 Amyloid Precursor Protein Secretases
"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.
| Descriptor ID |
D053829
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| MeSH Number(s) |
D08.811.277.656.300.032
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".
Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".
This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 4 | 4 | | 2002 | 0 | 5 | 5 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 4 | 4 | | 2005 | 0 | 5 | 5 | | 2006 | 0 | 4 | 4 | | 2007 | 2 | 2 | 4 | | 2008 | 4 | 2 | 6 | | 2009 | 1 | 0 | 1 | | 2010 | 4 | 2 | 6 | | 2011 | 5 | 0 | 5 | | 2012 | 3 | 2 | 5 | | 2013 | 4 | 1 | 5 | | 2014 | 6 | 2 | 8 | | 2015 | 3 | 2 | 5 | | 2016 | 3 | 0 | 3 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.
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Roos K, Wu C, Damm W, Reboul M, Stevenson JM, Lu C, Dahlgren MK, Mondal S, Chen W, Wang L, Abel R, Friesner RA, Harder ED. OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules. J Chem Theory Comput. 2019 Mar 12; 15(3):1863-1874.
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Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, Andrew RJ, Thinakaran G, Posse de Chaves E, Kar S. Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells. Mol Cell Biol. 2018 06 01; 38(11).
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Sun R, He T, Pan Y, Katusic ZS. Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. Aging (Albany NY). 2018 01 15; 10(1):100-114.
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Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9665-E9674.
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Andrew RJ, Kellett KA, Thinakaran G, Hooper NM. A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis. J Biol Chem. 2016 09 09; 291(37):19235-44.
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Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aß generation in Alzheimer's disease. Acta Neuropathol. 2016 08; 132(2):235-256.
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Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating ?-Secretase Activity. J Biol Chem. 2016 Mar 25; 291(13):6748-53.
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Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME. Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Sci Rep. 2015 Nov 26; 5:17042.
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Zhang X, Yu CJ, Sisodia SS. The topology of pen-2, a ?-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain. Mol Neurodegener. 2015 Aug 22; 10:39.
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Buggia-Prévot V, Thinakaran G. Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons. Bioessays. 2015 Aug; 37(8):888-98.
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