"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
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| MeSH Number(s) |
A08.637.400 A11.650.400
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 2 | 1 | 3 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 4 | 1 | 5 |
| 2009 | 2 | 2 | 4 |
| 2010 | 2 | 3 | 5 |
| 2011 | 3 | 2 | 5 |
| 2012 | 2 | 6 | 8 |
| 2013 | 2 | 1 | 3 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 4 | 3 | 7 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 2 | 4 |
| 2020 | 1 | 2 | 3 |
| 2021 | 1 | 4 | 5 |
| 2022 | 2 | 1 | 3 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 6 | 7 |
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Below are the most recent publications written about "Microglia" by people in Profiles.
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Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer's disease. Neurotherapeutics. 2024 Oct; 21(6):e00426.
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Sex differences in mechanisms of pain hypersensitivity. Neurosci Biobehav Rev. 2024 Aug; 163:105749.
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Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease. Brain Behav Immun. 2024 Jul; 119:919-944.
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Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits. Brain Behav Immun. 2024 Jul; 119:333-350.
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Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Feb 17; 19(1):18.
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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-ß deposition in Alzheimer's disease. Alzheimers Res Ther. 2024 02 08; 16(1):29.
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Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function. Sci Rep. 2024 01 21; 14(1):1827.
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Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome. Mol Neurodegener. 2023 Dec 16; 18(1):95.
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The gut microbiome regulates astrocyte reaction to Aß amyloidosis through microglial dependent and independent mechanisms. Mol Neurodegener. 2023 Jul 06; 18(1):45.
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BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. Mol Neurodegener. 2022 05 07; 17(1):33.