct 01; 19(19):8327-36.
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Fox AP, Dlouhy S, Ghetti B, Hurley JH, Nucifora PG, Nelson DJ, Won L, Heller A. Altered responses to potassium in cerebellar neurons from weaver heterozygote mice. Exp Brain Res. 1998 Dec; 123(3):298-306.
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Philipson LH, Kuznetsov A, Toth PT, Murphy JF, Szabo G, Ma GH, Miller RJ. Functional expression of an epitope-tagged G protein-coupled K+ channel (GIRK1). J Biol Chem. 1995 Jun 16; 270(24):14604-10.
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