Amyloid Precursor Protein Secretases
"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.
| Descriptor ID |
D053829
|
| MeSH Number(s) |
D08.811.277.656.300.032
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".
Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".
This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 5 | 5 |
| 2006 | 0 | 4 | 4 |
| 2007 | 2 | 2 | 4 |
| 2008 | 4 | 1 | 5 |
| 2009 | 1 | 0 | 1 |
| 2010 | 3 | 2 | 5 |
| 2011 | 5 | 0 | 5 |
| 2012 | 3 | 2 | 5 |
| 2013 | 3 | 0 | 3 |
| 2014 | 6 | 1 | 7 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.
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RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta-site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain. J Labelled Comp Radiopharm. 2023 07; 66(9):222-236.
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Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa. HGG Adv. 2023 04 13; 4(2):100187.
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AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. Cell Death Dis. 2022 08 05; 13(8):678.
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Nanoscale organization of Nicastrin, the substrate receptor of the ?-secretase complex, as independent molecular domains. Mol Brain. 2021 10 13; 14(1):158.
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Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium. Nat Genet. 2020 06; 52(6):604-614.
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Negative evidence for a role of APH1B T27I variant in Alzheimer's disease. Hum Mol Genet. 2020 04 15; 29(6):955-966.
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OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules. J Chem Theory Comput. 2019 Mar 12; 15(3):1863-1874.
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Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem. 2019 03 22; 294(12):4477-4487.
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Staphylococcus aureus alpha toxin activates Notch in vascular cells. Angiogenesis. 2019 02; 22(1):197-209.
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Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells. Mol Cell Biol. 2018 06 01; 38(11).