G Protein-Coupled Inwardly-Rectifying Potassium Channels
"G Protein-Coupled Inwardly-Rectifying Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of inwardly-rectifying potassium channels that are activated by PERTUSSIS TOXIN sensitive G-PROTEIN-COUPLED RECEPTORS. GIRK potassium channels are primarily activated by the complex of GTP-BINDING PROTEIN BETA SUBUNITS and GTP-BINDING PROTEIN GAMMA SUBUNITS.
Descriptor ID |
D051676
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MeSH Number(s) |
D12.776.157.530.400.600.450.500 D12.776.543.550.450.750.450.500 D12.776.543.585.400.750.450.500
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Concept/Terms |
G Protein-Coupled Inwardly-Rectifying Potassium Channels- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- G Protein Coupled Inwardly Rectifying Potassium Channels
- GIRK Potassium Channels
- Potassium Channels, GIRK
- G Protein-Activated Potassium Channels
- G Protein Activated Potassium Channels
- Kir3 Potassium Channels
- Potassium Channels, Kir3
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Below are MeSH descriptors whose meaning is more general than "G Protein-Coupled Inwardly-Rectifying Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "G Protein-Coupled Inwardly-Rectifying Potassium Channels".
This graph shows the total number of publications written about "G Protein-Coupled Inwardly-Rectifying Potassium Channels" by people in this website by year, and whether "G Protein-Coupled Inwardly-Rectifying Potassium Channels" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
1999 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2002 | 0 | 1 | 1 |
2005 | 0 | 2 | 2 |
2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "G Protein-Coupled Inwardly-Rectifying Potassium Channels" by people in Profiles.
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Stress-induced Aldosterone Hyper-Secretion in a Substantial Subset of Patients With Essential Hypertension. J Clin Endocrinol Metab. 2015 Aug; 100(8):2857-64.
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A Kir3.4 mutation causes Andersen-Tawil syndrome by an inhibitory effect on Kir2.1. Neurology. 2014 Mar 25; 82(12):1058-64.
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GIRK channels as a target for SSRIs. Focus on "reduced 5-HT1A- and GABAB receptor function in dorsal raphe neurons upon chronic fluoxetine treatment of socially stressed rats". J Neurophysiol. 2007 Jul; 98(1):1-2.
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Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating. Biophys J. 2005 May; 88(5):3310-20.
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Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function. J Neurosci. 2005 Feb 16; 25(7):1836-46.
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Cell death in weaver mouse cerebellum. Cerebellum. 2002 Jul; 1(3):201-6.
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Evidence of elevated intracellular calcium levels in weaver homozygote mice. J Physiol. 2000 Apr 15; 524 Pt 2:447-55.
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The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype. J Neurosci. 1999 Oct 01; 19(19):8327-36.
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Altered responses to potassium in cerebellar neurons from weaver heterozygote mice. Exp Brain Res. 1998 Dec; 123(3):298-306.
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Functional expression of an epitope-tagged G protein-coupled K+ channel (GIRK1). J Biol Chem. 1995 Jun 16; 270(24):14604-10.